Ultrastructure of cranial nerves of rats inoculated with rabies virus
Autor(a) principal: | |
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Data de Publicação: | 1997 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Arquivos de neuro-psiquiatria (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X1997000500002 |
Resumo: | The V and VII cranial nerves of rats inoculated with rabies virus were studied by electron microscopy. The results were compared with the same cranial nerves of rats inoculated with rabies virus but vaccinated against the disease. The findings are those of axonal degeneration and intense demyelination of the nerves of the group of rats not vaccinated. The vaccinated rats showed some ultrastructural irrelevant alterations when compared with the other group. The degree of ultrastructural alterations found in the group of rats not vaccinated suggests that in rabies severe damage of the cranial nerves occurs and that this may be closely related to the clinical picture of the disease (hydrophobia). Furthermore, as far as the authors know, this has not been considered in the classic descriptions of rabies and it is possible that an immunologic process may take part in the demyelination observed in the present study. |
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Arquivos de neuro-psiquiatria (Online) |
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Ultrastructure of cranial nerves of rats inoculated with rabies virusrabiescranial nerveselectron microscopyThe V and VII cranial nerves of rats inoculated with rabies virus were studied by electron microscopy. The results were compared with the same cranial nerves of rats inoculated with rabies virus but vaccinated against the disease. The findings are those of axonal degeneration and intense demyelination of the nerves of the group of rats not vaccinated. The vaccinated rats showed some ultrastructural irrelevant alterations when compared with the other group. The degree of ultrastructural alterations found in the group of rats not vaccinated suggests that in rabies severe damage of the cranial nerves occurs and that this may be closely related to the clinical picture of the disease (hydrophobia). Furthermore, as far as the authors know, this has not been considered in the classic descriptions of rabies and it is possible that an immunologic process may take part in the demyelination observed in the present study.Academia Brasileira de Neurologia - ABNEURO1997-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X1997000500002Arquivos de Neuro-Psiquiatria v.55 n.4 1997reponame:Arquivos de neuro-psiquiatria (Online)instname:Academia Brasileira de Neurologiainstacron:ABNEURO10.1590/S0004-282X1997000500002info:eu-repo/semantics/openAccessMinguetti,GuilbertoHofmeister,Robin M.Hayashi,YasuyoshiMontaño,Juan A.eng2010-10-07T00:00:00Zoai:scielo:S0004-282X1997000500002Revistahttp://www.scielo.br/anphttps://old.scielo.br/oai/scielo-oai.php||revista.arquivos@abneuro.org1678-42270004-282Xopendoar:2010-10-07T00:00Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologiafalse |
dc.title.none.fl_str_mv |
Ultrastructure of cranial nerves of rats inoculated with rabies virus |
title |
Ultrastructure of cranial nerves of rats inoculated with rabies virus |
spellingShingle |
Ultrastructure of cranial nerves of rats inoculated with rabies virus Minguetti,Guilberto rabies cranial nerves electron microscopy |
title_short |
Ultrastructure of cranial nerves of rats inoculated with rabies virus |
title_full |
Ultrastructure of cranial nerves of rats inoculated with rabies virus |
title_fullStr |
Ultrastructure of cranial nerves of rats inoculated with rabies virus |
title_full_unstemmed |
Ultrastructure of cranial nerves of rats inoculated with rabies virus |
title_sort |
Ultrastructure of cranial nerves of rats inoculated with rabies virus |
author |
Minguetti,Guilberto |
author_facet |
Minguetti,Guilberto Hofmeister,Robin M. Hayashi,Yasuyoshi Montaño,Juan A. |
author_role |
author |
author2 |
Hofmeister,Robin M. Hayashi,Yasuyoshi Montaño,Juan A. |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Minguetti,Guilberto Hofmeister,Robin M. Hayashi,Yasuyoshi Montaño,Juan A. |
dc.subject.por.fl_str_mv |
rabies cranial nerves electron microscopy |
topic |
rabies cranial nerves electron microscopy |
description |
The V and VII cranial nerves of rats inoculated with rabies virus were studied by electron microscopy. The results were compared with the same cranial nerves of rats inoculated with rabies virus but vaccinated against the disease. The findings are those of axonal degeneration and intense demyelination of the nerves of the group of rats not vaccinated. The vaccinated rats showed some ultrastructural irrelevant alterations when compared with the other group. The degree of ultrastructural alterations found in the group of rats not vaccinated suggests that in rabies severe damage of the cranial nerves occurs and that this may be closely related to the clinical picture of the disease (hydrophobia). Furthermore, as far as the authors know, this has not been considered in the classic descriptions of rabies and it is possible that an immunologic process may take part in the demyelination observed in the present study. |
publishDate |
1997 |
dc.date.none.fl_str_mv |
1997-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X1997000500002 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X1997000500002 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0004-282X1997000500002 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Academia Brasileira de Neurologia - ABNEURO |
publisher.none.fl_str_mv |
Academia Brasileira de Neurologia - ABNEURO |
dc.source.none.fl_str_mv |
Arquivos de Neuro-Psiquiatria v.55 n.4 1997 reponame:Arquivos de neuro-psiquiatria (Online) instname:Academia Brasileira de Neurologia instacron:ABNEURO |
instname_str |
Academia Brasileira de Neurologia |
instacron_str |
ABNEURO |
institution |
ABNEURO |
reponame_str |
Arquivos de neuro-psiquiatria (Online) |
collection |
Arquivos de neuro-psiquiatria (Online) |
repository.name.fl_str_mv |
Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologia |
repository.mail.fl_str_mv |
||revista.arquivos@abneuro.org |
_version_ |
1754212750472511488 |