C3c intrathecal synthesis evaluation in patients with multiple sclerosis
Autor(a) principal: | |
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Data de Publicação: | 2007 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Arquivos de neuro-psiquiatria (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2007000500013 |
Resumo: | INTRODUCTION: Multiple sclerosis (MS) is a chronic, inflammatory and progressive disease of the central nervous system in which local inflammatory injuries of the brain white matter appears, being the most outstanding feature the myeline loss (demyelination). OBJECTIVE: To determine if the complement system might be involved in the MS immunopathogeny favouring the mechanism intervening in the myelin destruction. METHOD: Samples of sera and CSF from twelve patients with a diagnosis of MS obtained at the moment of the admission to the hospital at the beginning of the break out, were collected. Levels of C3c and albumin in sera and in CSF were quantified using radial immunodiffusion plates. RESULTS: High values over 80% of intrathecal synthesis were obtained except in one of the patients. CONCLUSION: Intrathecal synthesis of C3c and its liberation to the CSF means that the activation of the complement system in any of the two ways has taken place, and that once performed its biological functions, has suffered a degradation process. |
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Arquivos de neuro-psiquiatria (Online) |
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C3c intrathecal synthesis evaluation in patients with multiple sclerosiscytotoxicitycomplementmultiple sclerosishypersensibilityimmunopathogenicityreibergramINTRODUCTION: Multiple sclerosis (MS) is a chronic, inflammatory and progressive disease of the central nervous system in which local inflammatory injuries of the brain white matter appears, being the most outstanding feature the myeline loss (demyelination). OBJECTIVE: To determine if the complement system might be involved in the MS immunopathogeny favouring the mechanism intervening in the myelin destruction. METHOD: Samples of sera and CSF from twelve patients with a diagnosis of MS obtained at the moment of the admission to the hospital at the beginning of the break out, were collected. Levels of C3c and albumin in sera and in CSF were quantified using radial immunodiffusion plates. RESULTS: High values over 80% of intrathecal synthesis were obtained except in one of the patients. CONCLUSION: Intrathecal synthesis of C3c and its liberation to the CSF means that the activation of the complement system in any of the two ways has taken place, and that once performed its biological functions, has suffered a degradation process.Academia Brasileira de Neurologia - ABNEURO2007-09-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2007000500013Arquivos de Neuro-Psiquiatria v.65 n.3b 2007reponame:Arquivos de neuro-psiquiatria (Online)instname:Academia Brasileira de Neurologiainstacron:ABNEURO10.1590/S0004-282X2007000500013info:eu-repo/semantics/openAccessPadilla-Docal,BárbaraDorta-Contreras,Alberto JFundora-Hernández,HermesNoris-García,ElenaBu-Coifiu-Fanego,RaisaGonzález-Hernández,MarlenRodríguez-Rey,Alexiseng2008-04-11T00:00:00Zoai:scielo:S0004-282X2007000500013Revistahttp://www.scielo.br/anphttps://old.scielo.br/oai/scielo-oai.php||revista.arquivos@abneuro.org1678-42270004-282Xopendoar:2008-04-11T00:00Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologiafalse |
dc.title.none.fl_str_mv |
C3c intrathecal synthesis evaluation in patients with multiple sclerosis |
title |
C3c intrathecal synthesis evaluation in patients with multiple sclerosis |
spellingShingle |
C3c intrathecal synthesis evaluation in patients with multiple sclerosis Padilla-Docal,Bárbara cytotoxicity complement multiple sclerosis hypersensibility immunopathogenicity reibergram |
title_short |
C3c intrathecal synthesis evaluation in patients with multiple sclerosis |
title_full |
C3c intrathecal synthesis evaluation in patients with multiple sclerosis |
title_fullStr |
C3c intrathecal synthesis evaluation in patients with multiple sclerosis |
title_full_unstemmed |
C3c intrathecal synthesis evaluation in patients with multiple sclerosis |
title_sort |
C3c intrathecal synthesis evaluation in patients with multiple sclerosis |
author |
Padilla-Docal,Bárbara |
author_facet |
Padilla-Docal,Bárbara Dorta-Contreras,Alberto J Fundora-Hernández,Hermes Noris-García,Elena Bu-Coifiu-Fanego,Raisa González-Hernández,Marlen Rodríguez-Rey,Alexis |
author_role |
author |
author2 |
Dorta-Contreras,Alberto J Fundora-Hernández,Hermes Noris-García,Elena Bu-Coifiu-Fanego,Raisa González-Hernández,Marlen Rodríguez-Rey,Alexis |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Padilla-Docal,Bárbara Dorta-Contreras,Alberto J Fundora-Hernández,Hermes Noris-García,Elena Bu-Coifiu-Fanego,Raisa González-Hernández,Marlen Rodríguez-Rey,Alexis |
dc.subject.por.fl_str_mv |
cytotoxicity complement multiple sclerosis hypersensibility immunopathogenicity reibergram |
topic |
cytotoxicity complement multiple sclerosis hypersensibility immunopathogenicity reibergram |
description |
INTRODUCTION: Multiple sclerosis (MS) is a chronic, inflammatory and progressive disease of the central nervous system in which local inflammatory injuries of the brain white matter appears, being the most outstanding feature the myeline loss (demyelination). OBJECTIVE: To determine if the complement system might be involved in the MS immunopathogeny favouring the mechanism intervening in the myelin destruction. METHOD: Samples of sera and CSF from twelve patients with a diagnosis of MS obtained at the moment of the admission to the hospital at the beginning of the break out, were collected. Levels of C3c and albumin in sera and in CSF were quantified using radial immunodiffusion plates. RESULTS: High values over 80% of intrathecal synthesis were obtained except in one of the patients. CONCLUSION: Intrathecal synthesis of C3c and its liberation to the CSF means that the activation of the complement system in any of the two ways has taken place, and that once performed its biological functions, has suffered a degradation process. |
publishDate |
2007 |
dc.date.none.fl_str_mv |
2007-09-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2007000500013 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2007000500013 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0004-282X2007000500013 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Academia Brasileira de Neurologia - ABNEURO |
publisher.none.fl_str_mv |
Academia Brasileira de Neurologia - ABNEURO |
dc.source.none.fl_str_mv |
Arquivos de Neuro-Psiquiatria v.65 n.3b 2007 reponame:Arquivos de neuro-psiquiatria (Online) instname:Academia Brasileira de Neurologia instacron:ABNEURO |
instname_str |
Academia Brasileira de Neurologia |
instacron_str |
ABNEURO |
institution |
ABNEURO |
reponame_str |
Arquivos de neuro-psiquiatria (Online) |
collection |
Arquivos de neuro-psiquiatria (Online) |
repository.name.fl_str_mv |
Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologia |
repository.mail.fl_str_mv |
||revista.arquivos@abneuro.org |
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1754212762228097024 |