Epidemiological features of meningiomas: a single Brazilian center’s experience with 993 cases
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Arquivos de neuro-psiquiatria (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2021000800705 |
Resumo: | ABSTRACT Background: Meningiomas are the most frequent primary central nervous system (CNS) tumors. Their geographical and ethnic characteristics need to be known, in order to enable rational treatment. Objective: To investigate clinical and epidemiological aspects in a series of patients with meningiomas. Methods: Retrospective analysis on the demographic profile, location and histopathology of 993 patients with meningiomas (768 operated and 225 not operated). Results: Meningiomas represented 43.8% of the primary CNS tumors; 6.8% were multiple tumors (14.7% with neurofibromatosis 2) and 0.6% were radiation-induced tumors. The mean ages were 53.0 and 63.9 years for operated and non-operated patients and the female/male ratios were 3.2:1 and 6.3:1. Diagnosis was made later among females. The peak incidences were in the 6th and 7th decades respectively for operated and non-operated patients. The incidence was low at early ages and higher among patients aged 70+ years. The meningiomas were intracranial in 96.5% and most were WHO grade I (88.9%) and transitional. In the spinal canal (3.5%), they occurred mainly in the dorsal region (all grade I; mostly transitional). The racial distribution was 1.0% in Asian-Brazilians, 87% in Caucasians and 12% in African-Brazilians. 83.4% and 51.6% of the patients were estimated to be recurrence-free at 10 and 20 years, and the mortality rate was 3%. Conclusions: Most of the demographic data were similar to what has been observed in other western centers. Differences were higher incidence of meningiomas, female and older predominance in non-operated patients, predominance in Caucasian, and higher association with neurofibromatosis 2. |
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Epidemiological features of meningiomas: a single Brazilian center’s experience with 993 casesMeningiomaDemographic DataPathologyGeneral SurgeryRisk FactorsNeoplasm Recurrence, LocalABSTRACT Background: Meningiomas are the most frequent primary central nervous system (CNS) tumors. Their geographical and ethnic characteristics need to be known, in order to enable rational treatment. Objective: To investigate clinical and epidemiological aspects in a series of patients with meningiomas. Methods: Retrospective analysis on the demographic profile, location and histopathology of 993 patients with meningiomas (768 operated and 225 not operated). Results: Meningiomas represented 43.8% of the primary CNS tumors; 6.8% were multiple tumors (14.7% with neurofibromatosis 2) and 0.6% were radiation-induced tumors. The mean ages were 53.0 and 63.9 years for operated and non-operated patients and the female/male ratios were 3.2:1 and 6.3:1. Diagnosis was made later among females. The peak incidences were in the 6th and 7th decades respectively for operated and non-operated patients. The incidence was low at early ages and higher among patients aged 70+ years. The meningiomas were intracranial in 96.5% and most were WHO grade I (88.9%) and transitional. In the spinal canal (3.5%), they occurred mainly in the dorsal region (all grade I; mostly transitional). The racial distribution was 1.0% in Asian-Brazilians, 87% in Caucasians and 12% in African-Brazilians. 83.4% and 51.6% of the patients were estimated to be recurrence-free at 10 and 20 years, and the mortality rate was 3%. Conclusions: Most of the demographic data were similar to what has been observed in other western centers. Differences were higher incidence of meningiomas, female and older predominance in non-operated patients, predominance in Caucasian, and higher association with neurofibromatosis 2.Academia Brasileira de Neurologia - ABNEURO2021-08-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2021000800705Arquivos de Neuro-Psiquiatria v.79 n.8 2021reponame:Arquivos de neuro-psiquiatria (Online)instname:Academia Brasileira de Neurologiainstacron:ABNEURO10.1590/0004-282x-anp-2020-0441info:eu-repo/semantics/openAccessColli,Benedicto OscarMachado,Hélio RubensCarlotti Jr,Carlos GilbertoAssirati Jr,João AlbertoOliveira,Ricardo Santos DeGondim,Guilherme Gozzoli PodolskySantos,Antonio Carlos DosNeder,Lucianoeng2021-09-17T00:00:00Zoai:scielo:S0004-282X2021000800705Revistahttp://www.scielo.br/anphttps://old.scielo.br/oai/scielo-oai.php||revista.arquivos@abneuro.org1678-42270004-282Xopendoar:2021-09-17T00:00Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologiafalse |
dc.title.none.fl_str_mv |
