Preparation, characterization and biological studies of β-TCP and β-TCP/Al2O3 scaffolds obtained by gel-casting of foams
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1590/1980-5373-MR-2016-0467 http://hdl.handle.net/11449/170125 |
Resumo: | Replacement tissues for tissue engineering can be produced by seeding human cells onto scaffolds. In order to guarantee adequate bio-compatibility, porosity and mechanical resistance for promoting cellular growth, proliferation and differentiation within scaffold structures, it is necessary to investigate and improve materials and processing routes. β-tricalcium phosphate can be considered a very suitable bio-ceramic material for bone therapy because of its biocompatibility, osteo-conductivity and neovascularization potential. Alumina is commonly used as a sintering additive. In this study, β-TCP and β-TCP/Al2O3 scaffolds were obtained by gel-casting method. The scaffolds showed high porosity (86- 88%) and pore sizes ranging from 200 to 500 μm. Even though alumina did not promote improvement in β-TCP/Al2O3 scaffolds in terms of mechanical performance, they showed great cytocompatibility as there was no cytotoxic and genotoxic effect. Therefore, β-TCP and β-TCP/Al2O3 scaffolds are good candidates for application in tissue engineering. |
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Preparation, characterization and biological studies of β-TCP and β-TCP/Al2O3 scaffolds obtained by gel-casting of foamsAluminaCytocompatibilityGel-casting methodScaffoldsTricalcium phosphateReplacement tissues for tissue engineering can be produced by seeding human cells onto scaffolds. In order to guarantee adequate bio-compatibility, porosity and mechanical resistance for promoting cellular growth, proliferation and differentiation within scaffold structures, it is necessary to investigate and improve materials and processing routes. β-tricalcium phosphate can be considered a very suitable bio-ceramic material for bone therapy because of its biocompatibility, osteo-conductivity and neovascularization potential. Alumina is commonly used as a sintering additive. In this study, β-TCP and β-TCP/Al2O3 scaffolds were obtained by gel-casting method. The scaffolds showed high porosity (86- 88%) and pore sizes ranging from 200 to 500 μm. Even though alumina did not promote improvement in β-TCP/Al2O3 scaffolds in terms of mechanical performance, they showed great cytocompatibility as there was no cytotoxic and genotoxic effect. Therefore, β-TCP and β-TCP/Al2O3 scaffolds are good candidates for application in tissue engineering.Bioceramics Laboratory (BIOCERAM) Science and Technology Institute - ICT Universidade Federal de São Paulo - UNIFESP, 330 Talim StBrazilian Nanotechnology National Laboratory (LNNANO) Centro Nacional de Pesquisa em Energia e Materiais - CNPEM, P.O. Box 6192Department of Biosciences and Oral Diagnosis School of Dentistry Universidade Estadual Paulista Júlio de Mesquita Filho - UNESP, 777 Engenheiro Francisco José Longo AvenueDepartment of Biosciences and Oral Diagnosis School of Dentistry Universidade Estadual Paulista Júlio de Mesquita Filho - UNESP, 777 Engenheiro Francisco José Longo AvenueUniversidade Federal de São Paulo (UNIFESP)Centro Nacional de Pesquisa em Energia e Materiais - CNPEMUniversidade Estadual Paulista (Unesp)Siqueira, LilianDe Paula, Cynthia GuimarãesMotisuke, MarianaGouveia, Rubia FigueredoCamargo, Samira Esteves Afonso [UNESP]Milhan, Noala Vicensoto Moreira [UNESP]De Sousa Trichês, Eliandra2018-12-11T16:49:23Z2018-12-11T16:49:23Z2017-07-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article973-983application/pdfhttp://dx.doi.org/10.1590/1980-5373-MR-2016-0467Materials Research, v. 20, n. 4, p. 973-983, 2017.1516-1439http://hdl.handle.net/11449/17012510.1590/1980-5373-MR-2016-0467S1516-143920170004009732-s2.0-85029485663S1516-14392017000400973.pdfScopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengMaterials Research0,398info:eu-repo/semantics/openAccess2023-10-14T06:09:14Zoai:repositorio.unesp.br:11449/170125Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462023-10-14T06:09:14Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Preparation, characterization and biological studies of β-TCP and β-TCP/Al2O3 scaffolds obtained by gel-casting of foams |
