Neurodevelopmental risk factors in schizophrenia
Autor(a) principal: | |
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Data de Publicação: | 2001 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Brazilian Journal of Medical and Biological Research |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2001000200002 |
Resumo: | The authors review environmental and neurodevelopmental risk factors for schizophrenic disorders, with emphasis on minor physical anomalies, particularly craniofacial anomalies and dermatoglyphic variations. The high prevalence of these anomalies among schizophrenic subjects supports the neurodevelopmental theory of the etiology of schizophrenia, since they suggest either genetically or epigenetically controlled faulty embryonic development of structures of ectodermal origin like brain and skin. This may disturb neurodevelopment that in turn may cause these subjects to be at increased risk for the development of schizophrenia and related disorders. The precise confirmation of this theory, at least in some cases, will provide further understanding of these illnesses, allowing easy and inexpensive identification of subjects at risk and providing guidelines for the development of new pharmacological interventions for early treatment and even for primary prevention of the illness. |
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Brazilian Journal of Medical and Biological Research |
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Neurodevelopmental risk factors in schizophreniaschizophrenianeurodevelopmental disorderrisk factorsThe authors review environmental and neurodevelopmental risk factors for schizophrenic disorders, with emphasis on minor physical anomalies, particularly craniofacial anomalies and dermatoglyphic variations. The high prevalence of these anomalies among schizophrenic subjects supports the neurodevelopmental theory of the etiology of schizophrenia, since they suggest either genetically or epigenetically controlled faulty embryonic development of structures of ectodermal origin like brain and skin. This may disturb neurodevelopment that in turn may cause these subjects to be at increased risk for the development of schizophrenia and related disorders. The precise confirmation of this theory, at least in some cases, will provide further understanding of these illnesses, allowing easy and inexpensive identification of subjects at risk and providing guidelines for the development of new pharmacological interventions for early treatment and even for primary prevention of the illness.Associação Brasileira de Divulgação Científica2001-02-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2001000200002Brazilian Journal of Medical and Biological Research v.34 n.2 2001reponame:Brazilian Journal of Medical and Biological Researchinstname:Associação Brasileira de Divulgação Científica (ABDC)instacron:ABDC10.1590/S0100-879X2001000200002info:eu-repo/semantics/openAccessLobato,M.I.Belmonte-de-Abreu,P.Knijnik,D.Teruchkin,B.Ghisolfi,E.Henriques,A.eng2001-02-09T00:00:00Zoai:scielo:S0100-879X2001000200002Revistahttps://www.bjournal.org/https://old.scielo.br/oai/scielo-oai.phpbjournal@terra.com.br||bjournal@terra.com.br1414-431X0100-879Xopendoar:2001-02-09T00:00Brazilian Journal of Medical and Biological Research - Associação Brasileira de Divulgação Científica (ABDC)false |
dc.title.none.fl_str_mv |
Neurodevelopmental risk factors in schizophrenia |
title |
Neurodevelopmental risk factors in schizophrenia |
spellingShingle |
Neurodevelopmental risk factors in schizophrenia Lobato,M.I. schizophrenia neurodevelopmental disorder risk factors |
title_short |
Neurodevelopmental risk factors in schizophrenia |
title_full |
Neurodevelopmental risk factors in schizophrenia |
title_fullStr |
Neurodevelopmental risk factors in schizophrenia |
title_full_unstemmed |
Neurodevelopmental risk factors in schizophrenia |
title_sort |
Neurodevelopmental risk factors in schizophrenia |
author |
Lobato,M.I. |
author_facet |
Lobato,M.I. Belmonte-de-Abreu,P. Knijnik,D. Teruchkin,B. Ghisolfi,E. Henriques,A. |
author_role |
author |
author2 |
Belmonte-de-Abreu,P. Knijnik,D. Teruchkin,B. Ghisolfi,E. Henriques,A. |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Lobato,M.I. Belmonte-de-Abreu,P. Knijnik,D. Teruchkin,B. Ghisolfi,E. Henriques,A. |
dc.subject.por.fl_str_mv |
schizophrenia neurodevelopmental disorder risk factors |
topic |
schizophrenia neurodevelopmental disorder risk factors |
description |
The authors review environmental and neurodevelopmental risk factors for schizophrenic disorders, with emphasis on minor physical anomalies, particularly craniofacial anomalies and dermatoglyphic variations. The high prevalence of these anomalies among schizophrenic subjects supports the neurodevelopmental theory of the etiology of schizophrenia, since they suggest either genetically or epigenetically controlled faulty embryonic development of structures of ectodermal origin like brain and skin. This may disturb neurodevelopment that in turn may cause these subjects to be at increased risk for the development of schizophrenia and related disorders. The precise confirmation of this theory, at least in some cases, will provide further understanding of these illnesses, allowing easy and inexpensive identification of subjects at risk and providing guidelines for the development of new pharmacological interventions for early treatment and even for primary prevention of the illness. |
publishDate |
2001 |
dc.date.none.fl_str_mv |
2001-02-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2001000200002 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2001000200002 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0100-879X2001000200002 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Associação Brasileira de Divulgação Científica |
publisher.none.fl_str_mv |
Associação Brasileira de Divulgação Científica |
dc.source.none.fl_str_mv |
Brazilian Journal of Medical and Biological Research v.34 n.2 2001 reponame:Brazilian Journal of Medical and Biological Research instname:Associação Brasileira de Divulgação Científica (ABDC) instacron:ABDC |
instname_str |
Associação Brasileira de Divulgação Científica (ABDC) |
instacron_str |
ABDC |
institution |
ABDC |
reponame_str |
Brazilian Journal of Medical and Biological Research |
collection |
Brazilian Journal of Medical and Biological Research |
repository.name.fl_str_mv |
Brazilian Journal of Medical and Biological Research - Associação Brasileira de Divulgação Científica (ABDC) |
repository.mail.fl_str_mv |
bjournal@terra.com.br||bjournal@terra.com.br |
_version_ |
1754302930899435520 |