Altered heart rate and blood pressure variability in mice lacking the Mas protooncogene

Detalhes bibliográficos
Autor(a) principal: Walther,T.
Data de Publicação: 2000
Outros Autores: Wessel,N., Kang,N., Sander,A., Tschöpe,C., Malberg,H., Bader,M., Voss,A.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Brazilian Journal of Medical and Biological Research
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2000000100001
Resumo: Heart rate variability is a relevant predictor of cardiovascular risk in humans. A significant genetic influence on heart rate variability is suggested, although the genes involved are ill-defined. The Mas-protooncogene encodes a G-protein-coupled receptor with seven transmembrane domains highly expressed in testis and brain. Since this receptor is supposed to interact with the signaling of angiotensin II, which is an important regulator of cardiovascular homeostasis, heart rate and blood pressure were analyzed in Mas-deficient mice. Using a femoral catheter the blood pressure of mice was measured for a period of 30 min and 250 data values per second were recorded. The mean values and range of heart rate and blood pressure were then calculated. Neither heart rate nor blood pressure were significantly different between knockout mice and controls. However, high resolution recording of these parameters and analysis of the data by non-linear dynamics revealed significant alterations in cardiovascular variability in Mas-deficient animals. In particular, females showed a strong reduction of heart rate variability. Furthermore, the data showed an increased sympathetic tone in knockout animals of both genders. The marked alterations detected in Mas-deficient mice of both genders suggest that the Mas-protooncogene is an important determinant of heart rate and blood pressure variability.
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spelling Altered heart rate and blood pressure variability in mice lacking the Mas protooncogeneblood pressure variabilityheart rate variabilitybaroreflex sensitivityMas protooncogeneHeart rate variability is a relevant predictor of cardiovascular risk in humans. A significant genetic influence on heart rate variability is suggested, although the genes involved are ill-defined. The Mas-protooncogene encodes a G-protein-coupled receptor with seven transmembrane domains highly expressed in testis and brain. Since this receptor is supposed to interact with the signaling of angiotensin II, which is an important regulator of cardiovascular homeostasis, heart rate and blood pressure were analyzed in Mas-deficient mice. Using a femoral catheter the blood pressure of mice was measured for a period of 30 min and 250 data values per second were recorded. The mean values and range of heart rate and blood pressure were then calculated. Neither heart rate nor blood pressure were significantly different between knockout mice and controls. However, high resolution recording of these parameters and analysis of the data by non-linear dynamics revealed significant alterations in cardiovascular variability in Mas-deficient animals. In particular, females showed a strong reduction of heart rate variability. Furthermore, the data showed an increased sympathetic tone in knockout animals of both genders. The marked alterations detected in Mas-deficient mice of both genders suggest that the Mas-protooncogene is an important determinant of heart rate and blood pressure variability.Associação Brasileira de Divulgação Científica2000-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2000000100001Brazilian Journal of Medical and Biological Research v.33 n.1 2000reponame:Brazilian Journal of Medical and Biological Researchinstname:Associação Brasileira de Divulgação Científica (ABDC)instacron:ABDC10.1590/S0100-879X2000000100001info:eu-repo/semantics/openAccessWalther,T.Wessel,N.Kang,N.Sander,A.Tschöpe,C.Malberg,H.Bader,M.Voss,A.eng2000-01-07T00:00:00Zoai:scielo:S0100-879X2000000100001Revistahttps://www.bjournal.org/https://old.scielo.br/oai/scielo-oai.phpbjournal@terra.com.br||bjournal@terra.com.br1414-431X0100-879Xopendoar:2000-01-07T00:00Brazilian Journal of Medical and Biological Research - Associação Brasileira de Divulgação Científica (ABDC)false
dc.title.none.fl_str_mv Altered heart rate and blood pressure variability in mice lacking the Mas protooncogene
title Altered heart rate and blood pressure variability in mice lacking the Mas protooncogene
spellingShingle Altered heart rate and blood pressure variability in mice lacking the Mas protooncogene
Walther,T.
blood pressure variability
heart rate variability
baroreflex sensitivity
Mas protooncogene
title_short Altered heart rate and blood pressure variability in mice lacking the Mas protooncogene
title_full Altered heart rate and blood pressure variability in mice lacking the Mas protooncogene
title_fullStr Altered heart rate and blood pressure variability in mice lacking the Mas protooncogene
title_full_unstemmed Altered heart rate and blood pressure variability in mice lacking the Mas protooncogene
title_sort Altered heart rate and blood pressure variability in mice lacking the Mas protooncogene
author Walther,T.
author_facet Walther,T.
Wessel,N.
Kang,N.
Sander,A.
Tschöpe,C.
Malberg,H.
Bader,M.
Voss,A.
author_role author
author2 Wessel,N.
Kang,N.
Sander,A.
Tschöpe,C.
Malberg,H.
Bader,M.
Voss,A.
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Walther,T.
Wessel,N.
Kang,N.
Sander,A.
Tschöpe,C.
Malberg,H.
Bader,M.
Voss,A.
dc.subject.por.fl_str_mv blood pressure variability
heart rate variability
baroreflex sensitivity
Mas protooncogene
topic blood pressure variability
heart rate variability
baroreflex sensitivity
Mas protooncogene
description Heart rate variability is a relevant predictor of cardiovascular risk in humans. A significant genetic influence on heart rate variability is suggested, although the genes involved are ill-defined. The Mas-protooncogene encodes a G-protein-coupled receptor with seven transmembrane domains highly expressed in testis and brain. Since this receptor is supposed to interact with the signaling of angiotensin II, which is an important regulator of cardiovascular homeostasis, heart rate and blood pressure were analyzed in Mas-deficient mice. Using a femoral catheter the blood pressure of mice was measured for a period of 30 min and 250 data values per second were recorded. The mean values and range of heart rate and blood pressure were then calculated. Neither heart rate nor blood pressure were significantly different between knockout mice and controls. However, high resolution recording of these parameters and analysis of the data by non-linear dynamics revealed significant alterations in cardiovascular variability in Mas-deficient animals. In particular, females showed a strong reduction of heart rate variability. Furthermore, the data showed an increased sympathetic tone in knockout animals of both genders. The marked alterations detected in Mas-deficient mice of both genders suggest that the Mas-protooncogene is an important determinant of heart rate and blood pressure variability.
publishDate 2000
dc.date.none.fl_str_mv 2000-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
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status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2000000100001
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2000000100001
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0100-879X2000000100001
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Associação Brasileira de Divulgação Científica
publisher.none.fl_str_mv Associação Brasileira de Divulgação Científica
dc.source.none.fl_str_mv Brazilian Journal of Medical and Biological Research v.33 n.1 2000
reponame:Brazilian Journal of Medical and Biological Research
instname:Associação Brasileira de Divulgação Científica (ABDC)
instacron:ABDC
instname_str Associação Brasileira de Divulgação Científica (ABDC)
instacron_str ABDC
institution ABDC
reponame_str Brazilian Journal of Medical and Biological Research
collection Brazilian Journal of Medical and Biological Research
repository.name.fl_str_mv Brazilian Journal of Medical and Biological Research - Associação Brasileira de Divulgação Científica (ABDC)
repository.mail.fl_str_mv bjournal@terra.com.br||bjournal@terra.com.br
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