Algae as a source of peptides inhibitors of the angiotensin-converting enzyme: a systematic review
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Anais da Academia Brasileira de Ciências (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652022000300901 |
Resumo: | Abstract Hypertension is a factor that contributes to the risk of chronic diseases. The inhibition of angiotensin-I converting enzyme (ACE) is a useful therapeutic approach to the hypertension treatment. The algae have been an alternative for the production of ACE inhibitory (ACEi) peptides from enzymatic hydrolysis due to their protein-rich biomass. The aim of this study was to systematically review the literature regarding the production, composition and activity of ACEi peptides derived from algae proteins. Systematic database searches identified 648 related articles. Among these, only 14 were selected according to the eligibility criteria to this review. Macroalgae are more studied than microalgae as sources of ACEi peptides. Furthermore, hydrolysates by thermolysin or bromelain exhibited the highest ACEi activity compared to other enzymes. The main features of the peptides with high ACE inhibition are low molecular weight, short amino acids sequence and non-competitive inhibition pattern. In vivo studies using hydrolysates and peptides derived from algae proteins showed antihypertensive activity in spontaneously hypertensive rats (SHR). Thus, it is suggested that ACEi peptides derived from algae can be considered as potential antihypertensive. |
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Algae as a source of peptides inhibitors of the angiotensin-converting enzyme: a systematic reviewAlgae protein hydrolysateanti-hypertensionbioactive peptideshypertensioninhibitory peptideAbstract Hypertension is a factor that contributes to the risk of chronic diseases. The inhibition of angiotensin-I converting enzyme (ACE) is a useful therapeutic approach to the hypertension treatment. The algae have been an alternative for the production of ACE inhibitory (ACEi) peptides from enzymatic hydrolysis due to their protein-rich biomass. The aim of this study was to systematically review the literature regarding the production, composition and activity of ACEi peptides derived from algae proteins. Systematic database searches identified 648 related articles. Among these, only 14 were selected according to the eligibility criteria to this review. Macroalgae are more studied than microalgae as sources of ACEi peptides. Furthermore, hydrolysates by thermolysin or bromelain exhibited the highest ACEi activity compared to other enzymes. The main features of the peptides with high ACE inhibition are low molecular weight, short amino acids sequence and non-competitive inhibition pattern. In vivo studies using hydrolysates and peptides derived from algae proteins showed antihypertensive activity in spontaneously hypertensive rats (SHR). Thus, it is suggested that ACEi peptides derived from algae can be considered as potential antihypertensive.Academia Brasileira de Ciências2022-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652022000300901Anais da Academia Brasileira de Ciências v.94 n.2 2022reponame:Anais da Academia Brasileira de Ciências (Online)instname:Academia Brasileira de Ciências (ABC)instacron:ABC10.1590/0001-3765202220201636info:eu-repo/semantics/openAccessAMORIM,ANDREZA P. DESILVA,GABRIELLY H. DABRANDÃO,ROMERO M. P.PORTO,ANA LÚCIA F.BEZERRA,RAQUEL P.eng2022-03-16T00:00:00Zoai:scielo:S0001-37652022000300901Revistahttp://www.scielo.br/aabchttps://old.scielo.br/oai/scielo-oai.php||aabc@abc.org.br1678-26900001-3765opendoar:2022-03-16T00:00Anais da Academia Brasileira de Ciências (Online) - Academia Brasileira de Ciências (ABC)false |
dc.title.none.fl_str_mv |
Algae as a source of peptides inhibitors of the angiotensin-converting enzyme: a systematic review |
title |
Algae as a source of peptides inhibitors of the angiotensin-converting enzyme: a systematic review |
spellingShingle |
Algae as a source of peptides inhibitors of the angiotensin-converting enzyme: a systematic review AMORIM,ANDREZA P. DE Algae protein hydrolysate anti-hypertension bioactive peptides hypertension inhibitory peptide |
title_short |
Algae as a source of peptides inhibitors of the angiotensin-converting enzyme: a systematic review |
title_full |
Algae as a source of peptides inhibitors of the angiotensin-converting enzyme: a systematic review |
title_fullStr |
Algae as a source of peptides inhibitors of the angiotensin-converting enzyme: a systematic review |
title_full_unstemmed |
Algae as a source of peptides inhibitors of the angiotensin-converting enzyme: a systematic review |
title_sort |
Algae as a source of peptides inhibitors of the angiotensin-converting enzyme: a systematic review |
author |
AMORIM,ANDREZA P. DE |
author_facet |
AMORIM,ANDREZA P. DE SILVA,GABRIELLY H. DA BRANDÃO,ROMERO M. P. PORTO,ANA LÚCIA F. BEZERRA,RAQUEL P. |
author_role |
author |
author2 |
SILVA,GABRIELLY H. DA BRANDÃO,ROMERO M. P. PORTO,ANA LÚCIA F. BEZERRA,RAQUEL P. |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
AMORIM,ANDREZA P. DE SILVA,GABRIELLY H. DA BRANDÃO,ROMERO M. P. PORTO,ANA LÚCIA F. BEZERRA,RAQUEL P. |
dc.subject.por.fl_str_mv |
Algae protein hydrolysate anti-hypertension bioactive peptides hypertension inhibitory peptide |
topic |
Algae protein hydrolysate anti-hypertension bioactive peptides hypertension inhibitory peptide |
description |
Abstract Hypertension is a factor that contributes to the risk of chronic diseases. The inhibition of angiotensin-I converting enzyme (ACE) is a useful therapeutic approach to the hypertension treatment. The algae have been an alternative for the production of ACE inhibitory (ACEi) peptides from enzymatic hydrolysis due to their protein-rich biomass. The aim of this study was to systematically review the literature regarding the production, composition and activity of ACEi peptides derived from algae proteins. Systematic database searches identified 648 related articles. Among these, only 14 were selected according to the eligibility criteria to this review. Macroalgae are more studied than microalgae as sources of ACEi peptides. Furthermore, hydrolysates by thermolysin or bromelain exhibited the highest ACEi activity compared to other enzymes. The main features of the peptides with high ACE inhibition are low molecular weight, short amino acids sequence and non-competitive inhibition pattern. In vivo studies using hydrolysates and peptides derived from algae proteins showed antihypertensive activity in spontaneously hypertensive rats (SHR). Thus, it is suggested that ACEi peptides derived from algae can be considered as potential antihypertensive. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652022000300901 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652022000300901 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/0001-3765202220201636 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Academia Brasileira de Ciências |
publisher.none.fl_str_mv |
Academia Brasileira de Ciências |
dc.source.none.fl_str_mv |
Anais da Academia Brasileira de Ciências v.94 n.2 2022 reponame:Anais da Academia Brasileira de Ciências (Online) instname:Academia Brasileira de Ciências (ABC) instacron:ABC |
instname_str |
Academia Brasileira de Ciências (ABC) |
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ABC |
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ABC |
reponame_str |
Anais da Academia Brasileira de Ciências (Online) |
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Anais da Academia Brasileira de Ciências (Online) |
repository.name.fl_str_mv |
Anais da Academia Brasileira de Ciências (Online) - Academia Brasileira de Ciências (ABC) |
repository.mail.fl_str_mv |
||aabc@abc.org.br |
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1754302872017698816 |