Improvement in hippocampal kindling analysis through computational processing data

Detalhes bibliográficos
Autor(a) principal: Cordeiro,Joacir Graciolli
Data de Publicação: 2009
Outros Autores: Capurro,Alberto, Aertsen,Ad, Cordeiro,Karina Kohn, Araújo,João Cândido, Schulze-Bonhage,Andreas
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Arquivos de neuro-psiquiatria (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2009000400019
Resumo: The kindling phenomenon is classically investigated in epileptology research. The present study aims to provide further information about hippocampal kindling through computational processing data. Adult Wistar rats were implanted with dorsal hippocampal and frontal neocortical electrodes to perform the experiment. The processing data was obtained using the Spike2 and Matlab softwares. An inverse relationship between the number of "wet dog shakes" and the Racine's motor stages development was found. Moreover it was observed a significant increase in the afterdischarge (AD) duration and its frequency content. The highest frequencies were, however, only reached at the beginning of behavioral seizures. During the primary AD, fast transients (ripples) were registered in both hippocampi superimposed to slower waves. This experiment highlights the usefulness of computational processing applied to animal models of temporal lobe epilepsy and supports a relevant role of the high frequency discharges in temporal epileptogenesis.
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spelling Improvement in hippocampal kindling analysis through computational processing datahippocampal kindlingtemporal epilepsyexperimental modelThe kindling phenomenon is classically investigated in epileptology research. The present study aims to provide further information about hippocampal kindling through computational processing data. Adult Wistar rats were implanted with dorsal hippocampal and frontal neocortical electrodes to perform the experiment. The processing data was obtained using the Spike2 and Matlab softwares. An inverse relationship between the number of "wet dog shakes" and the Racine's motor stages development was found. Moreover it was observed a significant increase in the afterdischarge (AD) duration and its frequency content. The highest frequencies were, however, only reached at the beginning of behavioral seizures. During the primary AD, fast transients (ripples) were registered in both hippocampi superimposed to slower waves. This experiment highlights the usefulness of computational processing applied to animal models of temporal lobe epilepsy and supports a relevant role of the high frequency discharges in temporal epileptogenesis.Academia Brasileira de Neurologia - ABNEURO2009-09-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2009000400019Arquivos de Neuro-Psiquiatria v.67 n.3a 2009reponame:Arquivos de neuro-psiquiatria (Online)instname:Academia Brasileira de Neurologiainstacron:ABNEURO10.1590/S0004-282X2009000400019info:eu-repo/semantics/openAccessCordeiro,Joacir GraciolliCapurro,AlbertoAertsen,AdCordeiro,Karina KohnAraújo,João CândidoSchulze-Bonhage,Andreaseng2009-08-21T00:00:00Zoai:scielo:S0004-282X2009000400019Revistahttp://www.scielo.br/anphttps://old.scielo.br/oai/scielo-oai.php||revista.arquivos@abneuro.org1678-42270004-282Xopendoar:2009-08-21T00:00Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologiafalse
dc.title.none.fl_str_mv Improvement in hippocampal kindling analysis through computational processing data
title Improvement in hippocampal kindling analysis through computational processing data
spellingShingle Improvement in hippocampal kindling analysis through computational processing data
Cordeiro,Joacir Graciolli
hippocampal kindling
temporal epilepsy
experimental model
title_short Improvement in hippocampal kindling analysis through computational processing data
title_full Improvement in hippocampal kindling analysis through computational processing data
title_fullStr Improvement in hippocampal kindling analysis through computational processing data
title_full_unstemmed Improvement in hippocampal kindling analysis through computational processing data
title_sort Improvement in hippocampal kindling analysis through computational processing data
author Cordeiro,Joacir Graciolli
author_facet Cordeiro,Joacir Graciolli
Capurro,Alberto
Aertsen,Ad
Cordeiro,Karina Kohn
Araújo,João Cândido
Schulze-Bonhage,Andreas
author_role author
author2 Capurro,Alberto
Aertsen,Ad
Cordeiro,Karina Kohn
Araújo,João Cândido
Schulze-Bonhage,Andreas
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Cordeiro,Joacir Graciolli
Capurro,Alberto
Aertsen,Ad
Cordeiro,Karina Kohn
Araújo,João Cândido
Schulze-Bonhage,Andreas
dc.subject.por.fl_str_mv hippocampal kindling
temporal epilepsy
experimental model
topic hippocampal kindling
temporal epilepsy
experimental model
description The kindling phenomenon is classically investigated in epileptology research. The present study aims to provide further information about hippocampal kindling through computational processing data. Adult Wistar rats were implanted with dorsal hippocampal and frontal neocortical electrodes to perform the experiment. The processing data was obtained using the Spike2 and Matlab softwares. An inverse relationship between the number of "wet dog shakes" and the Racine's motor stages development was found. Moreover it was observed a significant increase in the afterdischarge (AD) duration and its frequency content. The highest frequencies were, however, only reached at the beginning of behavioral seizures. During the primary AD, fast transients (ripples) were registered in both hippocampi superimposed to slower waves. This experiment highlights the usefulness of computational processing applied to animal models of temporal lobe epilepsy and supports a relevant role of the high frequency discharges in temporal epileptogenesis.
publishDate 2009
dc.date.none.fl_str_mv 2009-09-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2009000400019
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2009000400019
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0004-282X2009000400019
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Academia Brasileira de Neurologia - ABNEURO
publisher.none.fl_str_mv Academia Brasileira de Neurologia - ABNEURO
dc.source.none.fl_str_mv Arquivos de Neuro-Psiquiatria v.67 n.3a 2009
reponame:Arquivos de neuro-psiquiatria (Online)
instname:Academia Brasileira de Neurologia
instacron:ABNEURO
instname_str Academia Brasileira de Neurologia
instacron_str ABNEURO
institution ABNEURO
reponame_str Arquivos de neuro-psiquiatria (Online)
collection Arquivos de neuro-psiquiatria (Online)
repository.name.fl_str_mv Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologia
repository.mail.fl_str_mv ||revista.arquivos@abneuro.org
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