Heart failure with preserved ejection fraction: an update on pathophysiology, diagnosis, treatment, and prognosis
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Brazilian Journal of Medical and Biological Research |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2020000700301 |
Resumo: | Heart failure (HF) with preserved ejection fraction (HFpEF) is a clinical syndrome in which patients have symptoms and signs of HF with normal or near-normal left ventricular ejection fraction (LVEF ≥50%). Roughly half of all patients with HF worldwide have an LVEF ≥50% and nearly half have an LVEF <50%. Thanks to the increased scientific attention about the condition and improved characterization and diagnostic tools, the incidence of HF with reduced ejection fraction (HFrEF) dropped while that of HFpEF has increased by 45%. HFpEF has no single guideline for diagnosis or treatment, the patient population is heterogeneously and inconsistently described, and longitudinal studies are lacking. To better understand and overcome the disease, in this review, we updated the latest knowledge of HFpEF pathophysiology, introduced the existing promising diagnostic methods and treatments, and summarized its prognosis by reviewing the most recent cohort studies. |
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Heart failure with preserved ejection fraction: an update on pathophysiology, diagnosis, treatment, and prognosisHeart failure with preserved ejection fractionHeart failure with reduced ejection fractionHeart failureHFpEFHFrEFPathophysiologyHeart failure (HF) with preserved ejection fraction (HFpEF) is a clinical syndrome in which patients have symptoms and signs of HF with normal or near-normal left ventricular ejection fraction (LVEF ≥50%). Roughly half of all patients with HF worldwide have an LVEF ≥50% and nearly half have an LVEF <50%. Thanks to the increased scientific attention about the condition and improved characterization and diagnostic tools, the incidence of HF with reduced ejection fraction (HFrEF) dropped while that of HFpEF has increased by 45%. HFpEF has no single guideline for diagnosis or treatment, the patient population is heterogeneously and inconsistently described, and longitudinal studies are lacking. To better understand and overcome the disease, in this review, we updated the latest knowledge of HFpEF pathophysiology, introduced the existing promising diagnostic methods and treatments, and summarized its prognosis by reviewing the most recent cohort studies.Associação Brasileira de Divulgação Científica2020-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2020000700301Brazilian Journal of Medical and Biological Research v.53 n.7 2020reponame:Brazilian Journal of Medical and Biological Researchinstname:Associação Brasileira de Divulgação Científica (ABDC)instacron:ABDC10.1590/1414-431x20209646info:eu-repo/semantics/openAccessMa,ChaoLuo,HuanFan,LeiLiu,XiaoyanGao,Chengshaneng2021-02-24T00:00:00Zoai:scielo:S0100-879X2020000700301Revistahttps://www.bjournal.org/https://old.scielo.br/oai/scielo-oai.phpbjournal@terra.com.br||bjournal@terra.com.br1414-431X0100-879Xopendoar:2021-02-24T00:00Brazilian Journal of Medical and Biological Research - Associação Brasileira de Divulgação Científica (ABDC)false |
dc.title.none.fl_str_mv |
Heart failure with preserved ejection fraction: an update on pathophysiology, diagnosis, treatment, and prognosis |
title |
Heart failure with preserved ejection fraction: an update on pathophysiology, diagnosis, treatment, and prognosis |
spellingShingle |
Heart failure with preserved ejection fraction: an update on pathophysiology, diagnosis, treatment, and prognosis Ma,Chao Heart failure with preserved ejection fraction Heart failure with reduced ejection fraction Heart failure HFpEF HFrEF Pathophysiology |
title_short |
Heart failure with preserved ejection fraction: an update on pathophysiology, diagnosis, treatment, and prognosis |
title_full |
Heart failure with preserved ejection fraction: an update on pathophysiology, diagnosis, treatment, and prognosis |
title_fullStr |
Heart failure with preserved ejection fraction: an update on pathophysiology, diagnosis, treatment, and prognosis |
title_full_unstemmed |
Heart failure with preserved ejection fraction: an update on pathophysiology, diagnosis, treatment, and prognosis |
title_sort |
Heart failure with preserved ejection fraction: an update on pathophysiology, diagnosis, treatment, and prognosis |
author |
Ma,Chao |
author_facet |
Ma,Chao Luo,Huan Fan,Lei Liu,Xiaoyan Gao,Chengshan |
author_role |
author |
author2 |
Luo,Huan Fan,Lei Liu,Xiaoyan Gao,Chengshan |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Ma,Chao Luo,Huan Fan,Lei Liu,Xiaoyan Gao,Chengshan |
dc.subject.por.fl_str_mv |
Heart failure with preserved ejection fraction Heart failure with reduced ejection fraction Heart failure HFpEF HFrEF Pathophysiology |
topic |
Heart failure with preserved ejection fraction Heart failure with reduced ejection fraction Heart failure HFpEF HFrEF Pathophysiology |
description |
Heart failure (HF) with preserved ejection fraction (HFpEF) is a clinical syndrome in which patients have symptoms and signs of HF with normal or near-normal left ventricular ejection fraction (LVEF ≥50%). Roughly half of all patients with HF worldwide have an LVEF ≥50% and nearly half have an LVEF <50%. Thanks to the increased scientific attention about the condition and improved characterization and diagnostic tools, the incidence of HF with reduced ejection fraction (HFrEF) dropped while that of HFpEF has increased by 45%. HFpEF has no single guideline for diagnosis or treatment, the patient population is heterogeneously and inconsistently described, and longitudinal studies are lacking. To better understand and overcome the disease, in this review, we updated the latest knowledge of HFpEF pathophysiology, introduced the existing promising diagnostic methods and treatments, and summarized its prognosis by reviewing the most recent cohort studies. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2020000700301 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2020000700301 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/1414-431x20209646 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Associação Brasileira de Divulgação Científica |
publisher.none.fl_str_mv |
Associação Brasileira de Divulgação Científica |
dc.source.none.fl_str_mv |
Brazilian Journal of Medical and Biological Research v.53 n.7 2020 reponame:Brazilian Journal of Medical and Biological Research instname:Associação Brasileira de Divulgação Científica (ABDC) instacron:ABDC |
instname_str |
Associação Brasileira de Divulgação Científica (ABDC) |
instacron_str |
ABDC |
institution |
ABDC |
reponame_str |
Brazilian Journal of Medical and Biological Research |
collection |
Brazilian Journal of Medical and Biological Research |
repository.name.fl_str_mv |
Brazilian Journal of Medical and Biological Research - Associação Brasileira de Divulgação Científica (ABDC) |
repository.mail.fl_str_mv |
bjournal@terra.com.br||bjournal@terra.com.br |
_version_ |
1754302947656728576 |