Preparation, Characterization and Biological Studies of Β-TCP and Β-TCP/Al2O3 Scaffolds Obtained by Gel-Casting of Foams
Main Author: | |
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Publication Date: | 2017 |
Other Authors: | , , , , , |
Format: | Article |
Language: | eng |
Source: | Materials research (São Carlos. Online) |
Download full: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-14392017000400973 |
Summary: | Replacement tissues for tissue engineering can be produced by seeding human cells onto scaffolds. In order to guarantee adequate bio-compatibility, porosity and mechanical resistance for promoting cellular growth, proliferation and differentiation within scaffold structures, it is necessary to investigate and improve materials and processing routes. β-tricalcium phosphate can be considered a very suitable bio-ceramic material for bone therapy because of its biocompatibility, osteo-conductivity and neo-vascularization potential. Alumina is commonly used as a sintering additive. In this study, β-TCP and β-TCP/Al2O3 scaffolds were obtained by gel-casting method. The scaffolds showed high porosity (86-88%) and pore sizes ranging from 200 to 500 µm. Even though alumina did not promote improvement in β-TCP/Al2O3 scaffolds in terms of mechanical performance, they showed great cytocompatibility as there was no cytotoxic and genotoxic effect. Therefore, β-TCP and β-TCP/Al2O3 scaffolds are good candidates for application in tissue engineering. |
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Preparation, Characterization and Biological Studies of Β-TCP and Β-TCP/Al2O3 Scaffolds Obtained by Gel-Casting of FoamsTricalcium phosphatealuminagel-casting methodcytocompatibilityscaffoldsReplacement tissues for tissue engineering can be produced by seeding human cells onto scaffolds. In order to guarantee adequate bio-compatibility, porosity and mechanical resistance for promoting cellular growth, proliferation and differentiation within scaffold structures, it is necessary to investigate and improve materials and processing routes. β-tricalcium phosphate can be considered a very suitable bio-ceramic material for bone therapy because of its biocompatibility, osteo-conductivity and neo-vascularization potential. Alumina is commonly used as a sintering additive. In this study, β-TCP and β-TCP/Al2O3 scaffolds were obtained by gel-casting method. The scaffolds showed high porosity (86-88%) and pore sizes ranging from 200 to 500 µm. Even though alumina did not promote improvement in β-TCP/Al2O3 scaffolds in terms of mechanical performance, they showed great cytocompatibility as there was no cytotoxic and genotoxic effect. Therefore, β-TCP and β-TCP/Al2O3 scaffolds are good candidates for application in tissue engineering.ABM, ABC, ABPol2017-08-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-14392017000400973Materials Research v.20 n.4 2017reponame:Materials research (São Carlos. Online)instname:Universidade Federal de São Carlos (UFSCAR)instacron:ABM ABC ABPOL10.1590/1980-5373-mr-2016-0467info:eu-repo/semantics/openAccessSiqueira,LilianPaula,Cynthia Guimarães deMotisuke,MarianaGouveia,Rubia FigueredoCamargo,Samira Esteves AfonsoMilhan,Noala Vicensoto MoreiraTrichês,Eliandra de Sousaeng2017-09-05T00:00:00Zoai:scielo:S1516-14392017000400973Revistahttp://www.scielo.br/mrPUBhttps://old.scielo.br/oai/scielo-oai.phpdedz@power.ufscar.br1980-53731516-1439opendoar:2017-09-05T00:00Materials research (São Carlos. Online) - Universidade Federal de São Carlos (UFSCAR)false |
dc.title.none.fl_str_mv |
Preparation, Characterization and Biological Studies of Β-TCP and Β-TCP/Al2O3 Scaffolds Obtained by Gel-Casting of Foams |
title |
Preparation, Characterization and Biological Studies of Β-TCP and Β-TCP/Al2O3 Scaffolds Obtained by Gel-Casting of Foams |