Epidemiological features of meningiomas: a single Brazilian center’s experience with 993 cases |
title |
Epidemiological features of meningiomas: a single Brazilian center’s experience with 993 cases |
spellingShingle |
Epidemiological features of meningiomas: a single Brazilian center’s experience with 993 cases Colli,Benedicto Oscar Meningioma Demographic Data Pathology General Surgery Risk Factors Neoplasm Recurrence, Local |
title_short |
Epidemiological features of meningiomas: a single Brazilian center’s experience with 993 cases |
title_full |
Epidemiological features of meningiomas: a single Brazilian center’s experience with 993 cases |
title_fullStr |
Epidemiological features of meningiomas: a single Brazilian center’s experience with 993 cases |
title_full_unstemmed |
Epidemiological features of meningiomas: a single Brazilian center’s experience with 993 cases |
title_sort |
Epidemiological features of meningiomas: a single Brazilian center’s experience with 993 cases |
author |
Colli,Benedicto Oscar |
author_facet |
Colli,Benedicto Oscar Machado,Hélio Rubens Carlotti Jr,Carlos Gilberto Assirati Jr,João Alberto Oliveira,Ricardo Santos De Gondim,Guilherme Gozzoli Podolsky Santos,Antonio Carlos Dos Neder,Luciano |
author_role |
author |
author2 |
Machado,Hélio Rubens Carlotti Jr,Carlos Gilberto Assirati Jr,João Alberto Oliveira,Ricardo Santos De Gondim,Guilherme Gozzoli Podolsky Santos,Antonio Carlos Dos Neder,Luciano |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Colli,Benedicto Oscar Machado,Hélio Rubens Carlotti Jr,Carlos Gilberto Assirati Jr,João Alberto Oliveira,Ricardo Santos De Gondim,Guilherme Gozzoli Podolsky Santos,Antonio Carlos Dos Neder,Luciano |
dc.subject.por.fl_str_mv |
Meningioma Demographic Data Pathology General Surgery Risk Factors Neoplasm Recurrence, Local |
topic |
Meningioma Demographic Data Pathology General Surgery Risk Factors Neoplasm Recurrence, Local |
description |
ABSTRACT Background: Meningiomas are the most frequent primary central nervous system (CNS) tumors. Their geographical and ethnic characteristics need to be known, in order to enable rational treatment. Objective: To investigate clinical and epidemiological aspects in a series of patients with meningiomas. Methods: Retrospective analysis on the demographic profile, location and histopathology of 993 patients with meningiomas (768 operated and 225 not operated). Results: Meningiomas represented 43.8% of the primary CNS tumors; 6.8% were multiple tumors (14.7% with neurofibromatosis 2) and 0.6% were radiation-induced tumors. The mean ages were 53.0 and 63.9 years for operated and non-operated patients and the female/male ratios were 3.2:1 and 6.3:1. Diagnosis was made later among females. The peak incidences were in the 6th and 7th decades respectively for operated and non-operated patients. The incidence was low at early ages and higher among patients aged 70+ years. The meningiomas were intracranial in 96.5% and most were WHO grade I (88.9%) and transitional. In the spinal canal (3.5%), they occurred mainly in the dorsal region (all grade I; mostly transitional). The racial distribution was 1.0% in Asian-Brazilians, 87% in Caucasians and 12% in African-Brazilians. 83.4% and 51.6% of the patients were estimated to be recurrence-free at 10 and 20 years, and the mortality rate was 3%. Conclusions: Most of the demographic data were similar to what has been observed in other western centers. Differences were higher incidence of meningiomas, female and older predominance in non-operated patients, predominance in Caucasian, and higher association with neurofibromatosis 2. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-08-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2021000800705 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2021000800705 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/0004-282x-anp-2020-0441 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Academia Brasileira de Neurologia - ABNEURO |
publisher.none.fl_str_mv |
Academia Brasileira de Neurologia - ABNEURO |
dc.source.none.fl_str_mv |
Arquivos de Neuro-Psiquiatria v.79 n.8 2021 reponame:Arquivos de neuro-psiquiatria (Online) instname:Academia Brasileira de Neurologia instacron:ABNEURO |
instname_str |
Academia Brasileira de Neurologia |
instacron_str |
ABNEURO |
institution |
ABNEURO |
reponame_str |
Arquivos de neuro-psiquiatria (Online) |
collection |
Arquivos de neuro-psiquiatria (Online) |
repository.name.fl_str_mv |
Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologia |
repository.mail.fl_str_mv |
||revista.arquivos@abneuro.org |
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