Correlation of serum leptin and insulin levels of pregnant protein-restricted rats with predictive obesity variables

Detalhes bibliográficos
Autor(a) principal: Macêdo,G.S.
Data de Publicação: 2008
Outros Autores: Ferreira,C.L.P., Menegaz,A., Arantes,V.C., Veloso,R.V., Carneiro,E.M., Boschero,A.C., Oller do Nascimento,C.M.P., Latorraca,M.Q., Gomes-da-Silva,M.H.G.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Brazilian Journal of Medical and Biological Research
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2008000600014
Resumo: During pregnancy and protein restriction, changes in serum insulin and leptin levels, food intake and several metabolic parameters normally result in enhanced adiposity. We evaluated serum leptin and insulin levels and their correlations with some predictive obesity variables in Wistar rats (90 days), up to the 14th day of pregnancy: control non-pregnant (N = 5) and pregnant (N = 7) groups (control diet: 17% protein), and low-protein non-pregnant (N = 5) and pregnant (N = 6) groups (low-protein diet: 6%). Independent of the protein content of the diet, pregnancy increased total (F1,19 = 22.28, P < 0.001) and relative (F1,19 = 5.57, P < 0.03) food intake, the variation of weight (F1,19 = 49.79, P < 0.000) and final body weight (F1,19 = 19.52, P < 0.001), but glycemia (F1,19 = 9.02, P = 0.01) and the relative weight of gonadal adipose tissue (F1,19 = 17.11, P < 0.001) were decreased. Pregnancy (F1,19 = 18.13, P < 0.001) and low-protein diet (F1,19 = 20.35, P < 0.001) increased the absolute weight of brown adipose tissue. However, the relative weight of this tissue was increased only by protein restriction (F1,19 = 15.20, P < 0.001) and the relative lipid in carcass was decreased in low-protein groups (F1,19 = 4.34, P = 0.05). Serum insulin and leptin levels were similar among groups and did not correlate with food intake. However, there was a positive relationship between serum insulin levels and carcass fat depots in low-protein groups (r = 0.37, P < 0.05), while in pregnancy serum leptin correlated with weight of gonadal (r = 0.39, P < 0.02) and retroperitoneal (r = 0.41, P < 0.01) adipose tissues. Unexpectedly, protein restriction during 14 days of pregnancy did not alter the serum profile of adiposity signals and their effects on food intake and adiposity, probably due to the short term of exposure to low-protein diet.
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spelling Correlation of serum leptin and insulin levels of pregnant protein-restricted rats with predictive obesity variablesLow-protein dietPregnancySerum leptinSerum insulinBody adiposityDuring pregnancy and protein restriction, changes in serum insulin and leptin levels, food intake and several metabolic parameters normally result in enhanced adiposity. We evaluated serum leptin and insulin levels and their correlations with some predictive obesity variables in Wistar rats (90 days), up to the 14th day of pregnancy: control non-pregnant (N = 5) and pregnant (N = 7) groups (control diet: 17% protein), and low-protein non-pregnant (N = 5) and pregnant (N = 6) groups (low-protein diet: 6%). Independent of the protein content of the diet, pregnancy increased total (F1,19 = 22.28, P < 0.001) and relative (F1,19 = 5.57, P < 0.03) food intake, the variation of weight (F1,19 = 49.79, P < 0.000) and final body weight (F1,19 = 19.52, P < 0.001), but glycemia (F1,19 = 9.02, P = 0.01) and the relative weight of gonadal adipose tissue (F1,19 = 17.11, P < 0.001) were decreased. Pregnancy (F1,19 = 18.13, P < 0.001) and low-protein diet (F1,19 = 20.35, P < 0.001) increased the absolute weight of brown adipose tissue. However, the relative weight of this tissue was increased only by protein restriction (F1,19 = 15.20, P < 0.001) and the relative lipid in carcass was decreased in low-protein groups (F1,19 = 4.34, P = 0.05). Serum insulin and leptin levels were similar among groups and did not correlate with food intake. However, there was a positive relationship between serum insulin levels and carcass fat depots in low-protein groups (r = 0.37, P < 0.05), while in pregnancy serum leptin correlated with weight of gonadal (r = 0.39, P < 0.02) and retroperitoneal (r = 0.41, P < 0.01) adipose tissues. Unexpectedly, protein restriction during 14 days of pregnancy did not alter the serum profile of adiposity signals and their effects on food intake and adiposity, probably due to the short term of exposure to low-protein diet.Associação Brasileira de Divulgação Científica2008-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2008000600014Brazilian Journal of Medical and Biological Research v.41 n.6 2008reponame:Brazilian Journal of Medical and Biological Researchinstname:Associação Brasileira de Divulgação Científica (ABDC)instacron:ABDC10.1590/S0100-879X2008000600014info:eu-repo/semantics/openAccessMacêdo,G.S.Ferreira,C.L.P.Menegaz,A.Arantes,V.C.Veloso,R.V.Carneiro,E.M.Boschero,A.C.Oller do Nascimento,C.M.P.Latorraca,M.Q.Gomes-da-Silva,M.H.G.eng2008-07-10T00:00:00Zoai:scielo:S0100-879X2008000600014Revistahttps://www.bjournal.org/https://old.scielo.br/oai/scielo-oai.phpbjournal@terra.com.br||bjournal@terra.com.br1414-431X0100-879Xopendoar:2008-07-10T00:00Brazilian Journal of Medical and Biological Research - Associação Brasileira de Divulgação Científica (ABDC)false
dc.title.none.fl_str_mv Correlation of serum leptin and insulin levels of pregnant protein-restricted rats with predictive obesity variables
title Correlation of serum leptin and insulin levels of pregnant protein-restricted rats with predictive obesity variables
spellingShingle Correlation of serum leptin and insulin levels of pregnant protein-restricted rats with predictive obesity variables
Macêdo,G.S.
