Monitoring imatinib plasma concentrations in chronic myeloid leukemia
Autor(a) principal: | |
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Data de Publicação: | 2011 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Revista brasileira de hematologia e hemoterapia (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-84842011000400016 |
Resumo: | Imatinib has proved to be effective in the treatment of chronic myeloid leukemia, but plasma levels above 1,000 ng/mL must be achieved to optimize activity. Therapeutic drug monitoring of imatinib is useful for patients that do not present clinical response. There are several analytical methods to measure imatinib in biosamples, which are mainly based on liquid chromatography with mass spectrometric or diode array spectrophotometric detection. The former is preferred due to its lower cost and wider availability. The present manuscript presents a review of the clinical and analytical aspects of the therapeutic drug monitoring of imatinib in the treatment of chronic myeloid leukemia. The review includes references published over the last 10 years. There is evidence that the monitoring of plasmatic levels of imatinib is an useful alternative, especially considering the wide pharmacokinetic variability of this drug. |
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Monitoring imatinib plasma concentrations in chronic myeloid leukemiaLeukemia, myelogenous, chronic, BCR-ABL Positive/drug therapyAntineoplastic agents/therapeutic usePiperazines/pharmacokineticsPyrimidines/pharmacokineticsDrug monitoringChromatographyCytochrome P-450 CYP3A/metabolismAlgorithmsImatinib has proved to be effective in the treatment of chronic myeloid leukemia, but plasma levels above 1,000 ng/mL must be achieved to optimize activity. Therapeutic drug monitoring of imatinib is useful for patients that do not present clinical response. There are several analytical methods to measure imatinib in biosamples, which are mainly based on liquid chromatography with mass spectrometric or diode array spectrophotometric detection. The former is preferred due to its lower cost and wider availability. The present manuscript presents a review of the clinical and analytical aspects of the therapeutic drug monitoring of imatinib in the treatment of chronic myeloid leukemia. The review includes references published over the last 10 years. There is evidence that the monitoring of plasmatic levels of imatinib is an useful alternative, especially considering the wide pharmacokinetic variability of this drug.Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular2011-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-84842011000400016Revista Brasileira de Hematologia e Hemoterapia v.33 n.4 2011reponame:Revista brasileira de hematologia e hemoterapia (Online)instname:Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular (ABHHTC)instacron:ABHHTC10.5581/1516-8484.20110081info:eu-repo/semantics/openAccessMartins,Darlize HübnerWagner,Sandrine ComparsiSantos,Tamyris Vianna dosLizot,Lilian de Lima FeltracoAntunes,Marina VenzonCapra,MarceloLinden,Rafaeleng2011-09-20T00:00:00Zoai:scielo:S1516-84842011000400016Revistahttp://www.rbhh.org/pt/archivo/https://old.scielo.br/oai/scielo-oai.phpsbhh@terra.com.br||secretaria@rbhh.org1806-08701516-8484opendoar:2011-09-20T00:00Revista brasileira de hematologia e hemoterapia (Online) - Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular (ABHHTC)false |
dc.title.none.fl_str_mv |
Monitoring imatinib plasma concentrations in chronic myeloid leukemia |
title |
Monitoring imatinib plasma concentrations in chronic myeloid leukemia |
spellingShingle |
Monitoring imatinib plasma concentrations in chronic myeloid leukemia Martins,Darlize Hübner Leukemia, myelogenous, chronic, BCR-ABL Positive/drug therapy Antineoplastic agents/therapeutic use Piperazines/pharmacokinetics Pyrimidines/pharmacokinetics Drug monitoring Chromatography Cytochrome P-450 CYP3A/metabolism Algorithms |
title_short |
Monitoring imatinib plasma concentrations in chronic myeloid leukemia |
title_full |
Monitoring imatinib plasma concentrations in chronic myeloid leukemia |
title_fullStr |
Monitoring imatinib plasma concentrations in chronic myeloid leukemia |
title_full_unstemmed |
Monitoring imatinib plasma concentrations in chronic myeloid leukemia |
title_sort |
Monitoring imatinib plasma concentrations in chronic myeloid leukemia |
author |
Martins,Darlize Hübner |
author_facet |
Martins,Darlize Hübner Wagner,Sandrine Comparsi Santos,Tamyris Vianna dos Lizot,Lilian de Lima Feltraco Antunes,Marina Venzon Capra,Marcelo Linden,Rafael |
author_role |
author |
author2 |
Wagner,Sandrine Comparsi Santos,Tamyris Vianna dos Lizot,Lilian de Lima Feltraco Antunes,Marina Venzon Capra,Marcelo Linden,Rafael |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Martins,Darlize Hübner Wagner,Sandrine Comparsi Santos,Tamyris Vianna dos Lizot,Lilian de Lima Feltraco Antunes,Marina Venzon Capra,Marcelo Linden,Rafael |
dc.subject.por.fl_str_mv |
Leukemia, myelogenous, chronic, BCR-ABL Positive/drug therapy Antineoplastic agents/therapeutic use Piperazines/pharmacokinetics Pyrimidines/pharmacokinetics Drug monitoring Chromatography Cytochrome P-450 CYP3A/metabolism Algorithms |
topic |
Leukemia, myelogenous, chronic, BCR-ABL Positive/drug therapy Antineoplastic agents/therapeutic use Piperazines/pharmacokinetics Pyrimidines/pharmacokinetics Drug monitoring Chromatography Cytochrome P-450 CYP3A/metabolism Algorithms |
description |
Imatinib has proved to be effective in the treatment of chronic myeloid leukemia, but plasma levels above 1,000 ng/mL must be achieved to optimize activity. Therapeutic drug monitoring of imatinib is useful for patients that do not present clinical response. There are several analytical methods to measure imatinib in biosamples, which are mainly based on liquid chromatography with mass spectrometric or diode array spectrophotometric detection. The former is preferred due to its lower cost and wider availability. The present manuscript presents a review of the clinical and analytical aspects of the therapeutic drug monitoring of imatinib in the treatment of chronic myeloid leukemia. The review includes references published over the last 10 years. There is evidence that the monitoring of plasmatic levels of imatinib is an useful alternative, especially considering the wide pharmacokinetic variability of this drug. |
publishDate |
2011 |
dc.date.none.fl_str_mv |
2011-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-84842011000400016 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-84842011000400016 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.5581/1516-8484.20110081 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular |
publisher.none.fl_str_mv |
Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular |
dc.source.none.fl_str_mv |
Revista Brasileira de Hematologia e Hemoterapia v.33 n.4 2011 reponame:Revista brasileira de hematologia e hemoterapia (Online) instname:Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular (ABHHTC) instacron:ABHHTC |
instname_str |
Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular (ABHHTC) |
instacron_str |
ABHHTC |
institution |
ABHHTC |
reponame_str |
Revista brasileira de hematologia e hemoterapia (Online) |
collection |
Revista brasileira de hematologia e hemoterapia (Online) |
repository.name.fl_str_mv |
Revista brasileira de hematologia e hemoterapia (Online) - Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular (ABHHTC) |
repository.mail.fl_str_mv |
sbhh@terra.com.br||secretaria@rbhh.org |
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1754213111495131136 |