Antioxidant effect of simvastatin throught oxidative imbalance caused by lisdexamfetamine dimesylate
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Anais da Academia Brasileira de Ciências (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652016000100335 |
Resumo: | The present study aims to directly investigate the behavioral and antioxidant effects of simvastatin in a model of bipolar mania induced by lisdexamfetamine dimesylate. Wistar rats were treated for 30 days with simvastatin. On the 24th day after the start of treatment, each rat was administered lisdexamfetamine dimesylate for 7 days. The results suggest that simvastatin combined with lisdexamfetamine dimesylate induced a significant increased locomotion and lisdexamfetamine dimesylate administration causes an oxidative imbalance determined by an increment in lipid peroxidation, protein oxidation and alterations in the activities of antioxidant enzymes in brain areas; moreover, in the presence of simvastatin, most of these effects were prevented. These findings contribute to a better understanding of the critical roles of lisdexamfetamine dimesylate in the treatment of neuropsychiatric disorders, associated with increased oxidative stress and changes in antioxidant enzymatic defense. In view of the central role played by lisdexamfetamine dimesylate, the established antioxidant effect of simvastatin therapy is of major interest. |
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Anais da Academia Brasileira de Ciências (Online) |
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Antioxidant effect of simvastatin throught oxidative imbalance caused by lisdexamfetamine dimesylateAmphetamineLisdexamfetamine dimesylateOxidative stressSimvastatinThe present study aims to directly investigate the behavioral and antioxidant effects of simvastatin in a model of bipolar mania induced by lisdexamfetamine dimesylate. Wistar rats were treated for 30 days with simvastatin. On the 24th day after the start of treatment, each rat was administered lisdexamfetamine dimesylate for 7 days. The results suggest that simvastatin combined with lisdexamfetamine dimesylate induced a significant increased locomotion and lisdexamfetamine dimesylate administration causes an oxidative imbalance determined by an increment in lipid peroxidation, protein oxidation and alterations in the activities of antioxidant enzymes in brain areas; moreover, in the presence of simvastatin, most of these effects were prevented. These findings contribute to a better understanding of the critical roles of lisdexamfetamine dimesylate in the treatment of neuropsychiatric disorders, associated with increased oxidative stress and changes in antioxidant enzymatic defense. In view of the central role played by lisdexamfetamine dimesylate, the established antioxidant effect of simvastatin therapy is of major interest.Academia Brasileira de Ciências2016-03-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652016000100335Anais da Academia Brasileira de Ciências v.88 n.1 2016reponame:Anais da Academia Brasileira de Ciências (Online)instname:Academia Brasileira de Ciências (ABC)instacron:ABC10.1590/0001-3765201620140490info:eu-repo/semantics/openAccessEger,Guilherme A.Ferreira,Vinícius V.Batista,Camila R.Bonde,HenriqueLima,Daniela D. deWyse,Angela T.S.Cruz,Júlia N. daRodrigues,André F.Magro,Débora D. DalCruz,José G.P. daeng2016-03-07T00:00:00Zoai:scielo:S0001-37652016000100335Revistahttp://www.scielo.br/aabchttps://old.scielo.br/oai/scielo-oai.php||aabc@abc.org.br1678-26900001-3765opendoar:2016-03-07T00:00Anais da Academia Brasileira de Ciências (Online) - Academia Brasileira de Ciências (ABC)false |
dc.title.none.fl_str_mv |
Antioxidant effect of simvastatin throught oxidative imbalance caused by lisdexamfetamine dimesylate |
title |
Antioxidant effect of simvastatin throught oxidative imbalance caused by lisdexamfetamine dimesylate |
spellingShingle |
Antioxidant effect of simvastatin throught oxidative imbalance caused by lisdexamfetamine dimesylate Eger,Guilherme A. Amphetamine Lisdexamfetamine dimesylate Oxidative stress Simvastatin |
title_short |
Antioxidant effect of simvastatin throught oxidative imbalance caused by lisdexamfetamine dimesylate |
title_full |
Antioxidant effect of simvastatin throught oxidative imbalance caused by lisdexamfetamine dimesylate |
title_fullStr |
Antioxidant effect of simvastatin throught oxidative imbalance caused by lisdexamfetamine dimesylate |
title_full_unstemmed |
Antioxidant effect of simvastatin throught oxidative imbalance caused by lisdexamfetamine dimesylate |
title_sort |
Antioxidant effect of simvastatin throught oxidative imbalance caused by lisdexamfetamine dimesylate |
author |
Eger,Guilherme A. |
author_facet |
Eger,Guilherme A. Ferreira,Vinícius V. Batista,Camila R. Bonde,Henrique Lima,Daniela D. de Wyse,Angela T.S. Cruz,Júlia N. da Rodrigues,André F. Magro,Débora D. Dal Cruz,José G.P. da |
author_role |
author |
author2 |
Ferreira,Vinícius V. Batista,Camila R. Bonde,Henrique Lima,Daniela D. de Wyse,Angela T.S. Cruz,Júlia N. da Rodrigues,André F. Magro,Débora D. Dal Cruz,José G.P. da |
author2_role |
author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Eger,Guilherme A. Ferreira,Vinícius V. Batista,Camila R. Bonde,Henrique Lima,Daniela D. de Wyse,Angela T.S. Cruz,Júlia N. da Rodrigues,André F. Magro,Débora D. Dal Cruz,José G.P. da |
dc.subject.por.fl_str_mv |
Amphetamine Lisdexamfetamine dimesylate Oxidative stress Simvastatin |
topic |
Amphetamine Lisdexamfetamine dimesylate Oxidative stress Simvastatin |
description |
The present study aims to directly investigate the behavioral and antioxidant effects of simvastatin in a model of bipolar mania induced by lisdexamfetamine dimesylate. Wistar rats were treated for 30 days with simvastatin. On the 24th day after the start of treatment, each rat was administered lisdexamfetamine dimesylate for 7 days. The results suggest that simvastatin combined with lisdexamfetamine dimesylate induced a significant increased locomotion and lisdexamfetamine dimesylate administration causes an oxidative imbalance determined by an increment in lipid peroxidation, protein oxidation and alterations in the activities of antioxidant enzymes in brain areas; moreover, in the presence of simvastatin, most of these effects were prevented. These findings contribute to a better understanding of the critical roles of lisdexamfetamine dimesylate in the treatment of neuropsychiatric disorders, associated with increased oxidative stress and changes in antioxidant enzymatic defense. In view of the central role played by lisdexamfetamine dimesylate, the established antioxidant effect of simvastatin therapy is of major interest. |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016-03-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652016000100335 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652016000100335 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/0001-3765201620140490 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Academia Brasileira de Ciências |
publisher.none.fl_str_mv |
Academia Brasileira de Ciências |
dc.source.none.fl_str_mv |
Anais da Academia Brasileira de Ciências v.88 n.1 2016 reponame:Anais da Academia Brasileira de Ciências (Online) instname:Academia Brasileira de Ciências (ABC) instacron:ABC |
instname_str |
Academia Brasileira de Ciências (ABC) |
instacron_str |
ABC |
institution |
ABC |
reponame_str |
Anais da Academia Brasileira de Ciências (Online) |
collection |
Anais da Academia Brasileira de Ciências (Online) |
repository.name.fl_str_mv |
Anais da Academia Brasileira de Ciências (Online) - Academia Brasileira de Ciências (ABC) |
repository.mail.fl_str_mv |
||aabc@abc.org.br |
_version_ |
1754302862736752640 |