IFN-g in human Chagas' disease: protection or pathology?
Autor(a) principal: | |
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Data de Publicação: | 1998 |
Outros Autores: | , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Brazilian Journal of Medical and Biological Research |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1998000100017 |
Resumo: | An apparently paradoxical role for IFN-<FONT FACE="Symbol">g</font> in human Chagas' disease was observed when studying the pattern of cytokine production by peripheral blood mononuclear cells (PBMC) obtained from two groups of chagasic patients after specific stimulation with Trypanosoma cruzi-derived antigens. The groups studied were 1) patients treated with benznidazole during the acute phase of Trypanosoma cruzi infection and 2) chronically infected untreated patients. In the treated group, higher levels of IFN-<FONT FACE="Symbol">g</font> were produced by PBMC from individuals cured after treatment when compared to non-cured patients. In contrast, in the chronically infected group (not treated) higher levels of IFN-<FONT FACE="Symbol">g</font> were produced by PBMC from cardiac patients in comparison with asymptomatic (indeterminate) patients. This apparently paradoxical role for IFN-<FONT FACE="Symbol">g</font> in human Chagas' disease is discussed in terms of the possibility of a temporal difference in IFN-<FONT FACE="Symbol">g</font> production during the initial stages of the infection (acute phase) in the presence or absence of chemotherapy. The maintenance of an immune response with high levels of IFN-<FONT FACE="Symbol">g</font> production during the chronic phase of the infection may favor cure or influence the development of the cardiac form of the disease |
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Brazilian Journal of Medical and Biological Research |
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IFN-g in human Chagas' disease: protection or pathology?Trypanosoma cruziChagas' diseasecardiomyopathyperipheral blood mononuclear cells (PBMC)cytokinesINF-<FONT FACE=Symbol>g</font>An apparently paradoxical role for IFN-<FONT FACE="Symbol">g</font> in human Chagas' disease was observed when studying the pattern of cytokine production by peripheral blood mononuclear cells (PBMC) obtained from two groups of chagasic patients after specific stimulation with Trypanosoma cruzi-derived antigens. The groups studied were 1) patients treated with benznidazole during the acute phase of Trypanosoma cruzi infection and 2) chronically infected untreated patients. In the treated group, higher levels of IFN-<FONT FACE="Symbol">g</font> were produced by PBMC from individuals cured after treatment when compared to non-cured patients. In contrast, in the chronically infected group (not treated) higher levels of IFN-<FONT FACE="Symbol">g</font> were produced by PBMC from cardiac patients in comparison with asymptomatic (indeterminate) patients. This apparently paradoxical role for IFN-<FONT FACE="Symbol">g</font> in human Chagas' disease is discussed in terms of the possibility of a temporal difference in IFN-<FONT FACE="Symbol">g</font> production during the initial stages of the infection (acute phase) in the presence or absence of chemotherapy. The maintenance of an immune response with high levels of IFN-<FONT FACE="Symbol">g</font> production during the chronic phase of the infection may favor cure or influence the development of the cardiac form of the diseaseAssociação Brasileira de Divulgação Científica1998-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1998000100017Brazilian Journal of Medical and Biological Research v.31 n.1 1998reponame:Brazilian Journal of Medical and Biological Researchinstname:Associação Brasileira de Divulgação Científica (ABDC)instacron:ABDC10.1590/S0100-879X1998000100017info:eu-repo/semantics/openAccessBahia-Oliveira,L.M.G.Gomes,J.A.S.Rocha,M.O.C.Moreira,M.C.V.Lemos,E.M.Luz,Z.M.P.Pereira,M.E.S.Coffman,R.L.Dias,J.C.P.Cançado,J.R.Gazzinelli,G.Corrêa-Oliveira,R.eng1998-10-07T00:00:00Zoai:scielo:S0100-879X1998000100017Revistahttps://www.bjournal.org/https://old.scielo.br/oai/scielo-oai.phpbjournal@terra.com.br||bjournal@terra.com.br1414-431X0100-879Xopendoar:1998-10-07T00:00Brazilian Journal of Medical and Biological Research - Associação Brasileira de Divulgação Científica (ABDC)false |
