Effects of aging on nitrergic neurons in human striatum and subthalamic nucleus

Detalhes bibliográficos
Autor(a) principal: Santos-Lobato,Bruno Lopes dos
Data de Publicação: 2015
Outros Autores: Del-Bel,Elaine Aparecida, Pittella,José Eymard Homem, Tumas,Vitor
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Arquivos de neuro-psiquiatria (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2015000900779
Resumo: Nitric oxide (NO) is a major neurotransmitter associated with motor control in basal ganglia. Movement disorders, as essential tremor and Parkinson’s disease, are more prevalent on aged individuals. We investigated the effects of aging on neuronal density and diameter/area of nitrergic neurons in samples of striatum (caudate and putamen) and subthalamic nucleus of 20 human brains from normal subjects, stained by histochemistry for NADPH-diaphorase and immunohistochemistry for neuronal NO synthase. Our data showed aging does not modify the neuronal density and size of nitrergic neurons in striatum and subthalamic nucleus. These findings suggest a lack of association between aging and morphologic changes on nitrergic neurons.
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spelling Effects of aging on nitrergic neurons in human striatum and subthalamic nucleusnitric oxidebasal gangliastriatumsubthalamic nucleusagingNitric oxide (NO) is a major neurotransmitter associated with motor control in basal ganglia. Movement disorders, as essential tremor and Parkinson’s disease, are more prevalent on aged individuals. We investigated the effects of aging on neuronal density and diameter/area of nitrergic neurons in samples of striatum (caudate and putamen) and subthalamic nucleus of 20 human brains from normal subjects, stained by histochemistry for NADPH-diaphorase and immunohistochemistry for neuronal NO synthase. Our data showed aging does not modify the neuronal density and size of nitrergic neurons in striatum and subthalamic nucleus. These findings suggest a lack of association between aging and morphologic changes on nitrergic neurons.Academia Brasileira de Neurologia - ABNEURO2015-09-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2015000900779Arquivos de Neuro-Psiquiatria v.73 n.9 2015reponame:Arquivos de neuro-psiquiatria (Online)instname:Academia Brasileira de Neurologiainstacron:ABNEURO10.1590/0004-282X20150097info:eu-repo/semantics/openAccessSantos-Lobato,Bruno Lopes dosDel-Bel,Elaine AparecidaPittella,José Eymard HomemTumas,Vitoreng2015-08-31T00:00:00Zoai:scielo:S0004-282X2015000900779Revistahttp://www.scielo.br/anphttps://old.scielo.br/oai/scielo-oai.php||revista.arquivos@abneuro.org1678-42270004-282Xopendoar:2015-08-31T00:00Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologiafalse
dc.title.none.fl_str_mv Effects of aging on nitrergic neurons in human striatum and subthalamic nucleus
title Effects of aging on nitrergic neurons in human striatum and subthalamic nucleus
spellingShingle Effects of aging on nitrergic neurons in human striatum and subthalamic nucleus
Santos-Lobato,Bruno Lopes dos
nitric oxide
basal ganglia
striatum
subthalamic nucleus
aging
title_short Effects of aging on nitrergic neurons in human striatum and subthalamic nucleus
title_full Effects of aging on nitrergic neurons in human striatum and subthalamic nucleus
title_fullStr Effects of aging on nitrergic neurons in human striatum and subthalamic nucleus
title_full_unstemmed Effects of aging on nitrergic neurons in human striatum and subthalamic nucleus
title_sort Effects of aging on nitrergic neurons in human striatum and subthalamic nucleus
author Santos-Lobato,Bruno Lopes dos
author_facet Santos-Lobato,Bruno Lopes dos
Del-Bel,Elaine Aparecida
Pittella,José Eymard Homem
Tumas,Vitor
author_role author
author2 Del-Bel,Elaine Aparecida
Pittella,José Eymard Homem
Tumas,Vitor
author2_role author
author
author
dc.contributor.author.fl_str_mv Santos-Lobato,Bruno Lopes dos
Del-Bel,Elaine Aparecida
Pittella,José Eymard Homem
Tumas,Vitor
dc.subject.por.fl_str_mv nitric oxide
basal ganglia
striatum
subthalamic nucleus
aging
topic nitric oxide
basal ganglia
striatum
subthalamic nucleus
aging
description Nitric oxide (NO) is a major neurotransmitter associated with motor control in basal ganglia. Movement disorders, as essential tremor and Parkinson’s disease, are more prevalent on aged individuals. We investigated the effects of aging on neuronal density and diameter/area of nitrergic neurons in samples of striatum (caudate and putamen) and subthalamic nucleus of 20 human brains from normal subjects, stained by histochemistry for NADPH-diaphorase and immunohistochemistry for neuronal NO synthase. Our data showed aging does not modify the neuronal density and size of nitrergic neurons in striatum and subthalamic nucleus. These findings suggest a lack of association between aging and morphologic changes on nitrergic neurons.
publishDate 2015
dc.date.none.fl_str_mv 2015-09-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2015000900779
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2015000900779
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/0004-282X20150097
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Academia Brasileira de Neurologia - ABNEURO
publisher.none.fl_str_mv Academia Brasileira de Neurologia - ABNEURO
dc.source.none.fl_str_mv Arquivos de Neuro-Psiquiatria v.73 n.9 2015
reponame:Arquivos de neuro-psiquiatria (Online)
instname:Academia Brasileira de Neurologia
instacron:ABNEURO
instname_str Academia Brasileira de Neurologia
instacron_str ABNEURO
institution ABNEURO
reponame_str Arquivos de neuro-psiquiatria (Online)
collection Arquivos de neuro-psiquiatria (Online)
repository.name.fl_str_mv Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologia
repository.mail.fl_str_mv ||revista.arquivos@abneuro.org
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