Low-protein diet
Pregnancy
Serum leptin
Serum insulin
Body adiposity
title_short Correlation of serum leptin and insulin levels of pregnant protein-restricted rats with predictive obesity variables
title_full Correlation of serum leptin and insulin levels of pregnant protein-restricted rats with predictive obesity variables
title_fullStr Correlation of serum leptin and insulin levels of pregnant protein-restricted rats with predictive obesity variables
title_full_unstemmed Correlation of serum leptin and insulin levels of pregnant protein-restricted rats with predictive obesity variables
title_sort Correlation of serum leptin and insulin levels of pregnant protein-restricted rats with predictive obesity variables
author Macêdo,G.S.
author_facet Macêdo,G.S.
Ferreira,C.L.P.
Menegaz,A.
Arantes,V.C.
Veloso,R.V.
Carneiro,E.M.
Boschero,A.C.
Oller do Nascimento,C.M.P.
Latorraca,M.Q.
Gomes-da-Silva,M.H.G.
author_role author
author2 Ferreira,C.L.P.
Menegaz,A.
Arantes,V.C.
Veloso,R.V.
Carneiro,E.M.
Boschero,A.C.
Oller do Nascimento,C.M.P.
Latorraca,M.Q.
Gomes-da-Silva,M.H.G.
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Macêdo,G.S.
Ferreira,C.L.P.
Menegaz,A.
Arantes,V.C.
Veloso,R.V.
Carneiro,E.M.
Boschero,A.C.
Oller do Nascimento,C.M.P.
Latorraca,M.Q.
Gomes-da-Silva,M.H.G.
dc.subject.por.fl_str_mv Low-protein diet
Pregnancy
Serum leptin
Serum insulin
Body adiposity
topic Low-protein diet
Pregnancy
Serum leptin
Serum insulin
Body adiposity
description During pregnancy and protein restriction, changes in serum insulin and leptin levels, food intake and several metabolic parameters normally result in enhanced adiposity. We evaluated serum leptin and insulin levels and their correlations with some predictive obesity variables in Wistar rats (90 days), up to the 14th day of pregnancy: control non-pregnant (N = 5) and pregnant (N = 7) groups (control diet: 17% protein), and low-protein non-pregnant (N = 5) and pregnant (N = 6) groups (low-protein diet: 6%). Independent of the protein content of the diet, pregnancy increased total (F1,19 = 22.28, P < 0.001) and relative (F1,19 = 5.57, P < 0.03) food intake, the variation of weight (F1,19 = 49.79, P < 0.000) and final body weight (F1,19 = 19.52, P < 0.001), but glycemia (F1,19 = 9.02, P = 0.01) and the relative weight of gonadal adipose tissue (F1,19 = 17.11, P < 0.001) were decreased. Pregnancy (F1,19 = 18.13, P < 0.001) and low-protein diet (F1,19 = 20.35, P < 0.001) increased the absolute weight of brown adipose tissue. However, the relative weight of this tissue was increased only by protein restriction (F1,19 = 15.20, P < 0.001) and the relative lipid in carcass was decreased in low-protein groups (F1,19 = 4.34, P = 0.05). Serum insulin and leptin levels were similar among groups and did not correlate with food intake. However, there was a positive relationship between serum insulin levels and carcass fat depots in low-protein groups (r = 0.37, P < 0.05), while in pregnancy serum leptin correlated with weight of gonadal (r = 0.39, P < 0.02) and retroperitoneal (r = 0.41, P < 0.01) adipose tissues. Unexpectedly, protein restriction during 14 days of pregnancy did not alter the serum profile of adiposity signals and their effects on food intake and adiposity, probably due to the short term of exposure to low-protein diet.
publishDate 2008
dc.date.none.fl_str_mv 2008-06-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2008000600014
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2008000600014
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0100-879X2008000600014
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Associação Brasileira de Divulgação Científica
publisher.none.fl_str_mv Associação Brasileira de Divulgação Científica
dc.source.none.fl_str_mv Brazilian Journal of Medical and Biological Research v.41 n.6 2008
reponame:Brazilian Journal of Medical and Biological Research
instname:Associação Brasileira de Divulgação Científica (ABDC)
instacron:ABDC
instname_str Associação Brasileira de Divulgação Científica (ABDC)
instacron_str ABDC
institution ABDC
reponame_str Brazilian Journal of Medical and Biological Research
collection Brazilian Journal of Medical and Biological Research
repository.name.fl_str_mv Brazilian Journal of Medical and Biological Research - Associação Brasileira de Divulgação Científica (ABDC)
repository.mail.fl_str_mv bjournal@terra.com.br||bjournal@terra.com.br
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