Impact of continuous flow chemistry in the synthesis of natural products and active pharmaceutical ingredients
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Anais da Academia Brasileira de Ciências (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652018000301131 |
Resumo: | ABSTRACT We present a comprehensive review of the advent and impact of continuous flow chemistry with regard to the synthesis of natural products and drugs, important pharmaceutical products and definitely responsible for a revolution in modern healthcare. We detail the beginnings of modern drugs and the large scale batch mode of production, both chemical and microbiological. The introduction of modern continuous flow chemistry is then presented, both as a technological tool for enabling organic chemistry, and as a fundamental research endeavor. This part details the syntheses of bioactive natural products and commercial drugs. |
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Impact of continuous flow chemistry in the synthesis of natural products and active pharmaceutical ingredientsContinuous flownatural productsAPIssynthesisABSTRACT We present a comprehensive review of the advent and impact of continuous flow chemistry with regard to the synthesis of natural products and drugs, important pharmaceutical products and definitely responsible for a revolution in modern healthcare. We detail the beginnings of modern drugs and the large scale batch mode of production, both chemical and microbiological. The introduction of modern continuous flow chemistry is then presented, both as a technological tool for enabling organic chemistry, and as a fundamental research endeavor. This part details the syntheses of bioactive natural products and commercial drugs.Academia Brasileira de Ciências2018-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652018000301131Anais da Academia Brasileira de Ciências v.90 n.1 suppl.2 2018reponame:Anais da Academia Brasileira de Ciências (Online)instname:Academia Brasileira de Ciências (ABC)instacron:ABC10.1590/0001-3765201820170778info:eu-repo/semantics/openAccessSOUZA,JULIANA M. DEGALAVERNA,RENANSOUZA,ALINE A.N. DEBROCKSOM,TIMOTHY J.PASTRE,JULIO C.SOUZA,RODRIGO O.M.A. DEOLIVEIRA,KLEBER T. DEeng2018-05-28T00:00:00Zoai:scielo:S0001-37652018000301131Revistahttp://www.scielo.br/aabchttps://old.scielo.br/oai/scielo-oai.php||aabc@abc.org.br1678-26900001-3765opendoar:2018-05-28T00:00Anais da Academia Brasileira de Ciências (Online) - Academia Brasileira de Ciências (ABC)false |
dc.title.none.fl_str_mv |
Impact of continuous flow chemistry in the synthesis of natural products and active pharmaceutical ingredients |
title |
Impact of continuous flow chemistry in the synthesis of natural products and active pharmaceutical ingredients |
spellingShingle |
Impact of continuous flow chemistry in the synthesis of natural products and active pharmaceutical ingredients SOUZA,JULIANA M. DE Continuous flow natural products APIs synthesis |
title_short |
Impact of continuous flow chemistry in the synthesis of natural products and active pharmaceutical ingredients |
title_full |
Impact of continuous flow chemistry in the synthesis of natural products and active pharmaceutical ingredients |
title_fullStr |
Impact of continuous flow chemistry in the synthesis of natural products and active pharmaceutical ingredients |
title_full_unstemmed |
Impact of continuous flow chemistry in the synthesis of natural products and active pharmaceutical ingredients |
title_sort |
Impact of continuous flow chemistry in the synthesis of natural products and active pharmaceutical ingredients |
author |
SOUZA,JULIANA M. DE |
author_facet |
SOUZA,JULIANA M. DE GALAVERNA,RENAN SOUZA,ALINE A.N. DE BROCKSOM,TIMOTHY J. PASTRE,JULIO C. SOUZA,RODRIGO O.M.A. DE OLIVEIRA,KLEBER T. DE |
author_role |
author |
author2 |
GALAVERNA,RENAN SOUZA,ALINE A.N. DE BROCKSOM,TIMOTHY J. PASTRE,JULIO C. SOUZA,RODRIGO O.M.A. DE OLIVEIRA,KLEBER T. DE |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
SOUZA,JULIANA M. DE GALAVERNA,RENAN SOUZA,ALINE A.N. DE BROCKSOM,TIMOTHY J. PASTRE,JULIO C. SOUZA,RODRIGO O.M.A. DE OLIVEIRA,KLEBER T. DE |
dc.subject.por.fl_str_mv |
Continuous flow natural products APIs synthesis |
topic |
Continuous flow natural products APIs synthesis |
description |
ABSTRACT We present a comprehensive review of the advent and impact of continuous flow chemistry with regard to the synthesis of natural products and drugs, important pharmaceutical products and definitely responsible for a revolution in modern healthcare. We detail the beginnings of modern drugs and the large scale batch mode of production, both chemical and microbiological. The introduction of modern continuous flow chemistry is then presented, both as a technological tool for enabling organic chemistry, and as a fundamental research endeavor. This part details the syntheses of bioactive natural products and commercial drugs. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652018000301131 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652018000301131 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/0001-3765201820170778 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Academia Brasileira de Ciências |
publisher.none.fl_str_mv |
Academia Brasileira de Ciências |
dc.source.none.fl_str_mv |
Anais da Academia Brasileira de Ciências v.90 n.1 suppl.2 2018 reponame:Anais da Academia Brasileira de Ciências (Online) instname:Academia Brasileira de Ciências (ABC) instacron:ABC |
instname_str |
Academia Brasileira de Ciências (ABC) |
instacron_str |
ABC |
institution |
ABC |
reponame_str |
Anais da Academia Brasileira de Ciências (Online) |
collection |
Anais da Academia Brasileira de Ciências (Online) |
repository.name.fl_str_mv |
Anais da Academia Brasileira de Ciências (Online) - Academia Brasileira de Ciências (ABC) |
repository.mail.fl_str_mv |
||aabc@abc.org.br |
_version_ |
1754302865601462272 |