Seronegative Neuromyelitis Optica Spectrum - The challenges on disease definition and pathogenesis
Autor(a) principal: | |
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Data de Publicação: | 2014 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Arquivos de neuro-psiquiatria (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2014000600445 |
Resumo: | Neuromyelitis optica spectrum disorders (NMOSD) are characterized by severe optic neuritis and/or longitudinally extensive transverse myelitis, and some brain lesions are also unique to NMOSD. Serum autoantibodies against aquaporin-4 (AQP4) are detected in most cases of NMOSD. However, some patients with NMOSD remain seronegative despite repetitive testing during attacks with highly sensitive cell-based assays. The differential diagnosis of NMOSD is not restricted to multiple sclerosis and it includes many diseases that can produce longitudinally extensive myelitis and/or optic neuritis. We review the clinical features, imaging, and laboratory findings that can be helpful on the diagnostic work-up, discuss the differences between AQP4 antibody positive and negative patients with NMOSD, including features of NMOSD with antibodies against myelin oligodendrocyte glycoprotein. |
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Seronegative Neuromyelitis Optica Spectrum - The challenges on disease definition and pathogenesisneuromyelitis opticaaquaporin-4myelin oligodendrocyte glycoproteinantibodymyelitisoptic neuritisdifferential diagnosisNeuromyelitis optica spectrum disorders (NMOSD) are characterized by severe optic neuritis and/or longitudinally extensive transverse myelitis, and some brain lesions are also unique to NMOSD. Serum autoantibodies against aquaporin-4 (AQP4) are detected in most cases of NMOSD. However, some patients with NMOSD remain seronegative despite repetitive testing during attacks with highly sensitive cell-based assays. The differential diagnosis of NMOSD is not restricted to multiple sclerosis and it includes many diseases that can produce longitudinally extensive myelitis and/or optic neuritis. We review the clinical features, imaging, and laboratory findings that can be helpful on the diagnostic work-up, discuss the differences between AQP4 antibody positive and negative patients with NMOSD, including features of NMOSD with antibodies against myelin oligodendrocyte glycoprotein.Academia Brasileira de Neurologia - ABNEURO2014-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2014000600445Arquivos de Neuro-Psiquiatria v.72 n.6 2014reponame:Arquivos de neuro-psiquiatria (Online)instname:Academia Brasileira de Neurologiainstacron:ABNEURO10.1590/0004-282X20140032info:eu-repo/semantics/openAccessSato,Douglas KazutoshiCallegaro,DagobertoLana-Peixoto,Marco AurélioNakashima,IchiroFujihara,Kazuoeng2014-06-16T00:00:00Zoai:scielo:S0004-282X2014000600445Revistahttp://www.scielo.br/anphttps://old.scielo.br/oai/scielo-oai.php||revista.arquivos@abneuro.org1678-42270004-282Xopendoar:2014-06-16T00:00Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologiafalse |
dc.title.none.fl_str_mv |
Seronegative Neuromyelitis Optica Spectrum - The challenges on disease definition and pathogenesis |
title |
Seronegative Neuromyelitis Optica Spectrum - The challenges on disease definition and pathogenesis |
spellingShingle |
Seronegative Neuromyelitis Optica Spectrum - The challenges on disease definition and pathogenesis Sato,Douglas Kazutoshi neuromyelitis optica aquaporin-4 myelin oligodendrocyte glycoprotein antibody myelitis optic neuritis differential diagnosis |
title_short |
Seronegative Neuromyelitis Optica Spectrum - The challenges on disease definition and pathogenesis |
title_full |
Seronegative Neuromyelitis Optica Spectrum - The challenges on disease definition and pathogenesis |
title_fullStr |
Seronegative Neuromyelitis Optica Spectrum - The challenges on disease definition and pathogenesis |
title_full_unstemmed |
Seronegative Neuromyelitis Optica Spectrum - The challenges on disease definition and pathogenesis |
title_sort |
Seronegative Neuromyelitis Optica Spectrum - The challenges on disease definition and pathogenesis |
author |
Sato,Douglas Kazutoshi |
author_facet |
Sato,Douglas Kazutoshi Callegaro,Dagoberto Lana-Peixoto,Marco Aurélio Nakashima,Ichiro Fujihara,Kazuo |
author_role |
author |
author2 |
Callegaro,Dagoberto Lana-Peixoto,Marco Aurélio Nakashima,Ichiro Fujihara,Kazuo |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Sato,Douglas Kazutoshi Callegaro,Dagoberto Lana-Peixoto,Marco Aurélio Nakashima,Ichiro Fujihara,Kazuo |
dc.subject.por.fl_str_mv |
neuromyelitis optica aquaporin-4 myelin oligodendrocyte glycoprotein antibody myelitis optic neuritis differential diagnosis |
topic |
neuromyelitis optica aquaporin-4 myelin oligodendrocyte glycoprotein antibody myelitis optic neuritis differential diagnosis |
description |
Neuromyelitis optica spectrum disorders (NMOSD) are characterized by severe optic neuritis and/or longitudinally extensive transverse myelitis, and some brain lesions are also unique to NMOSD. Serum autoantibodies against aquaporin-4 (AQP4) are detected in most cases of NMOSD. However, some patients with NMOSD remain seronegative despite repetitive testing during attacks with highly sensitive cell-based assays. The differential diagnosis of NMOSD is not restricted to multiple sclerosis and it includes many diseases that can produce longitudinally extensive myelitis and/or optic neuritis. We review the clinical features, imaging, and laboratory findings that can be helpful on the diagnostic work-up, discuss the differences between AQP4 antibody positive and negative patients with NMOSD, including features of NMOSD with antibodies against myelin oligodendrocyte glycoprotein. |
publishDate |
2014 |
dc.date.none.fl_str_mv |
2014-06-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2014000600445 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2014000600445 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/0004-282X20140032 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Academia Brasileira de Neurologia - ABNEURO |
publisher.none.fl_str_mv |
Academia Brasileira de Neurologia - ABNEURO |
dc.source.none.fl_str_mv |
Arquivos de Neuro-Psiquiatria v.72 n.6 2014 reponame:Arquivos de neuro-psiquiatria (Online) instname:Academia Brasileira de Neurologia instacron:ABNEURO |
instname_str |
Academia Brasileira de Neurologia |
instacron_str |
ABNEURO |
institution |
ABNEURO |
reponame_str |
Arquivos de neuro-psiquiatria (Online) |
collection |
Arquivos de neuro-psiquiatria (Online) |
repository.name.fl_str_mv |
Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologia |
repository.mail.fl_str_mv |
||revista.arquivos@abneuro.org |
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1754212776421621760 |