Preparation, Characterization and Biological Studies of Β-TCP and Β-TCP/Al2O3 Scaffolds Obtained by Gel-Casting of Foams

Bibliographic Details
Main Author: Siqueira,Lilian
Publication Date: 2017
Other Authors: Paula,Cynthia Guimarães de, Motisuke,Mariana, Gouveia,Rubia Figueredo, Camargo,Samira Esteves Afonso, Milhan,Noala Vicensoto Moreira, Trichês,Eliandra de Sousa
Format: Article
Language: eng
Source: Materials research (São Carlos. Online)
Download full: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-14392017000400973
Summary: Replacement tissues for tissue engineering can be produced by seeding human cells onto scaffolds. In order to guarantee adequate bio-compatibility, porosity and mechanical resistance for promoting cellular growth, proliferation and differentiation within scaffold structures, it is necessary to investigate and improve materials and processing routes. β-tricalcium phosphate can be considered a very suitable bio-ceramic material for bone therapy because of its biocompatibility, osteo-conductivity and neo-vascularization potential. Alumina is commonly used as a sintering additive. In this study, β-TCP and β-TCP/Al2O3 scaffolds were obtained by gel-casting method. The scaffolds showed high porosity (86-88%) and pore sizes ranging from 200 to 500 µm. Even though alumina did not promote improvement in β-TCP/Al2O3 scaffolds in terms of mechanical performance, they showed great cytocompatibility as there was no cytotoxic and genotoxic effect. Therefore, β-TCP and β-TCP/Al2O3 scaffolds are good candidates for application in tissue engineering.
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spelling Preparation, Characterization and Biological Studies of Β-TCP and Β-TCP/Al2O3 Scaffolds Obtained by Gel-Casting of FoamsTricalcium phosphatealuminagel-casting methodcytocompatibilityscaffoldsReplacement tissues for tissue engineering can be produced by seeding human cells onto scaffolds. In order to guarantee adequate bio-compatibility, porosity and mechanical resistance for promoting cellular growth, proliferation and differentiation within scaffold structures, it is necessary to investigate and improve materials and processing routes. β-tricalcium phosphate can be considered a very suitable bio-ceramic material for bone therapy because of its biocompatibility, osteo-conductivity and neo-vascularization potential. Alumina is commonly used as a sintering additive. In this study, β-TCP and β-TCP/Al2O3 scaffolds were obtained by gel-casting method. The scaffolds showed high porosity (86-88%) and pore sizes ranging from 200 to 500 µm. Even though alumina did not promote improvement in β-TCP/Al2O3 scaffolds in terms of mechanical performance, they showed great cytocompatibility as there was no cytotoxic and genotoxic effect. Therefore, β-TCP and β-TCP/Al2O3 scaffolds are good candidates for application in tissue engineering.ABM, ABC, ABPol2017-08-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-14392017000400973Materials Research v.20 n.4 2017reponame:Materials research (São Carlos. Online)instname:Universidade Federal de São Carlos (UFSCAR)instacron:ABM ABC ABPOL10.1590/1980-5373-mr-2016-0467info:eu-repo/semantics/openAccessSiqueira,LilianPaula,Cynthia Guimarães deMotisuke,MarianaGouveia,Rubia FigueredoCamargo,Samira Esteves AfonsoMilhan,Noala Vicensoto MoreiraTrichês,Eliandra de Sousaeng2017-09-05T00:00:00Zoai:scielo:S1516-14392017000400973Revistahttp://www.scielo.br/mrPUBhttps://old.scielo.br/oai/scielo-oai.phpdedz@power.ufscar.br1980-53731516-1439opendoar:2017-09-05T00:00Materials research (São Carlos. Online) - Universidade Federal de São Carlos (UFSCAR)false
dc.title.none.fl_str_mv Preparation, Characterization and Biological Studies of Β-TCP and Β-TCP/Al2O3 Scaffolds Obtained by Gel-Casting of Foams
