Circulating levels of neurotrophic factors are unchanged in patients with Parkinson's disease
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Arquivos de neuro-psiquiatria (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2018000500310 |
Resumo: | ABSTRACT There is great evidence linking neurotrophic factor (NF) dysfunction with Parkinson's disease (PD) pathophysiology. This study was conducted to evaluate plasma levels of NFs and their possible associations with clinical symptoms in PD. For this purpose, 40 PD patients and 25 controls were subjected to a clinical evaluation and peripheral blood draw. Plasma levels of brain-derived neurotrophic factor (BDNF), pro-BDNF, neurotrophin 3, neurotrophin 4, nerve growth, glial cell line-derived neurotrophic factor and ciliary neurotrophic factor were measured by enzyme-linked immunosorbent assay. There was no significant difference between PD patients and controls regarding the plasma levels of the evaluated NFs. In addition, NF levels were not associated with disease duration, degree of motor or functional impairment, cognitive performance or severity of depressive symptoms. In conclusion, although NFs may play relevant roles in the pathophysiology of PD, the circulating levels of these molecules are not necessarily changed in patients with PD. |
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Arquivos de neuro-psiquiatria (Online) |
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Circulating levels of neurotrophic factors are unchanged in patients with Parkinson's diseaseParkinson's diseasenerve growth factorsdepressionbiomarkerscognitionABSTRACT There is great evidence linking neurotrophic factor (NF) dysfunction with Parkinson's disease (PD) pathophysiology. This study was conducted to evaluate plasma levels of NFs and their possible associations with clinical symptoms in PD. For this purpose, 40 PD patients and 25 controls were subjected to a clinical evaluation and peripheral blood draw. Plasma levels of brain-derived neurotrophic factor (BDNF), pro-BDNF, neurotrophin 3, neurotrophin 4, nerve growth, glial cell line-derived neurotrophic factor and ciliary neurotrophic factor were measured by enzyme-linked immunosorbent assay. There was no significant difference between PD patients and controls regarding the plasma levels of the evaluated NFs. In addition, NF levels were not associated with disease duration, degree of motor or functional impairment, cognitive performance or severity of depressive symptoms. In conclusion, although NFs may play relevant roles in the pathophysiology of PD, the circulating levels of these molecules are not necessarily changed in patients with PD.Academia Brasileira de Neurologia - ABNEURO2018-05-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2018000500310Arquivos de Neuro-Psiquiatria v.76 n.5 2018reponame:Arquivos de neuro-psiquiatria (Online)instname:Academia Brasileira de Neurologiainstacron:ABNEURO10.1590/0004-282x20180035info:eu-repo/semantics/openAccessRocha,Natalia PessoaFerreira,João Paulo SampaioScalzo,Paula LucianaBarbosa,Izabela GuimarãesSouza,Mariana Soares deChristo,Paulo PereiraReis,Helton JoséTeixeira,Antonio Lucioeng2018-05-25T00:00:00Zoai:scielo:S0004-282X2018000500310Revistahttp://www.scielo.br/anphttps://old.scielo.br/oai/scielo-oai.php||revista.arquivos@abneuro.org1678-42270004-282Xopendoar:2018-05-25T00:00Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologiafalse |
dc.title.none.fl_str_mv |
Circulating levels of neurotrophic factors are unchanged in patients with Parkinson's disease |
title |
Circulating levels of neurotrophic factors are unchanged in patients with Parkinson's disease |
spellingShingle |
Circulating levels of neurotrophic factors are unchanged in patients with Parkinson's disease Rocha,Natalia Pessoa Parkinson's disease nerve growth factors depression biomarkers cognition |
title_short |
Circulating levels of neurotrophic factors are unchanged in patients with Parkinson's disease |
title_full |
Circulating levels of neurotrophic factors are unchanged in patients with Parkinson's disease |
title_fullStr |
Circulating levels of neurotrophic factors are unchanged in patients with Parkinson's disease |
title_full_unstemmed |
Circulating levels of neurotrophic factors are unchanged in patients with Parkinson's disease |
title_sort |
Circulating levels of neurotrophic factors are unchanged in patients with Parkinson's disease |
author |
Rocha,Natalia Pessoa |
author_facet |
Rocha,Natalia Pessoa Ferreira,João Paulo Sampaio Scalzo,Paula Luciana Barbosa,Izabela Guimarães Souza,Mariana Soares de Christo,Paulo Pereira Reis,Helton José Teixeira,Antonio Lucio |
author_role |
author |
author2 |
Ferreira,João Paulo Sampaio Scalzo,Paula Luciana Barbosa,Izabela Guimarães Souza,Mariana Soares de Christo,Paulo Pereira Reis,Helton José Teixeira,Antonio Lucio |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Rocha,Natalia Pessoa Ferreira,João Paulo Sampaio Scalzo,Paula Luciana Barbosa,Izabela Guimarães Souza,Mariana Soares de Christo,Paulo Pereira Reis,Helton José Teixeira,Antonio Lucio |
dc.subject.por.fl_str_mv |
Parkinson's disease nerve growth factors depression biomarkers cognition |
topic |
Parkinson's disease nerve growth factors depression biomarkers cognition |
description |
ABSTRACT There is great evidence linking neurotrophic factor (NF) dysfunction with Parkinson's disease (PD) pathophysiology. This study was conducted to evaluate plasma levels of NFs and their possible associations with clinical symptoms in PD. For this purpose, 40 PD patients and 25 controls were subjected to a clinical evaluation and peripheral blood draw. Plasma levels of brain-derived neurotrophic factor (BDNF), pro-BDNF, neurotrophin 3, neurotrophin 4, nerve growth, glial cell line-derived neurotrophic factor and ciliary neurotrophic factor were measured by enzyme-linked immunosorbent assay. There was no significant difference between PD patients and controls regarding the plasma levels of the evaluated NFs. In addition, NF levels were not associated with disease duration, degree of motor or functional impairment, cognitive performance or severity of depressive symptoms. In conclusion, although NFs may play relevant roles in the pathophysiology of PD, the circulating levels of these molecules are not necessarily changed in patients with PD. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-05-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2018000500310 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2018000500310 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/0004-282x20180035 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Academia Brasileira de Neurologia - ABNEURO |
publisher.none.fl_str_mv |
Academia Brasileira de Neurologia - ABNEURO |
dc.source.none.fl_str_mv |
Arquivos de Neuro-Psiquiatria v.76 n.5 2018 reponame:Arquivos de neuro-psiquiatria (Online) instname:Academia Brasileira de Neurologia instacron:ABNEURO |
instname_str |
Academia Brasileira de Neurologia |
instacron_str |
ABNEURO |
institution |
ABNEURO |
reponame_str |
Arquivos de neuro-psiquiatria (Online) |
collection |
Arquivos de neuro-psiquiatria (Online) |
repository.name.fl_str_mv |
Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologia |
repository.mail.fl_str_mv |
||revista.arquivos@abneuro.org |
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1754212783915794432 |