Reduction of blood nitric oxide levels is associated with clinical improvement of the chronic pelvic pain related to endometriosis
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Brazilian Journal of Medical and Biological Research |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2015000400363 |
Resumo: | The objective of this prospective study was to determine the plasma levels of nitric oxide (NO) in women with chronic pelvic pain secondary to endometriosis (n=24) and abdominal myofascial pain syndrome (n=16). NO levels were measured in plasma collected before and 1 month after treatment. Pretreatment NO levels (μM) were lower in healthy volunteers (47.0±12.7) than in women with myofascial pain (64.2±5.0, P=0.01) or endometriosis (99.5±12.9, P<0.0001). After treatment, plasma NO levels were reduced only in the endometriosis group (99.5±12.9 vs 61.6±5.9, P=0.002). A correlation between reduction of pain intensity and reduction of NO level was observed in the endometriosis group [correlation = 0.67 (95%CI = 0.35 to 0.85), P<0.0001]. Reduction of NO levels was associated with an increase of pain threshold in this group [correlation = -0.53 (-0.78 to -0.14), P<0.0001]. NO levels appeared elevated in women with chronic pelvic pain diagnosed as secondary to endometriosis, and were directly associated with reduction in pain intensity and increase in pain threshold after treatment. Further studies are needed to investigate the role of NO in the pathophysiology of pain in women with endometriosis and its eventual association with central sensitization. |
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Brazilian Journal of Medical and Biological Research |
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Reduction of blood nitric oxide levels is associated with clinical improvement of the chronic pelvic pain related to endometriosisChronic pelvic painEndometriosisAbdominal myofascial pain syndromeNitric oxideInflammationCentral sensitizationThe objective of this prospective study was to determine the plasma levels of nitric oxide (NO) in women with chronic pelvic pain secondary to endometriosis (n=24) and abdominal myofascial pain syndrome (n=16). NO levels were measured in plasma collected before and 1 month after treatment. Pretreatment NO levels (μM) were lower in healthy volunteers (47.0±12.7) than in women with myofascial pain (64.2±5.0, P=0.01) or endometriosis (99.5±12.9, P<0.0001). After treatment, plasma NO levels were reduced only in the endometriosis group (99.5±12.9 vs 61.6±5.9, P=0.002). A correlation between reduction of pain intensity and reduction of NO level was observed in the endometriosis group [correlation = 0.67 (95%CI = 0.35 to 0.85), P<0.0001]. Reduction of NO levels was associated with an increase of pain threshold in this group [correlation = -0.53 (-0.78 to -0.14), P<0.0001]. NO levels appeared elevated in women with chronic pelvic pain diagnosed as secondary to endometriosis, and were directly associated with reduction in pain intensity and increase in pain threshold after treatment. Further studies are needed to investigate the role of NO in the pathophysiology of pain in women with endometriosis and its eventual association with central sensitization.Associação Brasileira de Divulgação Científica2015-04-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2015000400363Brazilian Journal of Medical and Biological Research v.48 n.4 2015reponame:Brazilian Journal of Medical and Biological Researchinstname:Associação Brasileira de Divulgação Científica (ABDC)instacron:ABDC10.1590/1414-431x20143619info:eu-repo/semantics/openAccessRocha,M.G.Gomes,V.A.Tanus-Santos,J.E.Rosa-e-Silva,J.C.Candido-dos-Reis,F.J.Nogueira,A.A.Poli-Neto,O.B.eng2019-03-19T00:00:00Zoai:scielo:S0100-879X2015000400363Revistahttps://www.bjournal.org/https://old.scielo.br/oai/scielo-oai.phpbjournal@terra.com.br||bjournal@terra.com.br1414-431X0100-879Xopendoar:2019-03-19T00:00Brazilian Journal of Medical and Biological Research - Associação Brasileira de Divulgação Científica (ABDC)false |
dc.title.none.fl_str_mv |
Reduction of blood nitric oxide levels is associated with clinical improvement of the chronic pelvic pain related to endometriosis |
title |
