Sjögren syndrome and neuromyelitis optica spectrum disorder co-exist in a common autoimmune milieu
Autor(a) principal: | |
---|---|
Data de Publicação: | 2014 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Arquivos de neuro-psiquiatria (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2014000800619 |
Resumo: | The relationship between Sjögren’s syndrome (SS) and neuromyelitis optica spectrum disorder (NMOSD) is not completely understood. We report two patients with both conditions and review 47 other previously reported cases meeting currently accepted diagnostic criteria, from 17 articles extracted from PubMed. Out of 44 patients whose gender was informed, 42 were females. Mean age at onset of neurological manifestation was 36.2 years (10-74). Serum anti-AQP4-IgG was positive in 32 patients, borderline in 1, and negative in 4. Our Case 1 was seronegative for AQP4-IgG and had no non-organ-specific autoantibodies other than anti-SSB antibodies. Our Case 2 had serum anti-AQP4, anti-SSA/SSB, anti-thyreoglobulin and anti-acethylcholine-receptor antibodies, as well as clinical hypothyreoidism, but no evidence of myasthenia gravis. Our Cases and others, as previously reported in literature, with similar heterogeneous autoimmune response to aquaporin-4, suggest that SS and NMO co-exist in a common autoimmune milieu which is not dependent on aquaporin-4 autoimmunity. |
id |
ABNEURO-1_488a00dec22d2887386ef0fe19904765 |
---|---|
oai_identifier_str |
oai:scielo:S0004-282X2014000800619 |
network_acronym_str |
ABNEURO-1 |
network_name_str |
Arquivos de neuro-psiquiatria (Online) |
repository_id_str |
|
spelling |
Sjögren syndrome and neuromyelitis optica spectrum disorder co-exist in a common autoimmune milieuneuromyelitis optica spectrum disordersneuromyelitis opticaSjögren?s syndromeautoimmunityAQP4-IgGThe relationship between Sjögren’s syndrome (SS) and neuromyelitis optica spectrum disorder (NMOSD) is not completely understood. We report two patients with both conditions and review 47 other previously reported cases meeting currently accepted diagnostic criteria, from 17 articles extracted from PubMed. Out of 44 patients whose gender was informed, 42 were females. Mean age at onset of neurological manifestation was 36.2 years (10-74). Serum anti-AQP4-IgG was positive in 32 patients, borderline in 1, and negative in 4. Our Case 1 was seronegative for AQP4-IgG and had no non-organ-specific autoantibodies other than anti-SSB antibodies. Our Case 2 had serum anti-AQP4, anti-SSA/SSB, anti-thyreoglobulin and anti-acethylcholine-receptor antibodies, as well as clinical hypothyreoidism, but no evidence of myasthenia gravis. Our Cases and others, as previously reported in literature, with similar heterogeneous autoimmune response to aquaporin-4, suggest that SS and NMO co-exist in a common autoimmune milieu which is not dependent on aquaporin-4 autoimmunity.Academia Brasileira de Neurologia - ABNEURO2014-08-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2014000800619Arquivos de Neuro-Psiquiatria v.72 n.8 2014reponame:Arquivos de neuro-psiquiatria (Online)instname:Academia Brasileira de Neurologiainstacron:ABNEURO10.1590/0004-282X20140097info:eu-repo/semantics/openAccessCarvalho,Diogo C.Tironi,Tauana S.Freitas,Denise S.Kleinpaul,RodrigoTalim,Natalia C.Lana-Peixoto,Marco A.eng2014-08-01T00:00:00Zoai:scielo:S0004-282X2014000800619Revistahttp://www.scielo.br/anphttps://old.scielo.br/oai/scielo-oai.php||revista.arquivos@abneuro.org1678-42270004-282Xopendoar:2014-08-01T00:00Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologiafalse |
dc.title.none.fl_str_mv |
Sjögren syndrome and neuromyelitis optica spectrum disorder co-exist in a common autoimmune milieu |
