Low-grade astrocytoma: surgical outcomes in eloquent versus non-eloquent brain areas

Detalhes bibliográficos
Autor(a) principal: Bianco,André de Macedo
Data de Publicação: 2013
Outros Autores: Miura,Flavio Key, Clara,Carlos, Almeida,Jose Reynaldo W., Silva,Clemar Correa da, Teixeira,Manoel Jacobsen, Marie,Suely K. Nagahashi
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Arquivos de neuro-psiquiatria (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2013000100007
Resumo: A retrospective study of 81 patients with low-grade astrocytoma (LGA) comparing the efficacy of aggressive versus less aggressive surgery in eloquent and non-eloquent brain areas was conducted. Extent of surgical resection was analyzed to assess overall survival (OS) and progression- free survival (PFS). Degree of tumor resection was classified as gross total resection (GTR), subtotal resection (STR) or biopsy. GTR, STR and biopsy in patients with tumors in non-eloquent areas were performed in 31, 48 and 21% subjects, whereas in patients with tumors in eloquent areas resections were 22.5, 35 and 42.5%. Overall survival was 4.7 and 1.9 years in patients with tumors in non-eloquent brain areas submitted to GTR/STR and biopsy (p=0.013), whereas overall survival among patients with tumors in eloquent area was 4.5 and 2.1 years (p=0.33). Improved outcome for adult patients with LGA is predicted by more aggressive surgery in both eloquent and non-eloquent brain areas.
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spelling Low-grade astrocytoma: surgical outcomes in eloquent versus non-eloquent brain areasastrocytomasurvival analysisneurosurgeryA retrospective study of 81 patients with low-grade astrocytoma (LGA) comparing the efficacy of aggressive versus less aggressive surgery in eloquent and non-eloquent brain areas was conducted. Extent of surgical resection was analyzed to assess overall survival (OS) and progression- free survival (PFS). Degree of tumor resection was classified as gross total resection (GTR), subtotal resection (STR) or biopsy. GTR, STR and biopsy in patients with tumors in non-eloquent areas were performed in 31, 48 and 21% subjects, whereas in patients with tumors in eloquent areas resections were 22.5, 35 and 42.5%. Overall survival was 4.7 and 1.9 years in patients with tumors in non-eloquent brain areas submitted to GTR/STR and biopsy (p=0.013), whereas overall survival among patients with tumors in eloquent area was 4.5 and 2.1 years (p=0.33). Improved outcome for adult patients with LGA is predicted by more aggressive surgery in both eloquent and non-eloquent brain areas.Academia Brasileira de Neurologia - ABNEURO2013-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2013000100007Arquivos de Neuro-Psiquiatria v.71 n.1 2013reponame:Arquivos de neuro-psiquiatria (Online)instname:Academia Brasileira de Neurologiainstacron:ABNEURO10.1590/S0004-282X2012005000017info:eu-repo/semantics/openAccessBianco,André de MacedoMiura,Flavio KeyClara,CarlosAlmeida,Jose Reynaldo W.Silva,Clemar Correa daTeixeira,Manoel JacobsenMarie,Suely K. Nagahashieng2013-01-18T00:00:00Zoai:scielo:S0004-282X2013000100007Revistahttp://www.scielo.br/anphttps://old.scielo.br/oai/scielo-oai.php||revista.arquivos@abneuro.org1678-42270004-282Xopendoar:2013-01-18T00:00Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologiafalse
dc.title.none.fl_str_mv Low-grade astrocytoma: surgical outcomes in eloquent versus non-eloquent brain areas
title Low-grade astrocytoma: surgical outcomes in eloquent versus non-eloquent brain areas
spellingShingle Low-grade astrocytoma: surgical outcomes in eloquent versus non-eloquent brain areas
Bianco,André de Macedo
astrocytoma
survival analysis
neurosurgery
title_short Low-grade astrocytoma: surgical outcomes in eloquent versus non-eloquent brain areas
title_full Low-grade astrocytoma: surgical outcomes in eloquent versus non-eloquent brain areas
title_fullStr Low-grade astrocytoma: surgical outcomes in eloquent versus non-eloquent brain areas
title_full_unstemmed Low-grade astrocytoma: surgical outcomes in eloquent versus non-eloquent brain areas
title_sort Low-grade astrocytoma: surgical outcomes in eloquent versus non-eloquent brain areas
author Bianco,André de Macedo
author_facet Bianco,André de Macedo
Miura,Flavio Key
Clara,Carlos
Almeida,Jose Reynaldo W.
Silva,Clemar Correa da
Teixeira,Manoel Jacobsen
Marie,Suely K. Nagahashi
author_role author
author2 Miura,Flavio Key
Clara,Carlos
Almeida,Jose Reynaldo W.
Silva,Clemar Correa da
Teixeira,Manoel Jacobsen
Marie,Suely K. Nagahashi
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Bianco,André de Macedo
Miura,Flavio Key
Clara,Carlos
Almeida,Jose Reynaldo W.
Silva,Clemar Correa da
Teixeira,Manoel Jacobsen
Marie,Suely K. Nagahashi
dc.subject.por.fl_str_mv astrocytoma
survival analysis
neurosurgery
topic astrocytoma
survival analysis
neurosurgery
description A retrospective study of 81 patients with low-grade astrocytoma (LGA) comparing the efficacy of aggressive versus less aggressive surgery in eloquent and non-eloquent brain areas was conducted. Extent of surgical resection was analyzed to assess overall survival (OS) and progression- free survival (PFS). Degree of tumor resection was classified as gross total resection (GTR), subtotal resection (STR) or biopsy. GTR, STR and biopsy in patients with tumors in non-eloquent areas were performed in 31, 48 and 21% subjects, whereas in patients with tumors in eloquent areas resections were 22.5, 35 and 42.5%. Overall survival was 4.7 and 1.9 years in patients with tumors in non-eloquent brain areas submitted to GTR/STR and biopsy (p=0.013), whereas overall survival among patients with tumors in eloquent area was 4.5 and 2.1 years (p=0.33). Improved outcome for adult patients with LGA is predicted by more aggressive surgery in both eloquent and non-eloquent brain areas.
publishDate 2013
dc.date.none.fl_str_mv 2013-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2013000100007
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2013000100007
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0004-282X2012005000017
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Academia Brasileira de Neurologia - ABNEURO
publisher.none.fl_str_mv Academia Brasileira de Neurologia - ABNEURO
dc.source.none.fl_str_mv Arquivos de Neuro-Psiquiatria v.71 n.1 2013
reponame:Arquivos de neuro-psiquiatria (Online)
instname:Academia Brasileira de Neurologia
instacron:ABNEURO
instname_str Academia Brasileira de Neurologia
instacron_str ABNEURO
institution ABNEURO
reponame_str Arquivos de neuro-psiquiatria (Online)
collection Arquivos de neuro-psiquiatria (Online)
repository.name.fl_str_mv Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologia
repository.mail.fl_str_mv ||revista.arquivos@abneuro.org
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