Reduction of blood nitric oxide levels is associated with clinical improvement of the chronic pelvic pain related to endometriosis |
spellingShingle |
Reduction of blood nitric oxide levels is associated with clinical improvement of the chronic pelvic pain related to endometriosis Rocha,M.G. Chronic pelvic pain Endometriosis Abdominal myofascial pain syndrome Nitric oxide Inflammation Central sensitization |
title_short |
Reduction of blood nitric oxide levels is associated with clinical improvement of the chronic pelvic pain related to endometriosis |
title_full |
Reduction of blood nitric oxide levels is associated with clinical improvement of the chronic pelvic pain related to endometriosis |
title_fullStr |
Reduction of blood nitric oxide levels is associated with clinical improvement of the chronic pelvic pain related to endometriosis |
title_full_unstemmed |
Reduction of blood nitric oxide levels is associated with clinical improvement of the chronic pelvic pain related to endometriosis |
title_sort |
Reduction of blood nitric oxide levels is associated with clinical improvement of the chronic pelvic pain related to endometriosis |
author |
Rocha,M.G. |
author_facet |
Rocha,M.G. Gomes,V.A. Tanus-Santos,J.E. Rosa-e-Silva,J.C. Candido-dos-Reis,F.J. Nogueira,A.A. Poli-Neto,O.B. |
author_role |
author |
author2 |
Gomes,V.A. Tanus-Santos,J.E. Rosa-e-Silva,J.C. Candido-dos-Reis,F.J. Nogueira,A.A. Poli-Neto,O.B. |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Rocha,M.G. Gomes,V.A. Tanus-Santos,J.E. Rosa-e-Silva,J.C. Candido-dos-Reis,F.J. Nogueira,A.A. Poli-Neto,O.B. |
dc.subject.por.fl_str_mv |
Chronic pelvic pain Endometriosis Abdominal myofascial pain syndrome Nitric oxide Inflammation Central sensitization |
topic |
Chronic pelvic pain Endometriosis Abdominal myofascial pain syndrome Nitric oxide Inflammation Central sensitization |
description |
The objective of this prospective study was to determine the plasma levels of nitric oxide (NO) in women with chronic pelvic pain secondary to endometriosis (n=24) and abdominal myofascial pain syndrome (n=16). NO levels were measured in plasma collected before and 1 month after treatment. Pretreatment NO levels (μM) were lower in healthy volunteers (47.0±12.7) than in women with myofascial pain (64.2±5.0, P=0.01) or endometriosis (99.5±12.9, P<0.0001). After treatment, plasma NO levels were reduced only in the endometriosis group (99.5±12.9 vs 61.6±5.9, P=0.002). A correlation between reduction of pain intensity and reduction of NO level was observed in the endometriosis group [correlation = 0.67 (95%CI = 0.35 to 0.85), P<0.0001]. Reduction of NO levels was associated with an increase of pain threshold in this group [correlation = -0.53 (-0.78 to -0.14), P<0.0001]. NO levels appeared elevated in women with chronic pelvic pain diagnosed as secondary to endometriosis, and were directly associated with reduction in pain intensity and increase in pain threshold after treatment. Further studies are needed to investigate the role of NO in the pathophysiology of pain in women with endometriosis and its eventual association with central sensitization. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015-04-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2015000400363 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2015000400363 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/1414-431x20143619 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Associação Brasileira de Divulgação Científica |
publisher.none.fl_str_mv |
Associação Brasileira de Divulgação Científica |
dc.source.none.fl_str_mv |
Brazilian Journal of Medical and Biological Research v.48 n.4 2015 reponame:Brazilian Journal of Medical and Biological Research instname:Associação Brasileira de Divulgação Científica (ABDC) instacron:ABDC |
instname_str |
Associação Brasileira de Divulgação Científica (ABDC) |
instacron_str |
ABDC |
institution |
ABDC |
reponame_str |
Brazilian Journal of Medical and Biological Research |
collection |
Brazilian Journal of Medical and Biological Research |
repository.name.fl_str_mv |
Brazilian Journal of Medical and Biological Research - Associação Brasileira de Divulgação Científica (ABDC) |
repository.mail.fl_str_mv |
bjournal@terra.com.br||bjournal@terra.com.br |
_version_ |
1754302944235225088 |