Prostanoids modulate inflammation and alloimmune responses during graft rejection

Detalhes bibliográficos
Autor(a) principal: Rocha,P.N.
Data de Publicação: 2005
Outros Autores: Carvalho,E.M.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Brazilian Journal of Medical and Biological Research
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2005001200004
Resumo: Acute rejection of a transplanted organ is characterized by intense inflammation within the graft. Yet, for many years transplant researchers have overlooked the role of classic mediators of inflammation such as prostaglandins and thromboxane (prostanoids) in alloimmune responses. It has been demonstrated that local production of prostanoids within the allograft is increased during an episode of acute rejection and that these molecules are able to interfere with graft function by modulating vascular tone, capillary permeability, and platelet aggregation. Experimental data also suggest that prostanoids may participate in alloimmune responses by directly modulating T lymphocyte and antigen-presenting cell function. In the present paper, we provide a brief overview of the alloimmune response, of prostanoid biology, and discuss the available evidence for the role of prostaglandin E2 and thromboxane A2 in graft rejection.
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spelling Prostanoids modulate inflammation and alloimmune responses during graft rejectionThromboxaneProstaglandinsTransplantationInflammationRejectionCorticosteroidsAcute rejection of a transplanted organ is characterized by intense inflammation within the graft. Yet, for many years transplant researchers have overlooked the role of classic mediators of inflammation such as prostaglandins and thromboxane (prostanoids) in alloimmune responses. It has been demonstrated that local production of prostanoids within the allograft is increased during an episode of acute rejection and that these molecules are able to interfere with graft function by modulating vascular tone, capillary permeability, and platelet aggregation. Experimental data also suggest that prostanoids may participate in alloimmune responses by directly modulating T lymphocyte and antigen-presenting cell function. In the present paper, we provide a brief overview of the alloimmune response, of prostanoid biology, and discuss the available evidence for the role of prostaglandin E2 and thromboxane A2 in graft rejection.Associação Brasileira de Divulgação Científica2005-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2005001200004Brazilian Journal of Medical and Biological Research v.38 n.12 2005reponame:Brazilian Journal of Medical and Biological Researchinstname:Associação Brasileira de Divulgação Científica (ABDC)instacron:ABDC10.1590/S0100-879X2005001200004info:eu-repo/semantics/openAccessRocha,P.N.Carvalho,E.M.eng2005-11-09T00:00:00Zoai:scielo:S0100-879X2005001200004Revistahttps://www.bjournal.org/https://old.scielo.br/oai/scielo-oai.phpbjournal@terra.com.br||bjournal@terra.com.br1414-431X0100-879Xopendoar:2005-11-09T00:00Brazilian Journal of Medical and Biological Research - Associação Brasileira de Divulgação Científica (ABDC)false
dc.title.none.fl_str_mv Prostanoids modulate inflammation and alloimmune responses during graft rejection
title Prostanoids modulate inflammation and alloimmune responses during graft rejection
spellingShingle Prostanoids modulate inflammation and alloimmune responses during graft rejection
Rocha,P.N.
Thromboxane
Prostaglandins
Transplantation
Inflammation
Rejection
Corticosteroids
title_short Prostanoids modulate inflammation and alloimmune responses during graft rejection
title_full Prostanoids modulate inflammation and alloimmune responses during graft rejection
title_fullStr Prostanoids modulate inflammation and alloimmune responses during graft rejection
title_full_unstemmed Prostanoids modulate inflammation and alloimmune responses during graft rejection
title_sort Prostanoids modulate inflammation and alloimmune responses during graft rejection
author Rocha,P.N.
author_facet Rocha,P.N.
Carvalho,E.M.
author_role author
author2 Carvalho,E.M.
author2_role author
dc.contributor.author.fl_str_mv Rocha,P.N.
Carvalho,E.M.
dc.subject.por.fl_str_mv Thromboxane
Prostaglandins
Transplantation
Inflammation
Rejection
Corticosteroids
topic Thromboxane
Prostaglandins
Transplantation
Inflammation
Rejection
Corticosteroids
description Acute rejection of a transplanted organ is characterized by intense inflammation within the graft. Yet, for many years transplant researchers have overlooked the role of classic mediators of inflammation such as prostaglandins and thromboxane (prostanoids) in alloimmune responses. It has been demonstrated that local production of prostanoids within the allograft is increased during an episode of acute rejection and that these molecules are able to interfere with graft function by modulating vascular tone, capillary permeability, and platelet aggregation. Experimental data also suggest that prostanoids may participate in alloimmune responses by directly modulating T lymphocyte and antigen-presenting cell function. In the present paper, we provide a brief overview of the alloimmune response, of prostanoid biology, and discuss the available evidence for the role of prostaglandin E2 and thromboxane A2 in graft rejection.
publishDate 2005
dc.date.none.fl_str_mv 2005-12-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2005001200004
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2005001200004
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0100-879X2005001200004
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Associação Brasileira de Divulgação Científica
publisher.none.fl_str_mv Associação Brasileira de Divulgação Científica
dc.source.none.fl_str_mv Brazilian Journal of Medical and Biological Research v.38 n.12 2005
reponame:Brazilian Journal of Medical and Biological Research
instname:Associação Brasileira de Divulgação Científica (ABDC)
instacron:ABDC
instname_str Associação Brasileira de Divulgação Científica (ABDC)
instacron_str ABDC
institution ABDC
reponame_str Brazilian Journal of Medical and Biological Research
collection Brazilian Journal of Medical and Biological Research
repository.name.fl_str_mv Brazilian Journal of Medical and Biological Research - Associação Brasileira de Divulgação Científica (ABDC)
repository.mail.fl_str_mv bjournal@terra.com.br||bjournal@terra.com.br
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