New enamine derivatives of lapachol and biological activity

Detalhes bibliográficos
Autor(a) principal: OLIVEIRA,MAILCAR F.
Data de Publicação: 2002
Outros Autores: LEMOS,TELMA L.G., MATTOS,MARCOS C. DE, SEGUNDO,TACIANA A., SANTIAGO,GILVANDETE M.P., BRAZ-FILHO,RAIMUNDO
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Anais da Academia Brasileira de Ciências (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652002000200004
Resumo: A convenient synthesis of the new enamine derivatives 2-(4-morpholinyl)-3-(3-methyl-2-butenyl)-1,4-naphthalenedione, 2-(1-piperidinyl)-3-(3-methyl-2-butenyl)-1,4-naphtalenedione and 2-(1-pyrrolidinyl)-3-(3-methyl-2-butenyl)-1,4-naphthalenedione was carried out from natural 2-hydroxy-3-(3-methyl-2-butenyl)-1,4-naphthalenedione (lapachol) and morpholine, piperidine and pyrrolidine. The structures of the products were established mainly by NMR analysis, including 2D experiments. Biological activities of these products were evaluated against Artemia salina, Aedes aegypti and cytotoxicity using A549 human breast cells.
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spelling New enamine derivatives of lapachol and biological activitylapacholenamine derivativesbiological activitiesA convenient synthesis of the new enamine derivatives 2-(4-morpholinyl)-3-(3-methyl-2-butenyl)-1,4-naphthalenedione, 2-(1-piperidinyl)-3-(3-methyl-2-butenyl)-1,4-naphtalenedione and 2-(1-pyrrolidinyl)-3-(3-methyl-2-butenyl)-1,4-naphthalenedione was carried out from natural 2-hydroxy-3-(3-methyl-2-butenyl)-1,4-naphthalenedione (lapachol) and morpholine, piperidine and pyrrolidine. The structures of the products were established mainly by NMR analysis, including 2D experiments. Biological activities of these products were evaluated against Artemia salina, Aedes aegypti and cytotoxicity using A549 human breast cells.Academia Brasileira de Ciências2002-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652002000200004Anais da Academia Brasileira de Ciências v.74 n.2 2002reponame:Anais da Academia Brasileira de Ciências (Online)instname:Academia Brasileira de Ciências (ABC)instacron:ABC10.1590/S0001-37652002000200004info:eu-repo/semantics/openAccessOLIVEIRA,MAILCAR F.LEMOS,TELMA L.G.MATTOS,MARCOS C. DESEGUNDO,TACIANA A.SANTIAGO,GILVANDETE M.P.BRAZ-FILHO,RAIMUNDOeng2002-07-17T00:00:00Zoai:scielo:S0001-37652002000200004Revistahttp://www.scielo.br/aabchttps://old.scielo.br/oai/scielo-oai.php||aabc@abc.org.br1678-26900001-3765opendoar:2002-07-17T00:00Anais da Academia Brasileira de Ciências (Online) - Academia Brasileira de Ciências (ABC)false
dc.title.none.fl_str_mv New enamine derivatives of lapachol and biological activity
title New enamine derivatives of lapachol and biological activity
spellingShingle New enamine derivatives of lapachol and biological activity
OLIVEIRA,MAILCAR F.
lapachol
enamine derivatives
biological activities
title_short New enamine derivatives of lapachol and biological activity
title_full New enamine derivatives of lapachol and biological activity
title_fullStr New enamine derivatives of lapachol and biological activity
title_full_unstemmed New enamine derivatives of lapachol and biological activity
title_sort New enamine derivatives of lapachol and biological activity
author OLIVEIRA,MAILCAR F.
author_facet OLIVEIRA,MAILCAR F.
LEMOS,TELMA L.G.
MATTOS,MARCOS C. DE
SEGUNDO,TACIANA A.
SANTIAGO,GILVANDETE M.P.
BRAZ-FILHO,RAIMUNDO
author_role author
author2 LEMOS,TELMA L.G.
MATTOS,MARCOS C. DE
SEGUNDO,TACIANA A.
SANTIAGO,GILVANDETE M.P.
BRAZ-FILHO,RAIMUNDO
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv OLIVEIRA,MAILCAR F.
LEMOS,TELMA L.G.
MATTOS,MARCOS C. DE
SEGUNDO,TACIANA A.
SANTIAGO,GILVANDETE M.P.
BRAZ-FILHO,RAIMUNDO
dc.subject.por.fl_str_mv lapachol
enamine derivatives
biological activities
topic lapachol
enamine derivatives
biological activities
description A convenient synthesis of the new enamine derivatives 2-(4-morpholinyl)-3-(3-methyl-2-butenyl)-1,4-naphthalenedione, 2-(1-piperidinyl)-3-(3-methyl-2-butenyl)-1,4-naphtalenedione and 2-(1-pyrrolidinyl)-3-(3-methyl-2-butenyl)-1,4-naphthalenedione was carried out from natural 2-hydroxy-3-(3-methyl-2-butenyl)-1,4-naphthalenedione (lapachol) and morpholine, piperidine and pyrrolidine. The structures of the products were established mainly by NMR analysis, including 2D experiments. Biological activities of these products were evaluated against Artemia salina, Aedes aegypti and cytotoxicity using A549 human breast cells.
publishDate 2002
dc.date.none.fl_str_mv 2002-06-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652002000200004
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652002000200004
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0001-37652002000200004
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Academia Brasileira de Ciências
publisher.none.fl_str_mv Academia Brasileira de Ciências
dc.source.none.fl_str_mv Anais da Academia Brasileira de Ciências v.74 n.2 2002
reponame:Anais da Academia Brasileira de Ciências (Online)
instname:Academia Brasileira de Ciências (ABC)
instacron:ABC
instname_str Academia Brasileira de Ciências (ABC)
instacron_str ABC
institution ABC
reponame_str Anais da Academia Brasileira de Ciências (Online)
collection Anais da Academia Brasileira de Ciências (Online)
repository.name.fl_str_mv Anais da Academia Brasileira de Ciências (Online) - Academia Brasileira de Ciências (ABC)
repository.mail.fl_str_mv ||aabc@abc.org.br
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