A mathematical model describing the kinetic of cationic liposome production from dried lipid films adsorbed in a multitubular system

Bibliographic Details
Main Author: Torre,L. G.
Publication Date: 2007
Other Authors: Carneiro,A. L., Rosada,R. S., Silva,C. L., Santana,M. H. A.
Format: Article
Language: eng
Source: Brazilian Journal of Chemical Engineering
Download full: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-66322007000400002
Summary: Cationic liposomes are an alternative to DNA non-viral carrier in gene therapy, promoting higher efficiency for transport and delivery into the cells. Liposome production large scale is still a challenge. Among many processes, from dried film adsorbed inside multitubular system promising due its operational simplicity. this field, engineering contributions scarce no mathematical treatment literature describing type of process available. formulation proposed describe kinetic considering wetting disintegration lipid followed by lipids aggregation bilayers generating liposomes. model has fitted experimental data mass thickness, being useful predictions scaling up as well contributing development pharmaceutical products.
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spelling A mathematical model describing the kinetic of cationic liposome production from dried lipid films adsorbed in a multitubular systemLiposomesScale-upMathematical modelingCationic liposomes are an alternative to DNA non-viral carrier in gene therapy, promoting higher efficiency for transport and delivery into the cells. Liposome production large scale is still a challenge. Among many processes, from dried film adsorbed inside multitubular system promising due its operational simplicity. this field, engineering contributions scarce no mathematical treatment literature describing type of process available. formulation proposed describe kinetic considering wetting disintegration lipid followed by lipids aggregation bilayers generating liposomes. model has fitted experimental data mass thickness, being useful predictions scaling up as well contributing development pharmaceutical products.Brazilian Society of Chemical Engineering2007-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-66322007000400002Brazilian Journal of Chemical Engineering v.24 n.4 2007reponame:Brazilian Journal of Chemical Engineeringinstname:Associação Brasileira de Engenharia Química (ABEQ)instacron:ABEQ10.1590/S0104-66322007000400002info:eu-repo/semantics/openAccessTorre,L. G.Carneiro,A. L.Rosada,R. S.Silva,C. L.Santana,M. H. A.eng2008-02-11T00:00:00Zoai:scielo:S0104-66322007000400002Revistahttps://www.scielo.br/j/bjce/https://old.scielo.br/oai/scielo-oai.phprgiudici@usp.br||rgiudici@usp.br1678-43830104-6632opendoar:2008-02-11T00:00Brazilian Journal of Chemical Engineering - Associação Brasileira de Engenharia Química (ABEQ)false
dc.title.none.fl_str_mv A mathematical model describing the kinetic of cationic liposome production from dried lipid films adsorbed in a multitubular system
title A mathematical model describing the kinetic of cationic liposome production from dried lipid films adsorbed in a multitubular system
spellingShingle A mathematical model describing the kinetic of cationic liposome production from dried lipid films adsorbed in a multitubular system
Torre,L. G.
Liposomes
Scale-up
Mathematical modeling
title_short A mathematical model describing the kinetic of cationic liposome production from dried lipid films adsorbed in a multitubular system
title_full A mathematical model describing the kinetic of cationic liposome production from dried lipid films adsorbed in a multitubular system
title_fullStr A mathematical model describing the kinetic of cationic liposome production from dried lipid films adsorbed in a multitubular system
title_full_unstemmed A mathematical model describing the kinetic of cationic liposome production from dried lipid films adsorbed in a multitubular system
title_sort A mathematical model describing the kinetic of cationic liposome production from dried lipid films adsorbed in a multitubular system
author Torre,L. G.
author_facet Torre,L. G.
Carneiro,A. L.
Rosada,R. S.
Silva,C. L.
Santana,M. H. A.
author_role author
author2 Carneiro,A. L.
Rosada,R. S.
Silva,C. L.
Santana,M. H. A.
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Torre,L. G.
Carneiro,A. L.
Rosada,R. S.
Silva,C. L.
Santana,M. H. A.
dc.subject.por.fl_str_mv Liposomes
Scale-up
Mathematical modeling
topic Liposomes
Scale-up
Mathematical modeling
description Cationic liposomes are an alternative to DNA non-viral carrier in gene therapy, promoting higher efficiency for transport and delivery into the cells. Liposome production large scale is still a challenge. Among many processes, from dried film adsorbed inside multitubular system promising due its operational simplicity. this field, engineering contributions scarce no mathematical treatment literature describing type of process available. formulation proposed describe kinetic considering wetting disintegration lipid followed by lipids aggregation bilayers generating liposomes. model has fitted experimental data mass thickness, being useful predictions scaling up as well contributing development pharmaceutical products.
publishDate 2007
dc.date.none.fl_str_mv 2007-12-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-66322007000400002
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-66322007000400002
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0104-66322007000400002
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Brazilian Society of Chemical Engineering
publisher.none.fl_str_mv Brazilian Society of Chemical Engineering
dc.source.none.fl_str_mv Brazilian Journal of Chemical Engineering v.24 n.4 2007
reponame:Brazilian Journal of Chemical Engineering
instname:Associação Brasileira de Engenharia Química (ABEQ)
instacron:ABEQ
instname_str Associação Brasileira de Engenharia Química (ABEQ)
instacron_str ABEQ
institution ABEQ
reponame_str Brazilian Journal of Chemical Engineering
collection Brazilian Journal of Chemical Engineering
repository.name.fl_str_mv Brazilian Journal of Chemical Engineering - Associação Brasileira de Engenharia Química (ABEQ)
repository.mail.fl_str_mv rgiudici@usp.br||rgiudici@usp.br
_version_ 1754213172330364928

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