Exposure to pesticides and heterozygote genotype of GSTP1-Alw26I are associated to Parkinson's disease

• Autor(a) principal: Longo,Gabriela S.
• Data de Publicação: 2013
• Outros Autores: Pinhel,Marcela S., Sado,Caroline L., Gregório,Michele L., Amorim,Gisele S., Florim,Greiciane S., Mazeti,Camila M., Martins,Denise P., Oliveira,Fábio N., Tognola,Waldir A., Nakazone,Marcelo A., Souza,Dorotéia R. S.
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Arquivos de neuro-psiquiatria (Online)
• Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2013000700446
• topic: glutathione transferase; genetic polymorphism; Parkinson disease; xenobiotics

ObjectiveThis study aimed to analyze the frequency of GSTP1-Alw26I polymorphism and to estimate its association with toxic substances in Parkinson's disease (PD).MethodsA study group with 154 patients - subdivided into familial and sporadic PD groups - and 158 elderly individuals without the disease (control group) were evaluated. GSTP1-Alw26I polymorphism was analyzed by polymerase chain reaction/restriction fragment length polymorphism (PCR-RFLP).ResultsPatients were significantly more exposed to pesticides compared with the control group (p=0.0004), and the heterozygote genotype associated to exposure to pesticides also prevailed in patients (p=0.0001). Wild homozygote genotype was related to tobacco use (p=0.043) and alcoholism (p=0.033) in familial PD patients.ConclusionExposure to pesticides is associated to PD, whose effect can be enhanced when combined with the heterozygote genotype of GSTP1-Alw26I. Also, large genetic and environmental studies considering tobacco use, alcoholism, GSTP1 and PD are necessary to confirm our findings.