Evaluation of the biocompatibility of a new biomembrane
Autor(a) principal: | |
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Data de Publicação: | 2004 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Materials research (São Carlos. Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-14392004000200010 |
Resumo: | Biocompatibility has been considered one of the most important items to validate a biomaterial for its application in human organisms. The present work evaluates the biocompatibility of a new biomembrane using in vivo assay in different animal species. The experiments to evaluate the cellular reaction were carried out through the implantation of the material into the subcutaneous tissue of animals and the results showed a good reaction of the host tissue without any signal of fibrosis or rejection. The cell adhesion experiments were done by means of the measure of the DNA content on the material surface after its implantation into the subcutaneous tissue of animals and the results showed a growing number of DNA that was proportional to the time of implantation. The healing process was evaluated using a dermal ulcer model and the results showed a good tissue repair resembling a physiologic process. The overall results presented here lead to the conclusion that this new biomembrane is a biocompatible material but more research must be done, as it is a new material desired for medical use. |
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Evaluation of the biocompatibility of a new biomembraneBiomaterialbiomembranebiocompatibilityBiocompatibility has been considered one of the most important items to validate a biomaterial for its application in human organisms. The present work evaluates the biocompatibility of a new biomembrane using in vivo assay in different animal species. The experiments to evaluate the cellular reaction were carried out through the implantation of the material into the subcutaneous tissue of animals and the results showed a good reaction of the host tissue without any signal of fibrosis or rejection. The cell adhesion experiments were done by means of the measure of the DNA content on the material surface after its implantation into the subcutaneous tissue of animals and the results showed a growing number of DNA that was proportional to the time of implantation. The healing process was evaluated using a dermal ulcer model and the results showed a good tissue repair resembling a physiologic process. The overall results presented here lead to the conclusion that this new biomembrane is a biocompatible material but more research must be done, as it is a new material desired for medical use.ABM, ABC, ABPol2004-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-14392004000200010Materials Research v.7 n.2 2004reponame:Materials research (São Carlos. Online)instname:Universidade Federal de São Carlos (UFSCAR)instacron:ABM ABC ABPOL10.1590/S1516-14392004000200010info:eu-repo/semantics/openAccessMrue,FatimaNetto,Joaquim CoutinhoCeneviva,ReginaldoLachat,João JoséThomazini,José AntônioTambelini,Heldereng2004-06-29T00:00:00Zoai:scielo:S1516-14392004000200010Revistahttp://www.scielo.br/mrPUBhttps://old.scielo.br/oai/scielo-oai.phpdedz@power.ufscar.br1980-53731516-1439opendoar:2004-06-29T00:00Materials research (São Carlos. Online) - Universidade Federal de São Carlos (UFSCAR)false |
dc.title.none.fl_str_mv |
Evaluation of the biocompatibility of a new biomembrane |
title |
Evaluation of the biocompatibility of a new biomembrane |
spellingShingle |
Evaluation of the biocompatibility of a new biomembrane Mrue,Fatima Biomaterial biomembrane biocompatibility |
title_short |
Evaluation of the biocompatibility of a new biomembrane |
title_full |
Evaluation of the biocompatibility of a new biomembrane |
title_fullStr |
Evaluation of the biocompatibility of a new biomembrane |
title_full_unstemmed |
Evaluation of the biocompatibility of a new biomembrane |
title_sort |
Evaluation of the biocompatibility of a new biomembrane |
author |
Mrue,Fatima |
author_facet |
Mrue,Fatima Netto,Joaquim Coutinho Ceneviva,Reginaldo Lachat,João José Thomazini,José Antônio Tambelini,Helder |
author_role |
author |
author2 |
Netto,Joaquim Coutinho Ceneviva,Reginaldo Lachat,João José Thomazini,José Antônio Tambelini,Helder |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Mrue,Fatima Netto,Joaquim Coutinho Ceneviva,Reginaldo Lachat,João José Thomazini,José Antônio Tambelini,Helder |
dc.subject.por.fl_str_mv |
Biomaterial biomembrane biocompatibility |
topic |
Biomaterial biomembrane biocompatibility |
description |
Biocompatibility has been considered one of the most important items to validate a biomaterial for its application in human organisms. The present work evaluates the biocompatibility of a new biomembrane using in vivo assay in different animal species. The experiments to evaluate the cellular reaction were carried out through the implantation of the material into the subcutaneous tissue of animals and the results showed a good reaction of the host tissue without any signal of fibrosis or rejection. The cell adhesion experiments were done by means of the measure of the DNA content on the material surface after its implantation into the subcutaneous tissue of animals and the results showed a growing number of DNA that was proportional to the time of implantation. The healing process was evaluated using a dermal ulcer model and the results showed a good tissue repair resembling a physiologic process. The overall results presented here lead to the conclusion that this new biomembrane is a biocompatible material but more research must be done, as it is a new material desired for medical use. |
publishDate |
2004 |
dc.date.none.fl_str_mv |
2004-06-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-14392004000200010 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-14392004000200010 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S1516-14392004000200010 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
ABM, ABC, ABPol |
publisher.none.fl_str_mv |
ABM, ABC, ABPol |
dc.source.none.fl_str_mv |
Materials Research v.7 n.2 2004 reponame:Materials research (São Carlos. Online) instname:Universidade Federal de São Carlos (UFSCAR) instacron:ABM ABC ABPOL |
instname_str |
Universidade Federal de São Carlos (UFSCAR) |
instacron_str |
ABM ABC ABPOL |
institution |
ABM ABC ABPOL |
reponame_str |
Materials research (São Carlos. Online) |
collection |
Materials research (São Carlos. Online) |
repository.name.fl_str_mv |
Materials research (São Carlos. Online) - Universidade Federal de São Carlos (UFSCAR) |
repository.mail.fl_str_mv |
dedz@power.ufscar.br |
_version_ |
1754212657701847040 |