Impact of continuous flow chemistry in the synthesis of natural products and active pharmaceutical ingredients

Detalhes bibliográficos
Autor(a) principal: SOUZA,JULIANA M. DE
Data de Publicação: 2018
Outros Autores: GALAVERNA,RENAN, SOUZA,ALINE A.N. DE, BROCKSOM,TIMOTHY J., PASTRE,JULIO C., SOUZA,RODRIGO O.M.A. DE, OLIVEIRA,KLEBER T. DE
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Anais da Academia Brasileira de Ciências (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652018000301131
Resumo: ABSTRACT We present a comprehensive review of the advent and impact of continuous flow chemistry with regard to the synthesis of natural products and drugs, important pharmaceutical products and definitely responsible for a revolution in modern healthcare. We detail the beginnings of modern drugs and the large scale batch mode of production, both chemical and microbiological. The introduction of modern continuous flow chemistry is then presented, both as a technological tool for enabling organic chemistry, and as a fundamental research endeavor. This part details the syntheses of bioactive natural products and commercial drugs.
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spelling Impact of continuous flow chemistry in the synthesis of natural products and active pharmaceutical ingredientsContinuous flownatural productsAPIssynthesisABSTRACT We present a comprehensive review of the advent and impact of continuous flow chemistry with regard to the synthesis of natural products and drugs, important pharmaceutical products and definitely responsible for a revolution in modern healthcare. We detail the beginnings of modern drugs and the large scale batch mode of production, both chemical and microbiological. The introduction of modern continuous flow chemistry is then presented, both as a technological tool for enabling organic chemistry, and as a fundamental research endeavor. This part details the syntheses of bioactive natural products and commercial drugs.Academia Brasileira de Ciências2018-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652018000301131Anais da Academia Brasileira de Ciências v.90 n.1 suppl.2 2018reponame:Anais da Academia Brasileira de Ciências (Online)instname:Academia Brasileira de Ciências (ABC)instacron:ABC10.1590/0001-3765201820170778info:eu-repo/semantics/openAccessSOUZA,JULIANA M. DEGALAVERNA,RENANSOUZA,ALINE A.N. DEBROCKSOM,TIMOTHY J.PASTRE,JULIO C.SOUZA,RODRIGO O.M.A. DEOLIVEIRA,KLEBER T. DEeng2018-05-28T00:00:00Zoai:scielo:S0001-37652018000301131Revistahttp://www.scielo.br/aabchttps://old.scielo.br/oai/scielo-oai.php||aabc@abc.org.br1678-26900001-3765opendoar:2018-05-28T00:00Anais da Academia Brasileira de Ciências (Online) - Academia Brasileira de Ciências (ABC)false
dc.title.none.fl_str_mv Impact of continuous flow chemistry in the synthesis of natural products and active pharmaceutical ingredients
title Impact of continuous flow chemistry in the synthesis of natural products and active pharmaceutical ingredients
spellingShingle Impact of continuous flow chemistry in the synthesis of natural products and active pharmaceutical ingredients
SOUZA,JULIANA M. DE
Continuous flow
natural products
APIs
synthesis
title_short Impact of continuous flow chemistry in the synthesis of natural products and active pharmaceutical ingredients
title_full Impact of continuous flow chemistry in the synthesis of natural products and active pharmaceutical ingredients
title_fullStr Impact of continuous flow chemistry in the synthesis of natural products and active pharmaceutical ingredients
title_full_unstemmed Impact of continuous flow chemistry in the synthesis of natural products and active pharmaceutical ingredients
title_sort Impact of continuous flow chemistry in the synthesis of natural products and active pharmaceutical ingredients
author SOUZA,JULIANA M. DE
author_facet SOUZA,JULIANA M. DE
GALAVERNA,RENAN
SOUZA,ALINE A.N. DE
BROCKSOM,TIMOTHY J.
PASTRE,JULIO C.
SOUZA,RODRIGO O.M.A. DE
OLIVEIRA,KLEBER T. DE
author_role author
author2 GALAVERNA,RENAN
SOUZA,ALINE A.N. DE
BROCKSOM,TIMOTHY J.
PASTRE,JULIO C.
SOUZA,RODRIGO O.M.A. DE
OLIVEIRA,KLEBER T. DE
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv SOUZA,JULIANA M. DE
GALAVERNA,RENAN
SOUZA,ALINE A.N. DE
BROCKSOM,TIMOTHY J.
PASTRE,JULIO C.
SOUZA,RODRIGO O.M.A. DE
OLIVEIRA,KLEBER T. DE
dc.subject.por.fl_str_mv Continuous flow
natural products
APIs
synthesis
topic Continuous flow
natural products
APIs
synthesis
description ABSTRACT We present a comprehensive review of the advent and impact of continuous flow chemistry with regard to the synthesis of natural products and drugs, important pharmaceutical products and definitely responsible for a revolution in modern healthcare. We detail the beginnings of modern drugs and the large scale batch mode of production, both chemical and microbiological. The introduction of modern continuous flow chemistry is then presented, both as a technological tool for enabling organic chemistry, and as a fundamental research endeavor. This part details the syntheses of bioactive natural products and commercial drugs.
publishDate 2018
dc.date.none.fl_str_mv 2018-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652018000301131
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652018000301131
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/0001-3765201820170778
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Academia Brasileira de Ciências
publisher.none.fl_str_mv Academia Brasileira de Ciências
dc.source.none.fl_str_mv Anais da Academia Brasileira de Ciências v.90 n.1 suppl.2 2018
reponame:Anais da Academia Brasileira de Ciências (Online)
instname:Academia Brasileira de Ciências (ABC)
instacron:ABC
instname_str Academia Brasileira de Ciências (ABC)
instacron_str ABC
institution ABC
reponame_str Anais da Academia Brasileira de Ciências (Online)
collection Anais da Academia Brasileira de Ciências (Online)
repository.name.fl_str_mv Anais da Academia Brasileira de Ciências (Online) - Academia Brasileira de Ciências (ABC)
repository.mail.fl_str_mv ||aabc@abc.org.br
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