Ibuprofen Release from Hydrotalcite-like Materials Filled into Chitosan/Alginate Composites as Promising Reabsorbable Membranes

Detalhes bibliográficos
Autor(a) principal: Machado,Monielly Viomar
Data de Publicação: 2021
Outros Autores: Jaerger,Silvia, Zatta,Leandro, Danczuk,Marins, Marangoni,Rafael
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Materials research (São Carlos. Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-14392021000800213
Resumo: Abstract Hydrotalcite-type materials, or layered double hydroxide (LDH), are very promising in applying slow-release drug systems through ion exchange and delamination characteristics at acidic pH. In this paper, Zn/Al LDHs in 2:1 and 3:1 molar ratios intercalated with the drug ibuprofen (IBU) were added to chitosan/alginate membranes. In the release tests, an increase in the solubility of the drug in the membranes could be observed, and the percentage of drug release is lower than the percentage of drug release in the free samples. The following release percentages were obtained: 15.48% and 17.5% of the drug in water, and 23.22% and 26.25% of the drug in PBS buffer solution, respectively, for membrane samples containing Zn2Al-IBU and Zn3Al-IBU LDHs. Thus, the synthesized hybrid membranes (chitosan/alginate-LDH-IBU) are promising in the application as resorbable membranes for bone grafting with drug release.
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spelling Ibuprofen Release from Hydrotalcite-like Materials Filled into Chitosan/Alginate Composites as Promising Reabsorbable Membraneslayered double hydroxidealginatechitosandrug releaseAbstract Hydrotalcite-type materials, or layered double hydroxide (LDH), are very promising in applying slow-release drug systems through ion exchange and delamination characteristics at acidic pH. In this paper, Zn/Al LDHs in 2:1 and 3:1 molar ratios intercalated with the drug ibuprofen (IBU) were added to chitosan/alginate membranes. In the release tests, an increase in the solubility of the drug in the membranes could be observed, and the percentage of drug release is lower than the percentage of drug release in the free samples. The following release percentages were obtained: 15.48% and 17.5% of the drug in water, and 23.22% and 26.25% of the drug in PBS buffer solution, respectively, for membrane samples containing Zn2Al-IBU and Zn3Al-IBU LDHs. Thus, the synthesized hybrid membranes (chitosan/alginate-LDH-IBU) are promising in the application as resorbable membranes for bone grafting with drug release.ABM, ABC, ABPol2021-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-14392021000800213Materials Research v.24 suppl.2 2021reponame:Materials research (São Carlos. Online)instname:Universidade Federal de São Carlos (UFSCAR)instacron:ABM ABC ABPOL10.1590/1980-5373-mr-2021-0312info:eu-repo/semantics/openAccessMachado,Monielly ViomarJaerger,SilviaZatta,LeandroDanczuk,MarinsMarangoni,Rafaeleng2022-01-26T00:00:00Zoai:scielo:S1516-14392021000800213Revistahttp://www.scielo.br/mrPUBhttps://old.scielo.br/oai/scielo-oai.phpdedz@power.ufscar.br1980-53731516-1439opendoar:2022-01-26T00:00Materials research (São Carlos. Online) - Universidade Federal de São Carlos (UFSCAR)false
dc.title.none.fl_str_mv Ibuprofen Release from Hydrotalcite-like Materials Filled into Chitosan/Alginate Composites as Promising Reabsorbable Membranes
title Ibuprofen Release from Hydrotalcite-like Materials Filled into Chitosan/Alginate Composites as Promising Reabsorbable Membranes
spellingShingle Ibuprofen Release from Hydrotalcite-like Materials Filled into Chitosan/Alginate Composites as Promising Reabsorbable Membranes
Machado,Monielly Viomar
layered double hydroxide
alginate
chitosan
drug release
title_short Ibuprofen Release from Hydrotalcite-like Materials Filled into Chitosan/Alginate Composites as Promising Reabsorbable Membranes
title_full Ibuprofen Release from Hydrotalcite-like Materials Filled into Chitosan/Alginate Composites as Promising Reabsorbable Membranes
title_fullStr Ibuprofen Release from Hydrotalcite-like Materials Filled into Chitosan/Alginate Composites as Promising Reabsorbable Membranes
title_full_unstemmed Ibuprofen Release from Hydrotalcite-like Materials Filled into Chitosan/Alginate Composites as Promising Reabsorbable Membranes
title_sort Ibuprofen Release from Hydrotalcite-like Materials Filled into Chitosan/Alginate Composites as Promising Reabsorbable Membranes
author Machado,Monielly Viomar
author_facet Machado,Monielly Viomar
Jaerger,Silvia
Zatta,Leandro
Danczuk,Marins
Marangoni,Rafael
author_role author
author2 Jaerger,Silvia
Zatta,Leandro
Danczuk,Marins
Marangoni,Rafael
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Machado,Monielly Viomar
Jaerger,Silvia
Zatta,Leandro
Danczuk,Marins
Marangoni,Rafael
dc.subject.por.fl_str_mv layered double hydroxide
alginate
chitosan
drug release
topic layered double hydroxide
alginate
chitosan
drug release
description Abstract Hydrotalcite-type materials, or layered double hydroxide (LDH), are very promising in applying slow-release drug systems through ion exchange and delamination characteristics at acidic pH. In this paper, Zn/Al LDHs in 2:1 and 3:1 molar ratios intercalated with the drug ibuprofen (IBU) were added to chitosan/alginate membranes. In the release tests, an increase in the solubility of the drug in the membranes could be observed, and the percentage of drug release is lower than the percentage of drug release in the free samples. The following release percentages were obtained: 15.48% and 17.5% of the drug in water, and 23.22% and 26.25% of the drug in PBS buffer solution, respectively, for membrane samples containing Zn2Al-IBU and Zn3Al-IBU LDHs. Thus, the synthesized hybrid membranes (chitosan/alginate-LDH-IBU) are promising in the application as resorbable membranes for bone grafting with drug release.
publishDate 2021
dc.date.none.fl_str_mv 2021-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-14392021000800213
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-14392021000800213
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/1980-5373-mr-2021-0312
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv ABM, ABC, ABPol
publisher.none.fl_str_mv ABM, ABC, ABPol
dc.source.none.fl_str_mv Materials Research v.24 suppl.2 2021
reponame:Materials research (São Carlos. Online)
instname:Universidade Federal de São Carlos (UFSCAR)
instacron:ABM ABC ABPOL
instname_str Universidade Federal de São Carlos (UFSCAR)
instacron_str ABM ABC ABPOL
institution ABM ABC ABPOL
reponame_str Materials research (São Carlos. Online)
collection Materials research (São Carlos. Online)
repository.name.fl_str_mv Materials research (São Carlos. Online) - Universidade Federal de São Carlos (UFSCAR)
repository.mail.fl_str_mv dedz@power.ufscar.br
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