Pure neural leprosy: steroids prevent neuropathy progression

Detalhes bibliográficos
Autor(a) principal: Jardim,Márcia R.
Data de Publicação: 2007
Outros Autores: Illarramendi,Ximena, Nascimento,Osvaldo J.M., Nery,Jose Augusto C., Sales,Anna M., Sampaio,Elizabeth P., Sarno,Euzenir N.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Arquivos de neuro-psiquiatria (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2007000600009
Resumo: Multidrug therapy (MDT), with rifampicin, dapsone, and clofazimine, treats leprosy infection but is insufficient in arresting or preventing the nerve damage that causes impairments and disabilities. This case-series study evaluates the benefits of the combined use of steroids and MDT in preventing nerve damage in patients with pure neural leprosy (PNL). In addition to MDT, 24 patients (88% male aged 20-79 years, median=41) received a daily morning dose of 60 mg prednisone (PDN) that was gradually reduced by 10 mg during each of the following 5 months. PNL was clinically diagnosed and confirmed by nerve histopathology or PCR. A low prevalence (8.3%) of reaction was observed after release from treatment. However, most of the clinical parameters showed significant improvement; and a reduction of nerve conduction block was observed in 42% of the patients. The administration of full-dose PDN improved the clinical and electrophysiological condition of the PNL patients, contributing to the prevention of further neurological damage.
id ABNEURO-1_791a3c9fabb856fae4c349e197d9a0c4
oai_identifier_str oai:scielo:S0004-282X2007000600009
network_acronym_str ABNEURO-1
network_name_str Arquivos de neuro-psiquiatria (Online)
repository_id_str
spelling Pure neural leprosy: steroids prevent neuropathy progressionperipheral neuropathypure neural leprosysteroidsMultidrug therapy (MDT), with rifampicin, dapsone, and clofazimine, treats leprosy infection but is insufficient in arresting or preventing the nerve damage that causes impairments and disabilities. This case-series study evaluates the benefits of the combined use of steroids and MDT in preventing nerve damage in patients with pure neural leprosy (PNL). In addition to MDT, 24 patients (88% male aged 20-79 years, median=41) received a daily morning dose of 60 mg prednisone (PDN) that was gradually reduced by 10 mg during each of the following 5 months. PNL was clinically diagnosed and confirmed by nerve histopathology or PCR. A low prevalence (8.3%) of reaction was observed after release from treatment. However, most of the clinical parameters showed significant improvement; and a reduction of nerve conduction block was observed in 42% of the patients. The administration of full-dose PDN improved the clinical and electrophysiological condition of the PNL patients, contributing to the prevention of further neurological damage.Academia Brasileira de Neurologia - ABNEURO2007-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2007000600009Arquivos de Neuro-Psiquiatria v.65 n.4a 2007reponame:Arquivos de neuro-psiquiatria (Online)instname:Academia Brasileira de Neurologiainstacron:ABNEURO10.1590/S0004-282X2007000600009info:eu-repo/semantics/openAccessJardim,Márcia R.Illarramendi,XimenaNascimento,Osvaldo J.M.Nery,Jose Augusto C.Sales,Anna M.Sampaio,Elizabeth P.Sarno,Euzenir N.eng2007-12-06T00:00:00Zoai:scielo:S0004-282X2007000600009Revistahttp://www.scielo.br/anphttps://old.scielo.br/oai/scielo-oai.php||revista.arquivos@abneuro.org1678-42270004-282Xopendoar:2007-12-06T00:00Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologiafalse
dc.title.none.fl_str_mv Pure neural leprosy: steroids prevent neuropathy progression
title Pure neural leprosy: steroids prevent neuropathy progression
spellingShingle Pure neural leprosy: steroids prevent neuropathy progression
Jardim,Márcia R.
peripheral neuropathy
pure neural leprosy
steroids
title_short Pure neural leprosy: steroids prevent neuropathy progression
title_full Pure neural leprosy: steroids prevent neuropathy progression
title_fullStr Pure neural leprosy: steroids prevent neuropathy progression
title_full_unstemmed Pure neural leprosy: steroids prevent neuropathy progression
title_sort Pure neural leprosy: steroids prevent neuropathy progression
author Jardim,Márcia R.
author_facet Jardim,Márcia R.
Illarramendi,Ximena
Nascimento,Osvaldo J.M.
Nery,Jose Augusto C.
Sales,Anna M.
Sampaio,Elizabeth P.
Sarno,Euzenir N.
author_role author
author2 Illarramendi,Ximena
Nascimento,Osvaldo J.M.
Nery,Jose Augusto C.
Sales,Anna M.
Sampaio,Elizabeth P.
Sarno,Euzenir N.
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Jardim,Márcia R.
Illarramendi,Ximena
Nascimento,Osvaldo J.M.
Nery,Jose Augusto C.
Sales,Anna M.
Sampaio,Elizabeth P.
Sarno,Euzenir N.
dc.subject.por.fl_str_mv peripheral neuropathy
pure neural leprosy
steroids
topic peripheral neuropathy
pure neural leprosy
steroids
description Multidrug therapy (MDT), with rifampicin, dapsone, and clofazimine, treats leprosy infection but is insufficient in arresting or preventing the nerve damage that causes impairments and disabilities. This case-series study evaluates the benefits of the combined use of steroids and MDT in preventing nerve damage in patients with pure neural leprosy (PNL). In addition to MDT, 24 patients (88% male aged 20-79 years, median=41) received a daily morning dose of 60 mg prednisone (PDN) that was gradually reduced by 10 mg during each of the following 5 months. PNL was clinically diagnosed and confirmed by nerve histopathology or PCR. A low prevalence (8.3%) of reaction was observed after release from treatment. However, most of the clinical parameters showed significant improvement; and a reduction of nerve conduction block was observed in 42% of the patients. The administration of full-dose PDN improved the clinical and electrophysiological condition of the PNL patients, contributing to the prevention of further neurological damage.
publishDate 2007
dc.date.none.fl_str_mv 2007-12-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2007000600009
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2007000600009
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0004-282X2007000600009
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Academia Brasileira de Neurologia - ABNEURO
publisher.none.fl_str_mv Academia Brasileira de Neurologia - ABNEURO
dc.source.none.fl_str_mv Arquivos de Neuro-Psiquiatria v.65 n.4a 2007
reponame:Arquivos de neuro-psiquiatria (Online)
instname:Academia Brasileira de Neurologia
instacron:ABNEURO
instname_str Academia Brasileira de Neurologia
instacron_str ABNEURO
institution ABNEURO
reponame_str Arquivos de neuro-psiquiatria (Online)
collection Arquivos de neuro-psiquiatria (Online)
repository.name.fl_str_mv Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologia
repository.mail.fl_str_mv ||revista.arquivos@abneuro.org
_version_ 1754212762698907648