Effects of primaquine and chloroquine on oxidative stress parameters in rats
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Outros Autores: | , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Anais da Academia Brasileira de Ciências (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652015000301487 |
Resumo: | Primaquine and chloroquine are used for the treatment of malaria; evidence from the literature suggests that these drugs may induce oxidative stress. In this study we investigated the effects of primaquine and chloroquine on oxidative damage and DNA damage in brain, liver and kidney of rats after 7, 14 and 21 days of administration. Our results demonstrated that primaquine causes DNA damage in brain after 7, 14 and 21 days, and in liver after 7 and 14 days. Moreover, primaquine increases TBARS levels in the kidney and protein carbonyls in the brain after 14 days, and decreases protein carbonyls in the liver after 7 days. Whereas chloroquine causes DNA damage in the kidney after 7 and 14 days, and in the liver after 14 and 21 days, increases TBARS levels in the kidney after 7 days, and decreases TBARS levels in the brain after 21 days. Moreover, decreases protein carbonyls in the liver after 7 and 14 days, and in the brain after 7 and 21 days. However, chloroquine treatment for 14 days increases protein carbonyls in the brain and kidney. In conclusion, these results showed that prolonged treatment with antimalarial may adversely affect the DNA. |
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Effects of primaquine and chloroquine on oxidative stress parameters in ratsprimaquinechloroquineoxidative damageDNA damageantimalarial drugsPrimaquine and chloroquine are used for the treatment of malaria; evidence from the literature suggests that these drugs may induce oxidative stress. In this study we investigated the effects of primaquine and chloroquine on oxidative damage and DNA damage in brain, liver and kidney of rats after 7, 14 and 21 days of administration. Our results demonstrated that primaquine causes DNA damage in brain after 7, 14 and 21 days, and in liver after 7 and 14 days. Moreover, primaquine increases TBARS levels in the kidney and protein carbonyls in the brain after 14 days, and decreases protein carbonyls in the liver after 7 days. Whereas chloroquine causes DNA damage in the kidney after 7 and 14 days, and in the liver after 14 and 21 days, increases TBARS levels in the kidney after 7 days, and decreases TBARS levels in the brain after 21 days. Moreover, decreases protein carbonyls in the liver after 7 and 14 days, and in the brain after 7 and 21 days. However, chloroquine treatment for 14 days increases protein carbonyls in the brain and kidney. In conclusion, these results showed that prolonged treatment with antimalarial may adversely affect the DNA.Academia Brasileira de Ciências2015-08-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652015000301487Anais da Academia Brasileira de Ciências v.87 n.2 suppl.0 2015reponame:Anais da Academia Brasileira de Ciências (Online)instname:Academia Brasileira de Ciências (ABC)instacron:ABC10.1590/0001-3765201520140637info:eu-repo/semantics/openAccessGIOVANELLA,FRANCIANNEFERREIRA,GABRIELA K.PRÁ,SAMIRA D.T. DECARVALHO-SILVA,MILENAGOMES,LARA M.SCAINI,GISELLIGONÇALVES,RENATA C.MICHELS,MONIQUEGALANT,LETÍCIA S.LONGARETTI,LUIZA M.DAJORI,ANA LUIZAANDRADE,VANESSA M.DAL-PIZZOL,FELIPESTRECK,EMILIO L.SOUZA,RENAN P. DEeng2015-09-17T00:00:00Zoai:scielo:S0001-37652015000301487Revistahttp://www.scielo.br/aabchttps://old.scielo.br/oai/scielo-oai.php||aabc@abc.org.br1678-26900001-3765opendoar:2015-09-17T00:00Anais da Academia Brasileira de Ciências (Online) - Academia Brasileira de Ciências (ABC)false |
dc.title.none.fl_str_mv |
Effects of primaquine and chloroquine on oxidative stress parameters in rats |
title |
Effects of primaquine and chloroquine on oxidative stress parameters in rats |
spellingShingle |
