Absorption mechanism of three curcumin constituents through in situ intestinal perfusion method

Detalhes bibliográficos
Autor(a) principal: Wang,Y.-H.
Data de Publicação: 2017
Outros Autores: Ke,X.-M., Zhang,C.-H., Yang,R.-P.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Brazilian Journal of Medical and Biological Research
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2017001100612
Resumo: This study aimed to investigate the absorption mechanism of three curcumin constituents in rat small intestines. Self-emulsification was used to solubilize the three curcumin constituents, and the rat in situ intestinal perfusion method was used to study factors on drug absorption, including drug mass concentration, absorption site, and the different types and concentrations of absorption inhibitors. Within the scope of experimental concentrations, three curcumin constituents were absorbed in rat small intestines through the active transport mechanism.
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spelling Absorption mechanism of three curcumin constituents through in situ intestinal perfusion methodCurcuminDemethoxycurcuminBisdethoxycurcuminIn situ intestinal perfusionAbsorption mechanismThis study aimed to investigate the absorption mechanism of three curcumin constituents in rat small intestines. Self-emulsification was used to solubilize the three curcumin constituents, and the rat in situ intestinal perfusion method was used to study factors on drug absorption, including drug mass concentration, absorption site, and the different types and concentrations of absorption inhibitors. Within the scope of experimental concentrations, three curcumin constituents were absorbed in rat small intestines through the active transport mechanism.Associação Brasileira de Divulgação Científica2017-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2017001100612Brazilian Journal of Medical and Biological Research v.50 n.11 2017reponame:Brazilian Journal of Medical and Biological Researchinstname:Associação Brasileira de Divulgação Científica (ABDC)instacron:ABDC10.1590/1414-431x20176353info:eu-repo/semantics/openAccessWang,Y.-H.Ke,X.-M.Zhang,C.-H.Yang,R.-P.eng2019-03-19T00:00:00Zoai:scielo:S0100-879X2017001100612Revistahttps://www.bjournal.org/https://old.scielo.br/oai/scielo-oai.phpbjournal@terra.com.br||bjournal@terra.com.br1414-431X0100-879Xopendoar:2019-03-19T00:00Brazilian Journal of Medical and Biological Research - Associação Brasileira de Divulgação Científica (ABDC)false
dc.title.none.fl_str_mv Absorption mechanism of three curcumin constituents through in situ intestinal perfusion method
title Absorption mechanism of three curcumin constituents through in situ intestinal perfusion method
spellingShingle Absorption mechanism of three curcumin constituents through in situ intestinal perfusion method
Wang,Y.-H.
Curcumin
Demethoxycurcumin
Bisdethoxycurcumin
In situ intestinal perfusion
Absorption mechanism
title_short Absorption mechanism of three curcumin constituents through in situ intestinal perfusion method
title_full Absorption mechanism of three curcumin constituents through in situ intestinal perfusion method
title_fullStr Absorption mechanism of three curcumin constituents through in situ intestinal perfusion method
title_full_unstemmed Absorption mechanism of three curcumin constituents through in situ intestinal perfusion method
title_sort Absorption mechanism of three curcumin constituents through in situ intestinal perfusion method
author Wang,Y.-H.
author_facet Wang,Y.-H.
Ke,X.-M.
Zhang,C.-H.
Yang,R.-P.
author_role author
author2 Ke,X.-M.
Zhang,C.-H.
Yang,R.-P.
author2_role author
author
author
dc.contributor.author.fl_str_mv Wang,Y.-H.
Ke,X.-M.
Zhang,C.-H.
Yang,R.-P.
dc.subject.por.fl_str_mv Curcumin
Demethoxycurcumin
Bisdethoxycurcumin
In situ intestinal perfusion
Absorption mechanism
topic Curcumin
Demethoxycurcumin
Bisdethoxycurcumin
In situ intestinal perfusion
Absorption mechanism
description This study aimed to investigate the absorption mechanism of three curcumin constituents in rat small intestines. Self-emulsification was used to solubilize the three curcumin constituents, and the rat in situ intestinal perfusion method was used to study factors on drug absorption, including drug mass concentration, absorption site, and the different types and concentrations of absorption inhibitors. Within the scope of experimental concentrations, three curcumin constituents were absorbed in rat small intestines through the active transport mechanism.
publishDate 2017
dc.date.none.fl_str_mv 2017-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2017001100612
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2017001100612
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/1414-431x20176353
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Associação Brasileira de Divulgação Científica
publisher.none.fl_str_mv Associação Brasileira de Divulgação Científica
dc.source.none.fl_str_mv Brazilian Journal of Medical and Biological Research v.50 n.11 2017
reponame:Brazilian Journal of Medical and Biological Research
instname:Associação Brasileira de Divulgação Científica (ABDC)
instacron:ABDC
instname_str Associação Brasileira de Divulgação Científica (ABDC)
instacron_str ABDC
institution ABDC
reponame_str Brazilian Journal of Medical and Biological Research
collection Brazilian Journal of Medical and Biological Research
repository.name.fl_str_mv Brazilian Journal of Medical and Biological Research - Associação Brasileira de Divulgação Científica (ABDC)
repository.mail.fl_str_mv bjournal@terra.com.br||bjournal@terra.com.br
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