title Preparation, Characterization and Biological Studies of Β-TCP and Β-TCP/Al2O3 Scaffolds Obtained by Gel-Casting of Foams
spellingShingle Preparation, Characterization and Biological Studies of Β-TCP and Β-TCP/Al2O3 Scaffolds Obtained by Gel-Casting of Foams
Siqueira,Lilian
Tricalcium phosphate
alumina
gel-casting method
cytocompatibility
scaffolds
title_short Preparation, Characterization and Biological Studies of Β-TCP and Β-TCP/Al2O3 Scaffolds Obtained by Gel-Casting of Foams
title_full Preparation, Characterization and Biological Studies of Β-TCP and Β-TCP/Al2O3 Scaffolds Obtained by Gel-Casting of Foams
title_fullStr Preparation, Characterization and Biological Studies of Β-TCP and Β-TCP/Al2O3 Scaffolds Obtained by Gel-Casting of Foams
title_full_unstemmed Preparation, Characterization and Biological Studies of Β-TCP and Β-TCP/Al2O3 Scaffolds Obtained by Gel-Casting of Foams
title_sort Preparation, Characterization and Biological Studies of Β-TCP and Β-TCP/Al2O3 Scaffolds Obtained by Gel-Casting of Foams
author Siqueira,Lilian
author_facet Siqueira,Lilian
Paula,Cynthia Guimarães de
Motisuke,Mariana
Gouveia,Rubia Figueredo
Camargo,Samira Esteves Afonso
Milhan,Noala Vicensoto Moreira
Trichês,Eliandra de Sousa
author_role author
author2 Paula,Cynthia Guimarães de
Motisuke,Mariana
Gouveia,Rubia Figueredo
Camargo,Samira Esteves Afonso
Milhan,Noala Vicensoto Moreira
Trichês,Eliandra de Sousa
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Siqueira,Lilian
Paula,Cynthia Guimarães de
Motisuke,Mariana
Gouveia,Rubia Figueredo
Camargo,Samira Esteves Afonso
Milhan,Noala Vicensoto Moreira
Trichês,Eliandra de Sousa
dc.subject.por.fl_str_mv Tricalcium phosphate
alumina
gel-casting method
cytocompatibility
scaffolds
topic Tricalcium phosphate
alumina
gel-casting method
cytocompatibility
scaffolds
description Replacement tissues for tissue engineering can be produced by seeding human cells onto scaffolds. In order to guarantee adequate bio-compatibility, porosity and mechanical resistance for promoting cellular growth, proliferation and differentiation within scaffold structures, it is necessary to investigate and improve materials and processing routes. β-tricalcium phosphate can be considered a very suitable bio-ceramic material for bone therapy because of its biocompatibility, osteo-conductivity and neo-vascularization potential. Alumina is commonly used as a sintering additive. In this study, β-TCP and β-TCP/Al2O3 scaffolds were obtained by gel-casting method. The scaffolds showed high porosity (86-88%) and pore sizes ranging from 200 to 500 µm. Even though alumina did not promote improvement in β-TCP/Al2O3 scaffolds in terms of mechanical performance, they showed great cytocompatibility as there was no cytotoxic and genotoxic effect. Therefore, β-TCP and β-TCP/Al2O3 scaffolds are good candidates for application in tissue engineering.
publishDate 2017
dc.date.none.fl_str_mv 2017-08-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-14392017000400973
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-14392017000400973
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/1980-5373-mr-2016-0467
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv ABM, ABC, ABPol
publisher.none.fl_str_mv ABM, ABC, ABPol
dc.source.none.fl_str_mv Materials Research v.20 n.4 2017
reponame:Materials research (São Carlos. Online)
instname:Universidade Federal de São Carlos (UFSCAR)
instacron:ABM ABC ABPOL
instname_str Universidade Federal de São Carlos (UFSCAR)
instacron_str ABM ABC ABPOL
institution ABM ABC ABPOL
reponame_str Materials research (São Carlos. Online)
collection Materials research (São Carlos. Online)
repository.name.fl_str_mv Materials research (São Carlos. Online) - Universidade Federal de São Carlos (UFSCAR)
repository.mail.fl_str_mv dedz@power.ufscar.br
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