Effects of primaquine and chloroquine on oxidative stress parameters in rats GIOVANELLA,FRANCIANNE primaquine chloroquine oxidative damage DNA damage antimalarial drugs |
title_short |
Effects of primaquine and chloroquine on oxidative stress parameters in rats |
title_full |
Effects of primaquine and chloroquine on oxidative stress parameters in rats |
title_fullStr |
Effects of primaquine and chloroquine on oxidative stress parameters in rats |
title_full_unstemmed |
Effects of primaquine and chloroquine on oxidative stress parameters in rats |
title_sort |
Effects of primaquine and chloroquine on oxidative stress parameters in rats |
author |
GIOVANELLA,FRANCIANNE |
author_facet |
GIOVANELLA,FRANCIANNE FERREIRA,GABRIELA K. PRÁ,SAMIRA D.T. DE CARVALHO-SILVA,MILENA GOMES,LARA M. SCAINI,GISELLI GONÇALVES,RENATA C. MICHELS,MONIQUE GALANT,LETÍCIA S. LONGARETTI,LUIZA M. DAJORI,ANA LUIZA ANDRADE,VANESSA M. DAL-PIZZOL,FELIPE STRECK,EMILIO L. SOUZA,RENAN P. DE |
author_role |
author |
author2 |
FERREIRA,GABRIELA K. PRÁ,SAMIRA D.T. DE CARVALHO-SILVA,MILENA GOMES,LARA M. SCAINI,GISELLI GONÇALVES,RENATA C. MICHELS,MONIQUE GALANT,LETÍCIA S. LONGARETTI,LUIZA M. DAJORI,ANA LUIZA ANDRADE,VANESSA M. DAL-PIZZOL,FELIPE STRECK,EMILIO L. SOUZA,RENAN P. DE |
author2_role |
author author author author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
GIOVANELLA,FRANCIANNE FERREIRA,GABRIELA K. PRÁ,SAMIRA D.T. DE CARVALHO-SILVA,MILENA GOMES,LARA M. SCAINI,GISELLI GONÇALVES,RENATA C. MICHELS,MONIQUE GALANT,LETÍCIA S. LONGARETTI,LUIZA M. DAJORI,ANA LUIZA ANDRADE,VANESSA M. DAL-PIZZOL,FELIPE STRECK,EMILIO L. SOUZA,RENAN P. DE |
dc.subject.por.fl_str_mv |
primaquine chloroquine oxidative damage DNA damage antimalarial drugs |
topic |
primaquine chloroquine oxidative damage DNA damage antimalarial drugs |
description |
Primaquine and chloroquine are used for the treatment of malaria; evidence from the literature suggests that these drugs may induce oxidative stress. In this study we investigated the effects of primaquine and chloroquine on oxidative damage and DNA damage in brain, liver and kidney of rats after 7, 14 and 21 days of administration. Our results demonstrated that primaquine causes DNA damage in brain after 7, 14 and 21 days, and in liver after 7 and 14 days. Moreover, primaquine increases TBARS levels in the kidney and protein carbonyls in the brain after 14 days, and decreases protein carbonyls in the liver after 7 days. Whereas chloroquine causes DNA damage in the kidney after 7 and 14 days, and in the liver after 14 and 21 days, increases TBARS levels in the kidney after 7 days, and decreases TBARS levels in the brain after 21 days. Moreover, decreases protein carbonyls in the liver after 7 and 14 days, and in the brain after 7 and 21 days. However, chloroquine treatment for 14 days increases protein carbonyls in the brain and kidney. In conclusion, these results showed that prolonged treatment with antimalarial may adversely affect the DNA. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015-08-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652015000301487 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652015000301487 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/0001-3765201520140637 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Academia Brasileira de Ciências |
publisher.none.fl_str_mv |
Academia Brasileira de Ciências |
dc.source.none.fl_str_mv |
Anais da Academia Brasileira de Ciências v.87 n.2 suppl.0 2015 reponame:Anais da Academia Brasileira de Ciências (Online) instname:Academia Brasileira de Ciências (ABC) instacron:ABC |
instname_str |
Academia Brasileira de Ciências (ABC) |
instacron_str |
ABC |
institution |
ABC |
reponame_str |
Anais da Academia Brasileira de Ciências (Online) |
collection |
Anais da Academia Brasileira de Ciências (Online) |
repository.name.fl_str_mv |
Anais da Academia Brasileira de Ciências (Online) - Academia Brasileira de Ciências (ABC) |
repository.mail.fl_str_mv |
||aabc@abc.org.br |
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1754302861627359232 |