Effects of misoprostrol on pentylenetetrazol-induced seizures in mice
Autor(a) principal: | |
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Data de Publicação: | 1997 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Arquivos de neuro-psiquiatria (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X1997000500001 |
Resumo: | The effects of prostaglandin E - analogue misoprostol on the susceptibility to pentilenetetrazol(PTZ) - induced seizures were examined in mice. Misoprostol (200-800 mg/kg), given subcutaneously 45 min before the subconvulsive dose of PTZ (30 mg/kg, i.p) provoked dose-dependent clonic-tonic seizures (30 to 100%) and mortality in mice. At 300 g/kg, s.c, misoprostol pretreatment significantly (p<0.05) lowered the onset latency to first convulsion as well as the latency to mortality induced by a convulsive dose of PTZ (60 mg/kg, i.p.). At this dose misoprostol was found to lower the CD50 and Ld50 values for PTZ by 21 % and 36% respectively. The results suggest that prostaglandins are likely to lower the threshold for convulsions. |
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Effects of misoprostrol on pentylenetetrazol-induced seizures in miceseizurespentylenetetrazolmisoprostolmiceThe effects of prostaglandin E - analogue misoprostol on the susceptibility to pentilenetetrazol(PTZ) - induced seizures were examined in mice. Misoprostol (200-800 mg/kg), given subcutaneously 45 min before the subconvulsive dose of PTZ (30 mg/kg, i.p) provoked dose-dependent clonic-tonic seizures (30 to 100%) and mortality in mice. At 300 g/kg, s.c, misoprostol pretreatment significantly (p<0.05) lowered the onset latency to first convulsion as well as the latency to mortality induced by a convulsive dose of PTZ (60 mg/kg, i.p.). At this dose misoprostol was found to lower the CD50 and Ld50 values for PTZ by 21 % and 36% respectively. The results suggest that prostaglandins are likely to lower the threshold for convulsions.Academia Brasileira de Neurologia - ABNEURO1997-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X1997000500001Arquivos de Neuro-Psiquiatria v.55 n.4 1997reponame:Arquivos de neuro-psiquiatria (Online)instname:Academia Brasileira de Neurologiainstacron:ABNEURO10.1590/S0004-282X1997000500001info:eu-repo/semantics/openAccessMedeiros,Francisco das ChagasMedeiros,Maria AngelinaRao,Vietla SatyanaraynaFigueiredo,Eberval Gadelhaeng2010-10-21T00:00:00Zoai:scielo:S0004-282X1997000500001Revistahttp://www.scielo.br/anphttps://old.scielo.br/oai/scielo-oai.php||revista.arquivos@abneuro.org1678-42270004-282Xopendoar:2010-10-21T00:00Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologiafalse |
dc.title.none.fl_str_mv |
Effects of misoprostrol on pentylenetetrazol-induced seizures in mice |
title |
Effects of misoprostrol on pentylenetetrazol-induced seizures in mice |
spellingShingle |
Effects of misoprostrol on pentylenetetrazol-induced seizures in mice Medeiros,Francisco das Chagas seizures pentylenetetrazol misoprostol mice |
title_short |
Effects of misoprostrol on pentylenetetrazol-induced seizures in mice |
title_full |
Effects of misoprostrol on pentylenetetrazol-induced seizures in mice |
title_fullStr |
Effects of misoprostrol on pentylenetetrazol-induced seizures in mice |
title_full_unstemmed |
Effects of misoprostrol on pentylenetetrazol-induced seizures in mice |
title_sort |
Effects of misoprostrol on pentylenetetrazol-induced seizures in mice |
author |
Medeiros,Francisco das Chagas |
author_facet |
Medeiros,Francisco das Chagas Medeiros,Maria Angelina Rao,Vietla Satyanarayna Figueiredo,Eberval Gadelha |
author_role |
author |
author2 |
Medeiros,Maria Angelina Rao,Vietla Satyanarayna Figueiredo,Eberval Gadelha |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Medeiros,Francisco das Chagas Medeiros,Maria Angelina Rao,Vietla Satyanarayna Figueiredo,Eberval Gadelha |
dc.subject.por.fl_str_mv |
seizures pentylenetetrazol misoprostol mice |
topic |
seizures pentylenetetrazol misoprostol mice |
description |
The effects of prostaglandin E - analogue misoprostol on the susceptibility to pentilenetetrazol(PTZ) - induced seizures were examined in mice. Misoprostol (200-800 mg/kg), given subcutaneously 45 min before the subconvulsive dose of PTZ (30 mg/kg, i.p) provoked dose-dependent clonic-tonic seizures (30 to 100%) and mortality in mice. At 300 g/kg, s.c, misoprostol pretreatment significantly (p<0.05) lowered the onset latency to first convulsion as well as the latency to mortality induced by a convulsive dose of PTZ (60 mg/kg, i.p.). At this dose misoprostol was found to lower the CD50 and Ld50 values for PTZ by 21 % and 36% respectively. The results suggest that prostaglandins are likely to lower the threshold for convulsions. |
publishDate |
1997 |
dc.date.none.fl_str_mv |
1997-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X1997000500001 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X1997000500001 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0004-282X1997000500001 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Academia Brasileira de Neurologia - ABNEURO |
publisher.none.fl_str_mv |
Academia Brasileira de Neurologia - ABNEURO |
dc.source.none.fl_str_mv |
Arquivos de Neuro-Psiquiatria v.55 n.4 1997 reponame:Arquivos de neuro-psiquiatria (Online) instname:Academia Brasileira de Neurologia instacron:ABNEURO |
instname_str |
Academia Brasileira de Neurologia |
instacron_str |
ABNEURO |
institution |
ABNEURO |
reponame_str |
Arquivos de neuro-psiquiatria (Online) |
collection |
Arquivos de neuro-psiquiatria (Online) |
repository.name.fl_str_mv |
Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologia |
repository.mail.fl_str_mv |
||revista.arquivos@abneuro.org |
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1754212750470414336 |