title |
Preparation, characterization and biological studies of β-TCP and β-TCP/Al2O3 scaffolds obtained by gel-casting of foams |
spellingShingle |
Preparation, characterization and biological studies of β-TCP and β-TCP/Al2O3 scaffolds obtained by gel-casting of foams Siqueira, Lilian Alumina Cytocompatibility Gel-casting method Scaffolds Tricalcium phosphate |
title_short |
Preparation, characterization and biological studies of β-TCP and β-TCP/Al2O3 scaffolds obtained by gel-casting of foams |
title_full |
Preparation, characterization and biological studies of β-TCP and β-TCP/Al2O3 scaffolds obtained by gel-casting of foams |
title_fullStr |
Preparation, characterization and biological studies of β-TCP and β-TCP/Al2O3 scaffolds obtained by gel-casting of foams |
title_full_unstemmed |
Preparation, characterization and biological studies of β-TCP and β-TCP/Al2O3 scaffolds obtained by gel-casting of foams |
title_sort |
Preparation, characterization and biological studies of β-TCP and β-TCP/Al2O3 scaffolds obtained by gel-casting of foams |
author |
Siqueira, Lilian |
author_facet |
Siqueira, Lilian De Paula, Cynthia Guimarães Motisuke, Mariana Gouveia, Rubia Figueredo Camargo, Samira Esteves Afonso [UNESP] Milhan, Noala Vicensoto Moreira [UNESP] De Sousa Trichês, Eliandra |
author_role |
author |
author2 |
De Paula, Cynthia Guimarães Motisuke, Mariana Gouveia, Rubia Figueredo Camargo, Samira Esteves Afonso [UNESP] Milhan, Noala Vicensoto Moreira [UNESP] De Sousa Trichês, Eliandra |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Federal de São Paulo (UNIFESP) Centro Nacional de Pesquisa em Energia e Materiais - CNPEM Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Siqueira, Lilian De Paula, Cynthia Guimarães Motisuke, Mariana Gouveia, Rubia Figueredo Camargo, Samira Esteves Afonso [UNESP] Milhan, Noala Vicensoto Moreira [UNESP] De Sousa Trichês, Eliandra |
dc.subject.por.fl_str_mv |
Alumina Cytocompatibility Gel-casting method Scaffolds Tricalcium phosphate |
topic |
Alumina Cytocompatibility Gel-casting method Scaffolds Tricalcium phosphate |
description |
Replacement tissues for tissue engineering can be produced by seeding human cells onto scaffolds. In order to guarantee adequate bio-compatibility, porosity and mechanical resistance for promoting cellular growth, proliferation and differentiation within scaffold structures, it is necessary to investigate and improve materials and processing routes. β-tricalcium phosphate can be considered a very suitable bio-ceramic material for bone therapy because of its biocompatibility, osteo-conductivity and neovascularization potential. Alumina is commonly used as a sintering additive. In this study, β-TCP and β-TCP/Al2O3 scaffolds were obtained by gel-casting method. The scaffolds showed high porosity (86- 88%) and pore sizes ranging from 200 to 500 μm. Even though alumina did not promote improvement in β-TCP/Al2O3 scaffolds in terms of mechanical performance, they showed great cytocompatibility as there was no cytotoxic and genotoxic effect. Therefore, β-TCP and β-TCP/Al2O3 scaffolds are good candidates for application in tissue engineering. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017-07-01 2018-12-11T16:49:23Z 2018-12-11T16:49:23Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1590/1980-5373-MR-2016-0467 Materials Research, v. 20, n. 4, p. 973-983, 2017. 1516-1439 http://hdl.handle.net/11449/170125 10.1590/1980-5373-MR-2016-0467 S1516-14392017000400973 2-s2.0-85029485663 S1516-14392017000400973.pdf |
url |
http://dx.doi.org/10.1590/1980-5373-MR-2016-0467 http://hdl.handle.net/11449/170125 |
identifier_str_mv |
Materials Research, v. 20, n. 4, p. 973-983, 2017. 1516-1439 10.1590/1980-5373-MR-2016-0467 S1516-14392017000400973 2-s2.0-85029485663 S1516-14392017000400973.pdf |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Materials Research 0,398 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
973-983 application/pdf |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1797789395722436608 |