spellingShingle |
Preparation, Characterization and Biological Studies of Β-TCP and Β-TCP/Al2O3 Scaffolds Obtained by Gel-Casting of Foams Siqueira,Lilian Tricalcium phosphate alumina gel-casting method cytocompatibility scaffolds |
title_short |
Preparation, Characterization and Biological Studies of Β-TCP and Β-TCP/Al2O3 Scaffolds Obtained by Gel-Casting of Foams |
title_full |
Preparation, Characterization and Biological Studies of Β-TCP and Β-TCP/Al2O3 Scaffolds Obtained by Gel-Casting of Foams |
title_fullStr |
Preparation, Characterization and Biological Studies of Β-TCP and Β-TCP/Al2O3 Scaffolds Obtained by Gel-Casting of Foams |
title_full_unstemmed |
Preparation, Characterization and Biological Studies of Β-TCP and Β-TCP/Al2O3 Scaffolds Obtained by Gel-Casting of Foams |
title_sort |
Preparation, Characterization and Biological Studies of Β-TCP and Β-TCP/Al2O3 Scaffolds Obtained by Gel-Casting of Foams |
author |
Siqueira,Lilian |
author_facet |
Siqueira,Lilian Paula,Cynthia Guimarães de Motisuke,Mariana Gouveia,Rubia Figueredo Camargo,Samira Esteves Afonso Milhan,Noala Vicensoto Moreira Trichês,Eliandra de Sousa |
author_role |
author |
author2 |
Paula,Cynthia Guimarães de Motisuke,Mariana Gouveia,Rubia Figueredo Camargo,Samira Esteves Afonso Milhan,Noala Vicensoto Moreira Trichês,Eliandra de Sousa |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Siqueira,Lilian Paula,Cynthia Guimarães de Motisuke,Mariana Gouveia,Rubia Figueredo Camargo,Samira Esteves Afonso Milhan,Noala Vicensoto Moreira Trichês,Eliandra de Sousa |
dc.subject.por.fl_str_mv |
Tricalcium phosphate alumina gel-casting method cytocompatibility scaffolds |
topic |
Tricalcium phosphate alumina gel-casting method cytocompatibility scaffolds |
description |
Replacement tissues for tissue engineering can be produced by seeding human cells onto scaffolds. In order to guarantee adequate bio-compatibility, porosity and mechanical resistance for promoting cellular growth, proliferation and differentiation within scaffold structures, it is necessary to investigate and improve materials and processing routes. β-tricalcium phosphate can be considered a very suitable bio-ceramic material for bone therapy because of its biocompatibility, osteo-conductivity and neo-vascularization potential. Alumina is commonly used as a sintering additive. In this study, β-TCP and β-TCP/Al2O3 scaffolds were obtained by gel-casting method. The scaffolds showed high porosity (86-88%) and pore sizes ranging from 200 to 500 µm. Even though alumina did not promote improvement in β-TCP/Al2O3 scaffolds in terms of mechanical performance, they showed great cytocompatibility as there was no cytotoxic and genotoxic effect. Therefore, β-TCP and β-TCP/Al2O3 scaffolds are good candidates for application in tissue engineering. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017-08-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-14392017000400973 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-14392017000400973 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/1980-5373-mr-2016-0467 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
ABM, ABC, ABPol |
publisher.none.fl_str_mv |
ABM, ABC, ABPol |
dc.source.none.fl_str_mv |
Materials Research v.20 n.4 2017 reponame:Materials research (São Carlos. Online) instname:Universidade Federal de São Carlos (UFSCAR) instacron:ABM ABC ABPOL |
instname_str |
Universidade Federal de São Carlos (UFSCAR) |
instacron_str |
ABM ABC ABPOL |
institution |
ABM ABC ABPOL |
reponame_str |
Materials research (São Carlos. Online) |
collection |
Materials research (São Carlos. Online) |
repository.name.fl_str_mv |
Materials research (São Carlos. Online) - Universidade Federal de São Carlos (UFSCAR) |
repository.mail.fl_str_mv |
dedz@power.ufscar.br |
_version_ |
1754212671032393728 |