Oral cancer after prolonged immunosuppression for multiorgan chronic graft-versus-host disease

• Autor(a) principal: Araujo,Renata Lins Fuentes de
• Data de Publicação: 2014
• Outros Autores: Lyko,Karine de Fatima, Funke,Vaneuza Araujo Moreira, Torres-Pereira,Cassius Carvalho
• Tipo de documento: Relatório
• Idioma: eng
• Título da fonte: Revista brasileira de hematologia e hemoterapia (Online)
• Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-84842014000100065
• topic: Mouth neoplasms; Bone marrow transplantation; Leukemia; Myeloid; Graft-versus-host disease

Long-term survivors of hematopoietic stem cell transplantation are recognized as a risk group for malignization. Malignant oral neoplasms are increasingly being reported in the literature as a consequence of lesions of chronic graft-versus-host disease, and prolonged multidrug treatment to control its manifestations. This report describes a 43-year-old patient who, after allogeneic bone marrow transplantation, developed an oral squamous cell carcinoma secondary to the use of azathioprine, cyclosporine, prednisone, and tacrolimus, associated with multiorgan chronic graft-versus-host disease involving the oral mucosa, skin, eyes, and liver. This report aims to discuss the possible role of immunosuppressant therapy for chronic graft-versus-host disease on the development of oral squamous cell carcinoma, and the relevance of a close oral follow-up of patients to detect dysplastic or malignant alterations at an early stage.