Working memory in Parkinson's disease patients: clinical features and response to levodopa
Autor(a) principal: | |
---|---|
Data de Publicação: | 2008 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Arquivos de neuro-psiquiatria (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2008000200001 |
Resumo: | OBJECTIVE: To evaluate the clinical features of the working memory (WM) in Parkinson's disease (PD) patients and to test the effect of levodopa on WM. METHOD: The paradigm was based on the 'n-back' tasks, which enables to study the level of executive demand (three levels of difficulty) and the domain of the information being processed (spatial items, faces and letters). The effect of levodopa was studied by testing PD patients in "on" and "off" states. RESULTS: PD patients performed less well in WM tasks than controls. There was no interaction between groups and complexity. Levodopa therapy had a positive effect only on spatial WM tasks but no effect on complexity. CONCLUSION: Our results suggest that impairment observed may result from a maintenance deficit within WM regardless the level of processing and levodopa therapy presents a positive effect on spatial WM. |
id |
ABNEURO-1_cad020c212d82ab9d40d9e7567fd1590 |
---|---|
oai_identifier_str |
oai:scielo:S0004-282X2008000200001 |
network_acronym_str |
ABNEURO-1 |
network_name_str |
Arquivos de neuro-psiquiatria (Online) |
repository_id_str |
|
spelling |
Working memory in Parkinson's disease patients: clinical features and response to levodopaParkinson's diseasestriatumexecutive functionsworking memorylevodopaOBJECTIVE: To evaluate the clinical features of the working memory (WM) in Parkinson's disease (PD) patients and to test the effect of levodopa on WM. METHOD: The paradigm was based on the 'n-back' tasks, which enables to study the level of executive demand (three levels of difficulty) and the domain of the information being processed (spatial items, faces and letters). The effect of levodopa was studied by testing PD patients in "on" and "off" states. RESULTS: PD patients performed less well in WM tasks than controls. There was no interaction between groups and complexity. Levodopa therapy had a positive effect only on spatial WM tasks but no effect on complexity. CONCLUSION: Our results suggest that impairment observed may result from a maintenance deficit within WM regardless the level of processing and levodopa therapy presents a positive effect on spatial WM.Academia Brasileira de Neurologia - ABNEURO2008-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2008000200001Arquivos de Neuro-Psiquiatria v.66 n.2a 2008reponame:Arquivos de neuro-psiquiatria (Online)instname:Academia Brasileira de Neurologiainstacron:ABNEURO10.1590/S0004-282X2008000200001info:eu-repo/semantics/openAccessBeato,RogérioLevy,RichardPillon,BernardVidal,Christinedu Montcel,Sophie TezenasDeweer,BernardBonnet,Anne-MarieHoueto,Jean-LucDubois,BrunoCardoso,Franciscoeng2008-06-02T00:00:00Zoai:scielo:S0004-282X2008000200001Revistahttp://www.scielo.br/anphttps://old.scielo.br/oai/scielo-oai.php||revista.arquivos@abneuro.org1678-42270004-282Xopendoar:2008-06-02T00:00Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologiafalse |
dc.title.none.fl_str_mv |
Working memory in Parkinson's disease patients: clinical features and response to levodopa |
title |
Working memory in Parkinson's disease patients: clinical features and response to levodopa |
spellingShingle |
Working memory in Parkinson's disease patients: clinical features and response to levodopa Beato,Rogério Parkinson's disease striatum executive functions working memory levodopa |
title_short |
Working memory in Parkinson's disease patients: clinical features and response to levodopa |
title_full |
Working memory in Parkinson's disease patients: clinical features and response to levodopa |
title_fullStr |
Working memory in Parkinson's disease patients: clinical features and response to levodopa |
title_full_unstemmed |
Working memory in Parkinson's disease patients: clinical features and response to levodopa |
title_sort |
Working memory in Parkinson's disease patients: clinical features and response to levodopa |
author |
Beato,Rogério |
author_facet |
Beato,Rogério Levy,Richard Pillon,Bernard Vidal,Christine du Montcel,Sophie Tezenas Deweer,Bernard Bonnet,Anne-Marie Houeto,Jean-Luc Dubois,Bruno Cardoso,Francisco |
author_role |
author |
author2 |
Levy,Richard Pillon,Bernard Vidal,Christine du Montcel,Sophie Tezenas Deweer,Bernard Bonnet,Anne-Marie Houeto,Jean-Luc Dubois,Bruno Cardoso,Francisco |
author2_role |
author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Beato,Rogério Levy,Richard Pillon,Bernard Vidal,Christine du Montcel,Sophie Tezenas Deweer,Bernard Bonnet,Anne-Marie Houeto,Jean-Luc Dubois,Bruno Cardoso,Francisco |
dc.subject.por.fl_str_mv |
Parkinson's disease striatum executive functions working memory levodopa |
topic |
Parkinson's disease striatum executive functions working memory levodopa |
description |
OBJECTIVE: To evaluate the clinical features of the working memory (WM) in Parkinson's disease (PD) patients and to test the effect of levodopa on WM. METHOD: The paradigm was based on the 'n-back' tasks, which enables to study the level of executive demand (three levels of difficulty) and the domain of the information being processed (spatial items, faces and letters). The effect of levodopa was studied by testing PD patients in "on" and "off" states. RESULTS: PD patients performed less well in WM tasks than controls. There was no interaction between groups and complexity. Levodopa therapy had a positive effect only on spatial WM tasks but no effect on complexity. CONCLUSION: Our results suggest that impairment observed may result from a maintenance deficit within WM regardless the level of processing and levodopa therapy presents a positive effect on spatial WM. |
publishDate |
2008 |
dc.date.none.fl_str_mv |
2008-06-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2008000200001 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2008000200001 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0004-282X2008000200001 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Academia Brasileira de Neurologia - ABNEURO |
publisher.none.fl_str_mv |
Academia Brasileira de Neurologia - ABNEURO |
dc.source.none.fl_str_mv |
Arquivos de Neuro-Psiquiatria v.66 n.2a 2008 reponame:Arquivos de neuro-psiquiatria (Online) instname:Academia Brasileira de Neurologia instacron:ABNEURO |
instname_str |
Academia Brasileira de Neurologia |
instacron_str |
ABNEURO |
institution |
ABNEURO |
reponame_str |
Arquivos de neuro-psiquiatria (Online) |
collection |
Arquivos de neuro-psiquiatria (Online) |
repository.name.fl_str_mv |
Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologia |
repository.mail.fl_str_mv |
||revista.arquivos@abneuro.org |
_version_ |
1754212763668840448 |