Clinical presentation, treatment and outcome of patients with cerebral metastases: the University of São Paulo series
Autor(a) principal: | |
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Data de Publicação: | 2004 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Arquivos de neuro-psiquiatria (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2004000500013 |
Resumo: | INTRODUCTION: Secondary neoplasias are the most common tumors affecting the central nervous system and several clinical aspects of this disease are still controversial. METHOD: Forty-seven consecutive patients with the diagnosis of cerebral metastases (CM) were retrospectively studied at the Clinical Hospital of São Paulo University Medical School. Mean age was 53.9 years and 25 patients were female. RESULTS: The most frequent primary sites were breast, lung and skin. Symptoms were related to increased intracranial pressure (ICP) in 48.9%, focal neurological events in 27.7% and both in 17.0%. Single brain metastases were found in 57.4% of those cases, the frontal lobe being most frequently affected. Surgical treatment was performed in 68.1%, radiotherapy in 40.4% and chemotherapy in 17.0%. CONCLUSION: After statistical analysis, there was a trend towards prolonged survival of female patients, patients with ICP symptoms and the surgical group. Data from different centers are essential to establish the best management of CM. |
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Arquivos de neuro-psiquiatria (Online) |
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Clinical presentation, treatment and outcome of patients with cerebral metastases: the University of São Paulo seriesCNS tumorssecondary neoplasiascerebral metastasesINTRODUCTION: Secondary neoplasias are the most common tumors affecting the central nervous system and several clinical aspects of this disease are still controversial. METHOD: Forty-seven consecutive patients with the diagnosis of cerebral metastases (CM) were retrospectively studied at the Clinical Hospital of São Paulo University Medical School. Mean age was 53.9 years and 25 patients were female. RESULTS: The most frequent primary sites were breast, lung and skin. Symptoms were related to increased intracranial pressure (ICP) in 48.9%, focal neurological events in 27.7% and both in 17.0%. Single brain metastases were found in 57.4% of those cases, the frontal lobe being most frequently affected. Surgical treatment was performed in 68.1%, radiotherapy in 40.4% and chemotherapy in 17.0%. CONCLUSION: After statistical analysis, there was a trend towards prolonged survival of female patients, patients with ICP symptoms and the surgical group. Data from different centers are essential to establish the best management of CM.Academia Brasileira de Neurologia - ABNEURO2004-09-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2004000500013Arquivos de Neuro-Psiquiatria v.62 n.3b 2004reponame:Arquivos de neuro-psiquiatria (Online)instname:Academia Brasileira de Neurologiainstacron:ABNEURO10.1590/S0004-282X2004000500013info:eu-repo/semantics/openAccessAndrade,FernandaAguiar,Paulo HenriqueFontes,Ricardo Bragança de VasconcellosNakagawa,EdisonTeixeira,Joel AugustoMiura,Flavio KeyLepski,GuilhermeMarie,Suely Kazue NagahashiMarino Jr,Rauleng2004-10-05T00:00:00Zoai:scielo:S0004-282X2004000500013Revistahttp://www.scielo.br/anphttps://old.scielo.br/oai/scielo-oai.php||revista.arquivos@abneuro.org1678-42270004-282Xopendoar:2004-10-05T00:00Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologiafalse |
dc.title.none.fl_str_mv |
Clinical presentation, treatment and outcome of patients with cerebral metastases: the University of São Paulo series |
title |
Clinical presentation, treatment and outcome of patients with cerebral metastases: the University of São Paulo series |
spellingShingle |
Clinical presentation, treatment and outcome of patients with cerebral metastases: the University of São Paulo series Andrade,Fernanda CNS tumors secondary neoplasias cerebral metastases |
title_short |
Clinical presentation, treatment and outcome of patients with cerebral metastases: the University of São Paulo series |
title_full |
Clinical presentation, treatment and outcome of patients with cerebral metastases: the University of São Paulo series |
title_fullStr |
Clinical presentation, treatment and outcome of patients with cerebral metastases: the University of São Paulo series |
title_full_unstemmed |
Clinical presentation, treatment and outcome of patients with cerebral metastases: the University of São Paulo series |
title_sort |
Clinical presentation, treatment and outcome of patients with cerebral metastases: the University of São Paulo series |
author |
Andrade,Fernanda |
author_facet |
Andrade,Fernanda Aguiar,Paulo Henrique Fontes,Ricardo Bragança de Vasconcellos Nakagawa,Edison Teixeira,Joel Augusto Miura,Flavio Key Lepski,Guilherme Marie,Suely Kazue Nagahashi Marino Jr,Raul |
author_role |
author |
author2 |
Aguiar,Paulo Henrique Fontes,Ricardo Bragança de Vasconcellos Nakagawa,Edison Teixeira,Joel Augusto Miura,Flavio Key Lepski,Guilherme Marie,Suely Kazue Nagahashi Marino Jr,Raul |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
Andrade,Fernanda Aguiar,Paulo Henrique Fontes,Ricardo Bragança de Vasconcellos Nakagawa,Edison Teixeira,Joel Augusto Miura,Flavio Key Lepski,Guilherme Marie,Suely Kazue Nagahashi Marino Jr,Raul |
dc.subject.por.fl_str_mv |
CNS tumors secondary neoplasias cerebral metastases |
topic |
CNS tumors secondary neoplasias cerebral metastases |
description |
INTRODUCTION: Secondary neoplasias are the most common tumors affecting the central nervous system and several clinical aspects of this disease are still controversial. METHOD: Forty-seven consecutive patients with the diagnosis of cerebral metastases (CM) were retrospectively studied at the Clinical Hospital of São Paulo University Medical School. Mean age was 53.9 years and 25 patients were female. RESULTS: The most frequent primary sites were breast, lung and skin. Symptoms were related to increased intracranial pressure (ICP) in 48.9%, focal neurological events in 27.7% and both in 17.0%. Single brain metastases were found in 57.4% of those cases, the frontal lobe being most frequently affected. Surgical treatment was performed in 68.1%, radiotherapy in 40.4% and chemotherapy in 17.0%. CONCLUSION: After statistical analysis, there was a trend towards prolonged survival of female patients, patients with ICP symptoms and the surgical group. Data from different centers are essential to establish the best management of CM. |
publishDate |
2004 |
dc.date.none.fl_str_mv |
2004-09-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2004000500013 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2004000500013 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0004-282X2004000500013 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Academia Brasileira de Neurologia - ABNEURO |
publisher.none.fl_str_mv |
Academia Brasileira de Neurologia - ABNEURO |
dc.source.none.fl_str_mv |
Arquivos de Neuro-Psiquiatria v.62 n.3b 2004 reponame:Arquivos de neuro-psiquiatria (Online) instname:Academia Brasileira de Neurologia instacron:ABNEURO |
instname_str |
Academia Brasileira de Neurologia |
instacron_str |
ABNEURO |
institution |
ABNEURO |
reponame_str |
Arquivos de neuro-psiquiatria (Online) |
collection |
Arquivos de neuro-psiquiatria (Online) |
repository.name.fl_str_mv |
Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologia |
repository.mail.fl_str_mv |
||revista.arquivos@abneuro.org |
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