Effect of acetyl-L-carnitine on Vip-ergic neurons in jejunum submucous plexus of diabetic rats
Autor(a) principal: | |
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Data de Publicação: | 2003 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Arquivos de neuro-psiquiatria (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2003000600014 |
Resumo: | The effect of the treatment with acetyl-L-carnitine (ALC) on neurons releasing the vasoactive intestinal polypeptide (VIP) of the submucous plexus in the jejunum of diabetic rats was the purpose of our investigation. Diabetes (DM) was induced by injecting streptozotocin endovenously (35mg/kg). After sacrificing the animals, the jejunum was collected and processed for VIP detection. Four groups were used: C (non-diabetic), CC (non-diabetic treated with ALC), D (diabetic), DC (diabetes treated with ALC). We analyzed the immunoreactivity and the cellular profile of 126 cell bodies. The treatment with ALC improved some aspects of DM. However, it promoted a small increase in the area of neurons from group CC, suggesting a possible neurotrophic effect. Neurons from groups D and DC showed a large increase in their cellular profile and immunoreactivity when compared to C and CC, suggesting a larger concentration of this neurotransmitter within the neurons that produce it. This observation constitutes a recurrent finding in diabetic animals, suggesting that ALC doesnot interfere in the pathophysiological mechanisms that unchain a higher production and/or neurotransmitter accumulation and increase the profile of the VIP-ergic neurons. |
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Effect of acetyl-L-carnitine on Vip-ergic neurons in jejunum submucous plexus of diabetic ratsacetyl-L-carnitinesubmucous plexusVIPdiabetesjejunumratThe effect of the treatment with acetyl-L-carnitine (ALC) on neurons releasing the vasoactive intestinal polypeptide (VIP) of the submucous plexus in the jejunum of diabetic rats was the purpose of our investigation. Diabetes (DM) was induced by injecting streptozotocin endovenously (35mg/kg). After sacrificing the animals, the jejunum was collected and processed for VIP detection. Four groups were used: C (non-diabetic), CC (non-diabetic treated with ALC), D (diabetic), DC (diabetes treated with ALC). We analyzed the immunoreactivity and the cellular profile of 126 cell bodies. The treatment with ALC improved some aspects of DM. However, it promoted a small increase in the area of neurons from group CC, suggesting a possible neurotrophic effect. Neurons from groups D and DC showed a large increase in their cellular profile and immunoreactivity when compared to C and CC, suggesting a larger concentration of this neurotransmitter within the neurons that produce it. This observation constitutes a recurrent finding in diabetic animals, suggesting that ALC doesnot interfere in the pathophysiological mechanisms that unchain a higher production and/or neurotransmitter accumulation and increase the profile of the VIP-ergic neurons.Academia Brasileira de Neurologia - ABNEURO2003-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2003000600014Arquivos de Neuro-Psiquiatria v.61 n.4 2003reponame:Arquivos de neuro-psiquiatria (Online)instname:Academia Brasileira de Neurologiainstacron:ABNEURO10.1590/S0004-282X2003000600014info:eu-repo/semantics/openAccessDefani,Marli AparecidaZanoni,Jacqueline NelisisNatali,Maria Raquel MarçalBazotte,Roberto BarbosaMiranda-Neto,Marcílio Hubner deeng2004-01-06T00:00:00Zoai:scielo:S0004-282X2003000600014Revistahttp://www.scielo.br/anphttps://old.scielo.br/oai/scielo-oai.php||revista.arquivos@abneuro.org1678-42270004-282Xopendoar:2004-01-06T00:00Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologiafalse |
dc.title.none.fl_str_mv |
Effect of acetyl-L-carnitine on Vip-ergic neurons in jejunum submucous plexus of diabetic rats |
title |
Effect of acetyl-L-carnitine on Vip-ergic neurons in jejunum submucous plexus of diabetic rats |
spellingShingle |
Effect of acetyl-L-carnitine on Vip-ergic neurons in jejunum submucous plexus of diabetic rats Defani,Marli Aparecida acetyl-L-carnitine submucous plexus VIP diabetes jejunum rat |
title_short |
Effect of acetyl-L-carnitine on Vip-ergic neurons in jejunum submucous plexus of diabetic rats |
title_full |
Effect of acetyl-L-carnitine on Vip-ergic neurons in jejunum submucous plexus of diabetic rats |
title_fullStr |
Effect of acetyl-L-carnitine on Vip-ergic neurons in jejunum submucous plexus of diabetic rats |
title_full_unstemmed |
Effect of acetyl-L-carnitine on Vip-ergic neurons in jejunum submucous plexus of diabetic rats |
title_sort |
Effect of acetyl-L-carnitine on Vip-ergic neurons in jejunum submucous plexus of diabetic rats |
author |
Defani,Marli Aparecida |
author_facet |
Defani,Marli Aparecida Zanoni,Jacqueline Nelisis Natali,Maria Raquel Marçal Bazotte,Roberto Barbosa Miranda-Neto,Marcílio Hubner de |
author_role |
author |
author2 |
Zanoni,Jacqueline Nelisis Natali,Maria Raquel Marçal Bazotte,Roberto Barbosa Miranda-Neto,Marcílio Hubner de |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Defani,Marli Aparecida Zanoni,Jacqueline Nelisis Natali,Maria Raquel Marçal Bazotte,Roberto Barbosa Miranda-Neto,Marcílio Hubner de |
dc.subject.por.fl_str_mv |
acetyl-L-carnitine submucous plexus VIP diabetes jejunum rat |
topic |
acetyl-L-carnitine submucous plexus VIP diabetes jejunum rat |
description |
The effect of the treatment with acetyl-L-carnitine (ALC) on neurons releasing the vasoactive intestinal polypeptide (VIP) of the submucous plexus in the jejunum of diabetic rats was the purpose of our investigation. Diabetes (DM) was induced by injecting streptozotocin endovenously (35mg/kg). After sacrificing the animals, the jejunum was collected and processed for VIP detection. Four groups were used: C (non-diabetic), CC (non-diabetic treated with ALC), D (diabetic), DC (diabetes treated with ALC). We analyzed the immunoreactivity and the cellular profile of 126 cell bodies. The treatment with ALC improved some aspects of DM. However, it promoted a small increase in the area of neurons from group CC, suggesting a possible neurotrophic effect. Neurons from groups D and DC showed a large increase in their cellular profile and immunoreactivity when compared to C and CC, suggesting a larger concentration of this neurotransmitter within the neurons that produce it. This observation constitutes a recurrent finding in diabetic animals, suggesting that ALC doesnot interfere in the pathophysiological mechanisms that unchain a higher production and/or neurotransmitter accumulation and increase the profile of the VIP-ergic neurons. |
publishDate |
2003 |
dc.date.none.fl_str_mv |
2003-12-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2003000600014 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2003000600014 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0004-282X2003000600014 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Academia Brasileira de Neurologia - ABNEURO |
publisher.none.fl_str_mv |
Academia Brasileira de Neurologia - ABNEURO |
dc.source.none.fl_str_mv |
Arquivos de Neuro-Psiquiatria v.61 n.4 2003 reponame:Arquivos de neuro-psiquiatria (Online) instname:Academia Brasileira de Neurologia instacron:ABNEURO |
instname_str |
Academia Brasileira de Neurologia |
instacron_str |
ABNEURO |
institution |
ABNEURO |
reponame_str |
Arquivos de neuro-psiquiatria (Online) |
collection |
Arquivos de neuro-psiquiatria (Online) |
repository.name.fl_str_mv |
Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologia |
repository.mail.fl_str_mv |
||revista.arquivos@abneuro.org |
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