Neurosyphilis and ocular syphilis clinical and cerebrospinal fluid characteristics: a case series
Autor(a) principal: | |
---|---|
Data de Publicação: | 2018 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Arquivos de neuro-psiquiatria (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2018000600373 |
Resumo: | ABSTRACT Background During the first decade of this century, a significant increase in the incidence of syphilis was documented. Objective To study clinical and laboratory characteristics of central nervous system and ocular syphilis. Methods A retrospective case series of 13 patients with a clinical and laboratory diagnosis of neurosyphilis and/or ocular syphilis who had been admitted to the Neurology and Neuro-ophthalmology Service of the Hospital de Clínicas, Federal University of Paraná. Results Nine patients had a diagnosis of neurosyphilis and two of them also had ocular syphilis. Four patients had a diagnosis of ocular syphilis alone. Among the patients with a diagnosis of neurosyphilis, six had symptomatic syphilitic meningitis, of whom one manifested as cranial nerve palsy alone, one as cranial nerve palsy plus ocular syphilis, two as transverse myelitis (syphilitic meningomyelitis), one as meningitis worsening the patient’s myasthenia gravis symptoms and one as meningitis plus ocular syphilis. Additionally, we diagnosed three patients with meningovascular neurosyphilis. In the univariate analysis, patients without ocular syphilis showed greater levels of total protein and white blood cells in the cerebrospinal fluid than patients with ocular syphilis. Conclusion This Brazilian case series of patients with neurosyphilis and ocular syphilis highlights the wide variability of this disease. A high degree of diagnostic suspicion is necessary when facing neurological and ocular symptoms for rapid diagnosis and appropriate management of patients. |
id |
ABNEURO-1_9c1ff01acb2f59a2e148414fef8543f2 |
---|---|
oai_identifier_str |
oai:scielo:S0004-282X2018000600373 |
network_acronym_str |
ABNEURO-1 |
network_name_str |
Arquivos de neuro-psiquiatria (Online) |
repository_id_str |
|
spelling |
Neurosyphilis and ocular syphilis clinical and cerebrospinal fluid characteristics: a case seriessyphilisneurosyphilis, ocular syphilisABSTRACT Background During the first decade of this century, a significant increase in the incidence of syphilis was documented. Objective To study clinical and laboratory characteristics of central nervous system and ocular syphilis. Methods A retrospective case series of 13 patients with a clinical and laboratory diagnosis of neurosyphilis and/or ocular syphilis who had been admitted to the Neurology and Neuro-ophthalmology Service of the Hospital de Clínicas, Federal University of Paraná. Results Nine patients had a diagnosis of neurosyphilis and two of them also had ocular syphilis. Four patients had a diagnosis of ocular syphilis alone. Among the patients with a diagnosis of neurosyphilis, six had symptomatic syphilitic meningitis, of whom one manifested as cranial nerve palsy alone, one as cranial nerve palsy plus ocular syphilis, two as transverse myelitis (syphilitic meningomyelitis), one as meningitis worsening the patient’s myasthenia gravis symptoms and one as meningitis plus ocular syphilis. Additionally, we diagnosed three patients with meningovascular neurosyphilis. In the univariate analysis, patients without ocular syphilis showed greater levels of total protein and white blood cells in the cerebrospinal fluid than patients with ocular syphilis. Conclusion This Brazilian case series of patients with neurosyphilis and ocular syphilis highlights the wide variability of this disease. A high degree of diagnostic suspicion is necessary when facing neurological and ocular symptoms for rapid diagnosis and appropriate management of patients.Academia Brasileira de Neurologia - ABNEURO2018-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2018000600373Arquivos de Neuro-Psiquiatria v.76 n.6 2018reponame:Arquivos de neuro-psiquiatria (Online)instname:Academia Brasileira de Neurologiainstacron:ABNEURO10.1590/0004-282x20180054info:eu-repo/semantics/openAccessBorges,Conrado RegisAlmeida,Sérgio Monteiro deSue,KarenKoslyk,Jéssyca Luana AlvesSato,Mario TeruoShiokawa,NaoyeTeive,Hélio Afonso Ghizonieng2018-06-26T00:00:00Zoai:scielo:S0004-282X2018000600373Revistahttp://www.scielo.br/anphttps://old.scielo.br/oai/scielo-oai.php||revista.arquivos@abneuro.org1678-42270004-282Xopendoar:2018-06-26T00:00Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologiafalse |
dc.title.none.fl_str_mv |
Neurosyphilis and ocular syphilis clinical and cerebrospinal fluid characteristics: a case series |
title |
Neurosyphilis and ocular syphilis clinical and cerebrospinal fluid characteristics: a case series |
spellingShingle |
Neurosyphilis and ocular syphilis clinical and cerebrospinal fluid characteristics: a case series Borges,Conrado Regis syphilis neurosyphilis, ocular syphilis |
title_short |
Neurosyphilis and ocular syphilis clinical and cerebrospinal fluid characteristics: a case series |
title_full |
Neurosyphilis and ocular syphilis clinical and cerebrospinal fluid characteristics: a case series |
title_fullStr |
Neurosyphilis and ocular syphilis clinical and cerebrospinal fluid characteristics: a case series |
title_full_unstemmed |
Neurosyphilis and ocular syphilis clinical and cerebrospinal fluid characteristics: a case series |
title_sort |
Neurosyphilis and ocular syphilis clinical and cerebrospinal fluid characteristics: a case series |
author |
Borges,Conrado Regis |
author_facet |
Borges,Conrado Regis Almeida,Sérgio Monteiro de Sue,Karen Koslyk,Jéssyca Luana Alves Sato,Mario Teruo Shiokawa,Naoye Teive,Hélio Afonso Ghizoni |
author_role |
author |
author2 |
Almeida,Sérgio Monteiro de Sue,Karen Koslyk,Jéssyca Luana Alves Sato,Mario Teruo Shiokawa,Naoye Teive,Hélio Afonso Ghizoni |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Borges,Conrado Regis Almeida,Sérgio Monteiro de Sue,Karen Koslyk,Jéssyca Luana Alves Sato,Mario Teruo Shiokawa,Naoye Teive,Hélio Afonso Ghizoni |
dc.subject.por.fl_str_mv |
syphilis neurosyphilis, ocular syphilis |
topic |
syphilis neurosyphilis, ocular syphilis |
description |
ABSTRACT Background During the first decade of this century, a significant increase in the incidence of syphilis was documented. Objective To study clinical and laboratory characteristics of central nervous system and ocular syphilis. Methods A retrospective case series of 13 patients with a clinical and laboratory diagnosis of neurosyphilis and/or ocular syphilis who had been admitted to the Neurology and Neuro-ophthalmology Service of the Hospital de Clínicas, Federal University of Paraná. Results Nine patients had a diagnosis of neurosyphilis and two of them also had ocular syphilis. Four patients had a diagnosis of ocular syphilis alone. Among the patients with a diagnosis of neurosyphilis, six had symptomatic syphilitic meningitis, of whom one manifested as cranial nerve palsy alone, one as cranial nerve palsy plus ocular syphilis, two as transverse myelitis (syphilitic meningomyelitis), one as meningitis worsening the patient’s myasthenia gravis symptoms and one as meningitis plus ocular syphilis. Additionally, we diagnosed three patients with meningovascular neurosyphilis. In the univariate analysis, patients without ocular syphilis showed greater levels of total protein and white blood cells in the cerebrospinal fluid than patients with ocular syphilis. Conclusion This Brazilian case series of patients with neurosyphilis and ocular syphilis highlights the wide variability of this disease. A high degree of diagnostic suspicion is necessary when facing neurological and ocular symptoms for rapid diagnosis and appropriate management of patients. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-06-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2018000600373 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2018000600373 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/0004-282x20180054 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Academia Brasileira de Neurologia - ABNEURO |
publisher.none.fl_str_mv |
Academia Brasileira de Neurologia - ABNEURO |
dc.source.none.fl_str_mv |
Arquivos de Neuro-Psiquiatria v.76 n.6 2018 reponame:Arquivos de neuro-psiquiatria (Online) instname:Academia Brasileira de Neurologia instacron:ABNEURO |
instname_str |
Academia Brasileira de Neurologia |
instacron_str |
ABNEURO |
institution |
ABNEURO |
reponame_str |
Arquivos de neuro-psiquiatria (Online) |
collection |
Arquivos de neuro-psiquiatria (Online) |
repository.name.fl_str_mv |
Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologia |
repository.mail.fl_str_mv |
||revista.arquivos@abneuro.org |
_version_ |
1754212783968223232 |