title |
Sjögren syndrome and neuromyelitis optica spectrum disorder co-exist in a common autoimmune milieu |
spellingShingle |
Sjögren syndrome and neuromyelitis optica spectrum disorder co-exist in a common autoimmune milieu Carvalho,Diogo C. neuromyelitis optica spectrum disorders neuromyelitis optica Sjögren?s syndrome autoimmunity AQP4-IgG |
title_short |
Sjögren syndrome and neuromyelitis optica spectrum disorder co-exist in a common autoimmune milieu |
title_full |
Sjögren syndrome and neuromyelitis optica spectrum disorder co-exist in a common autoimmune milieu |
title_fullStr |
Sjögren syndrome and neuromyelitis optica spectrum disorder co-exist in a common autoimmune milieu |
title_full_unstemmed |
Sjögren syndrome and neuromyelitis optica spectrum disorder co-exist in a common autoimmune milieu |
title_sort |
Sjögren syndrome and neuromyelitis optica spectrum disorder co-exist in a common autoimmune milieu |
author |
Carvalho,Diogo C. |
author_facet |
Carvalho,Diogo C. Tironi,Tauana S. Freitas,Denise S. Kleinpaul,Rodrigo Talim,Natalia C. Lana-Peixoto,Marco A. |
author_role |
author |
author2 |
Tironi,Tauana S. Freitas,Denise S. Kleinpaul,Rodrigo Talim,Natalia C. Lana-Peixoto,Marco A. |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Carvalho,Diogo C. Tironi,Tauana S. Freitas,Denise S. Kleinpaul,Rodrigo Talim,Natalia C. Lana-Peixoto,Marco A. |
dc.subject.por.fl_str_mv |
neuromyelitis optica spectrum disorders neuromyelitis optica Sjögren?s syndrome autoimmunity AQP4-IgG |
topic |
neuromyelitis optica spectrum disorders neuromyelitis optica Sjögren?s syndrome autoimmunity AQP4-IgG |
description |
The relationship between Sjögren’s syndrome (SS) and neuromyelitis optica spectrum disorder (NMOSD) is not completely understood. We report two patients with both conditions and review 47 other previously reported cases meeting currently accepted diagnostic criteria, from 17 articles extracted from PubMed. Out of 44 patients whose gender was informed, 42 were females. Mean age at onset of neurological manifestation was 36.2 years (10-74). Serum anti-AQP4-IgG was positive in 32 patients, borderline in 1, and negative in 4. Our Case 1 was seronegative for AQP4-IgG and had no non-organ-specific autoantibodies other than anti-SSB antibodies. Our Case 2 had serum anti-AQP4, anti-SSA/SSB, anti-thyreoglobulin and anti-acethylcholine-receptor antibodies, as well as clinical hypothyreoidism, but no evidence of myasthenia gravis. Our Cases and others, as previously reported in literature, with similar heterogeneous autoimmune response to aquaporin-4, suggest that SS and NMO co-exist in a common autoimmune milieu which is not dependent on aquaporin-4 autoimmunity. |
publishDate |
2014 |
dc.date.none.fl_str_mv |
2014-08-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2014000800619 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2014000800619 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/0004-282X20140097 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Academia Brasileira de Neurologia - ABNEURO |
publisher.none.fl_str_mv |
Academia Brasileira de Neurologia - ABNEURO |
dc.source.none.fl_str_mv |
Arquivos de Neuro-Psiquiatria v.72 n.8 2014 reponame:Arquivos de neuro-psiquiatria (Online) instname:Academia Brasileira de Neurologia instacron:ABNEURO |
instname_str |
Academia Brasileira de Neurologia |
instacron_str |
ABNEURO |
institution |
ABNEURO |
reponame_str |
Arquivos de neuro-psiquiatria (Online) |
collection |
Arquivos de neuro-psiquiatria (Online) |
repository.name.fl_str_mv |
Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologia |
repository.mail.fl_str_mv |
||revista.arquivos@abneuro.org |
_version_ |
1754212776944861184 |