Brain atrophy at onset and physical disability in multiple sclerosis
Main Author: | |
---|---|
Publication Date: | 2012 |
Other Authors: | , , , |
Format: | Article |
Language: | eng |
Source: | Arquivos de neuro-psiquiatria (Online) |
Download full: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2012001000003 |
Summary: | The aim of this study was to investigate if brain atrophy in multiple sclerosis (MS) patients during the disease onset predicts long term disability. METHODS: MS patients with follow-up time of at least 7 years from disease onset and with baseline and second magnetic resonance 12 months later were included to measure brain atrophy. Expanded Disability Status Scale (EDSS) was categorized in three groups, EDSS=0, EDSS=1 and 2.5 and EDSS>2.5, and used as disability measure. RESULTS: Twenty-six patients were included. Mean atrophy during the first year in patients that reached an EDSS≥3 was -0.76±0.45 %, in patients with an EDSS between 1 and 2.5 was -0.59±0.56, while in patients with an EDSS of 0 it was -0.38±0.42 (p=0.003). DISCUSSION: Brain atrophy rates during the first year of disease were predictive of disease progression in our population. |
id |
ABNEURO-1_14ca5d2c188160baada2d210c37982f5 |
---|---|
oai_identifier_str |
oai:scielo:S0004-282X2012001000003 |
network_acronym_str |
ABNEURO-1 |
network_name_str |
Arquivos de neuro-psiquiatria (Online) |
repository_id_str |
|
spelling |
Brain atrophy at onset and physical disability in multiple sclerosismultiple sclerosisbrain atrophyExpanded Disability Status ScaleThe aim of this study was to investigate if brain atrophy in multiple sclerosis (MS) patients during the disease onset predicts long term disability. METHODS: MS patients with follow-up time of at least 7 years from disease onset and with baseline and second magnetic resonance 12 months later were included to measure brain atrophy. Expanded Disability Status Scale (EDSS) was categorized in three groups, EDSS=0, EDSS=1 and 2.5 and EDSS>2.5, and used as disability measure. RESULTS: Twenty-six patients were included. Mean atrophy during the first year in patients that reached an EDSS≥3 was -0.76±0.45 %, in patients with an EDSS between 1 and 2.5 was -0.59±0.56, while in patients with an EDSS of 0 it was -0.38±0.42 (p=0.003). DISCUSSION: Brain atrophy rates during the first year of disease were predictive of disease progression in our population.Academia Brasileira de Neurologia - ABNEURO2012-10-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2012001000003Arquivos de Neuro-Psiquiatria v.70 n.10 2012reponame:Arquivos de neuro-psiquiatria (Online)instname:Academia Brasileira de Neurologiainstacron:ABNEURO10.1590/S0004-282X2012001000003info:eu-repo/semantics/openAccessRojas,Juan IgnacioPatrucco,LilianaBesada,CristinaBengolea,LauraCristiano,Edgardoeng2015-07-07T00:00:00Zoai:scielo:S0004-282X2012001000003Revistahttp://www.scielo.br/anphttps://old.scielo.br/oai/scielo-oai.php||revista.arquivos@abneuro.org1678-42270004-282Xopendoar:2015-07-07T00:00Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologiafalse |
dc.title.none.fl_str_mv |
Brain atrophy at onset and physical disability in multiple sclerosis |
title |
Brain atrophy at onset and physical disability in multiple sclerosis |
spellingShingle |
Brain atrophy at onset and physical disability in multiple sclerosis Rojas,Juan Ignacio multiple sclerosis brain atrophy Expanded Disability Status Scale |
title_short |
Brain atrophy at onset and physical disability in multiple sclerosis |
title_full |
Brain atrophy at onset and physical disability in multiple sclerosis |
title_fullStr |
Brain atrophy at onset and physical disability in multiple sclerosis |
title_full_unstemmed |
Brain atrophy at onset and physical disability in multiple sclerosis |
title_sort |
Brain atrophy at onset and physical disability in multiple sclerosis |
author |
Rojas,Juan Ignacio |
author_facet |
Rojas,Juan Ignacio Patrucco,Liliana Besada,Cristina Bengolea,Laura Cristiano,Edgardo |
author_role |
author |
author2 |
Patrucco,Liliana Besada,Cristina Bengolea,Laura Cristiano,Edgardo |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Rojas,Juan Ignacio Patrucco,Liliana Besada,Cristina Bengolea,Laura Cristiano,Edgardo |
dc.subject.por.fl_str_mv |
multiple sclerosis brain atrophy Expanded Disability Status Scale |
topic |
multiple sclerosis brain atrophy Expanded Disability Status Scale |
description |
The aim of this study was to investigate if brain atrophy in multiple sclerosis (MS) patients during the disease onset predicts long term disability. METHODS: MS patients with follow-up time of at least 7 years from disease onset and with baseline and second magnetic resonance 12 months later were included to measure brain atrophy. Expanded Disability Status Scale (EDSS) was categorized in three groups, EDSS=0, EDSS=1 and 2.5 and EDSS>2.5, and used as disability measure. RESULTS: Twenty-six patients were included. Mean atrophy during the first year in patients that reached an EDSS≥3 was -0.76±0.45 %, in patients with an EDSS between 1 and 2.5 was -0.59±0.56, while in patients with an EDSS of 0 it was -0.38±0.42 (p=0.003). DISCUSSION: Brain atrophy rates during the first year of disease were predictive of disease progression in our population. |
publishDate |
2012 |
dc.date.none.fl_str_mv |
2012-10-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2012001000003 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2012001000003 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0004-282X2012001000003 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Academia Brasileira de Neurologia - ABNEURO |
publisher.none.fl_str_mv |
Academia Brasileira de Neurologia - ABNEURO |
dc.source.none.fl_str_mv |
Arquivos de Neuro-Psiquiatria v.70 n.10 2012 reponame:Arquivos de neuro-psiquiatria (Online) instname:Academia Brasileira de Neurologia instacron:ABNEURO |
instname_str |
Academia Brasileira de Neurologia |
instacron_str |
ABNEURO |
institution |
ABNEURO |
reponame_str |
Arquivos de neuro-psiquiatria (Online) |
collection |
Arquivos de neuro-psiquiatria (Online) |
repository.name.fl_str_mv |
Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologia |
repository.mail.fl_str_mv |
||revista.arquivos@abneuro.org |
_version_ |
1754212773810667520 |