dc.title.none.fl_str_mv |
IFN-g in human Chagas' disease: protection or pathology? |
title |
IFN-g in human Chagas' disease: protection or pathology? |
spellingShingle |
IFN-g in human Chagas' disease: protection or pathology? Bahia-Oliveira,L.M.G. Trypanosoma cruzi Chagas' disease cardiomyopathy peripheral blood mononuclear cells (PBMC) cytokines INF-<FONT FACE=Symbol>g</font> |
title_short |
IFN-g in human Chagas' disease: protection or pathology? |
title_full |
IFN-g in human Chagas' disease: protection or pathology? |
title_fullStr |
IFN-g in human Chagas' disease: protection or pathology? |
title_full_unstemmed |
IFN-g in human Chagas' disease: protection or pathology? |
title_sort |
IFN-g in human Chagas' disease: protection or pathology? |
author |
Bahia-Oliveira,L.M.G. |
author_facet |
Bahia-Oliveira,L.M.G. Gomes,J.A.S. Rocha,M.O.C. Moreira,M.C.V. Lemos,E.M. Luz,Z.M.P. Pereira,M.E.S. Coffman,R.L. Dias,J.C.P. Cançado,J.R. Gazzinelli,G. Corrêa-Oliveira,R. |
author_role |
author |
author2 |
Gomes,J.A.S. Rocha,M.O.C. Moreira,M.C.V. Lemos,E.M. Luz,Z.M.P. Pereira,M.E.S. Coffman,R.L. Dias,J.C.P. Cançado,J.R. Gazzinelli,G. Corrêa-Oliveira,R. |
author2_role |
author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Bahia-Oliveira,L.M.G. Gomes,J.A.S. Rocha,M.O.C. Moreira,M.C.V. Lemos,E.M. Luz,Z.M.P. Pereira,M.E.S. Coffman,R.L. Dias,J.C.P. Cançado,J.R. Gazzinelli,G. Corrêa-Oliveira,R. |
dc.subject.por.fl_str_mv |
Trypanosoma cruzi Chagas' disease cardiomyopathy peripheral blood mononuclear cells (PBMC) cytokines INF-<FONT FACE=Symbol>g</font> |
topic |
Trypanosoma cruzi Chagas' disease cardiomyopathy peripheral blood mononuclear cells (PBMC) cytokines INF-<FONT FACE=Symbol>g</font> |
description |
An apparently paradoxical role for IFN-<FONT FACE="Symbol">g</font> in human Chagas' disease was observed when studying the pattern of cytokine production by peripheral blood mononuclear cells (PBMC) obtained from two groups of chagasic patients after specific stimulation with Trypanosoma cruzi-derived antigens. The groups studied were 1) patients treated with benznidazole during the acute phase of Trypanosoma cruzi infection and 2) chronically infected untreated patients. In the treated group, higher levels of IFN-<FONT FACE="Symbol">g</font> were produced by PBMC from individuals cured after treatment when compared to non-cured patients. In contrast, in the chronically infected group (not treated) higher levels of IFN-<FONT FACE="Symbol">g</font> were produced by PBMC from cardiac patients in comparison with asymptomatic (indeterminate) patients. This apparently paradoxical role for IFN-<FONT FACE="Symbol">g</font> in human Chagas' disease is discussed in terms of the possibility of a temporal difference in IFN-<FONT FACE="Symbol">g</font> production during the initial stages of the infection (acute phase) in the presence or absence of chemotherapy. The maintenance of an immune response with high levels of IFN-<FONT FACE="Symbol">g</font> production during the chronic phase of the infection may favor cure or influence the development of the cardiac form of the disease |
publishDate |
1998 |
dc.date.none.fl_str_mv |
1998-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1998000100017 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1998000100017 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0100-879X1998000100017 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Associação Brasileira de Divulgação Científica |
publisher.none.fl_str_mv |
Associação Brasileira de Divulgação Científica |
dc.source.none.fl_str_mv |
Brazilian Journal of Medical and Biological Research v.31 n.1 1998 reponame:Brazilian Journal of Medical and Biological Research instname:Associação Brasileira de Divulgação Científica (ABDC) instacron:ABDC |
instname_str |
Associação Brasileira de Divulgação Científica (ABDC) |
instacron_str |
ABDC |
institution |
ABDC |
reponame_str |
Brazilian Journal of Medical and Biological Research |
collection |
Brazilian Journal of Medical and Biological Research |
repository.name.fl_str_mv |
Brazilian Journal of Medical and Biological Research - Associação Brasileira de Divulgação Científica (ABDC) |
repository.mail.fl_str_mv |
bjournal@terra.com.br||bjournal@terra.com.br |
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1754302928926015488 |