Impact of autologous hematopoetic stem cell transplantation on the quality of life of patients with multiple sclerosis

Detalhes bibliográficos
Autor(a) principal: Guimarães,Fabio Augusto Bronzi
Data de Publicação: 2010
Outros Autores: Oliveira-Cardoso,Érika Arantes de, Mastropietro,Ana Paula, Voltarelli,Júlio César, Santos,Manoel Antônio dos
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Arquivos de neuro-psiquiatria (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2010000400009
Resumo: OBJECTIVE: To evaluate the impact of autologous hematopoetic stem cell transplantation (autoHSCT) in the health related quality of life (HRQL) in patients with multiple sclerosis. METHOD: The sample consisted of 34 patients, over 18 years old, treated at a University Hospital in the state of São Paulo, Brazil. For data collection MOS SF-36 and EDSS scales were applied at three time points: admission of the patient, hospital discharge and 1 year posttransplantation. RESULTS: 27 patients (79%) showed stabilization or neurological improvement 1 year posttransplantation. At this time point, there was statistically significant improvement in all domains of the HRQoL. When EDSS scores were correlated with the domains of the MOS SF-36 scale, statistically significant correlations were found with physical functioning at the three time points analysed. CONCLUSION: In spite of the high risk of complications of the procedure, the HSCT had positive impact in the health related quality of life.
id ABNEURO-1_f5015ca71dd624affba182f37ab27647
oai_identifier_str oai:scielo:S0004-282X2010000400009
network_acronym_str ABNEURO-1
network_name_str Arquivos de neuro-psiquiatria (Online)
repository_id_str
spelling Impact of autologous hematopoetic stem cell transplantation on the quality of life of patients with multiple sclerosisquality of lifemultiple sclerosisbone marrow transplantationOBJECTIVE: To evaluate the impact of autologous hematopoetic stem cell transplantation (autoHSCT) in the health related quality of life (HRQL) in patients with multiple sclerosis. METHOD: The sample consisted of 34 patients, over 18 years old, treated at a University Hospital in the state of São Paulo, Brazil. For data collection MOS SF-36 and EDSS scales were applied at three time points: admission of the patient, hospital discharge and 1 year posttransplantation. RESULTS: 27 patients (79%) showed stabilization or neurological improvement 1 year posttransplantation. At this time point, there was statistically significant improvement in all domains of the HRQoL. When EDSS scores were correlated with the domains of the MOS SF-36 scale, statistically significant correlations were found with physical functioning at the three time points analysed. CONCLUSION: In spite of the high risk of complications of the procedure, the HSCT had positive impact in the health related quality of life.Academia Brasileira de Neurologia - ABNEURO2010-08-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2010000400009Arquivos de Neuro-Psiquiatria v.68 n.4 2010reponame:Arquivos de neuro-psiquiatria (Online)instname:Academia Brasileira de Neurologiainstacron:ABNEURO10.1590/S0004-282X2010000400009info:eu-repo/semantics/openAccessGuimarães,Fabio Augusto BronziOliveira-Cardoso,Érika Arantes deMastropietro,Ana PaulaVoltarelli,Júlio CésarSantos,Manoel Antônio doseng2010-08-11T00:00:00Zoai:scielo:S0004-282X2010000400009Revistahttp://www.scielo.br/anphttps://old.scielo.br/oai/scielo-oai.php||revista.arquivos@abneuro.org1678-42270004-282Xopendoar:2010-08-11T00:00Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologiafalse
dc.title.none.fl_str_mv Impact of autologous hematopoetic stem cell transplantation on the quality of life of patients with multiple sclerosis
title Impact of autologous hematopoetic stem cell transplantation on the quality of life of patients with multiple sclerosis
spellingShingle Impact of autologous hematopoetic stem cell transplantation on the quality of life of patients with multiple sclerosis
Guimarães,Fabio Augusto Bronzi
quality of life
multiple sclerosis
bone marrow transplantation
title_short Impact of autologous hematopoetic stem cell transplantation on the quality of life of patients with multiple sclerosis
title_full Impact of autologous hematopoetic stem cell transplantation on the quality of life of patients with multiple sclerosis
title_fullStr Impact of autologous hematopoetic stem cell transplantation on the quality of life of patients with multiple sclerosis
title_full_unstemmed Impact of autologous hematopoetic stem cell transplantation on the quality of life of patients with multiple sclerosis
title_sort Impact of autologous hematopoetic stem cell transplantation on the quality of life of patients with multiple sclerosis
author Guimarães,Fabio Augusto Bronzi
author_facet Guimarães,Fabio Augusto Bronzi
Oliveira-Cardoso,Érika Arantes de
Mastropietro,Ana Paula
Voltarelli,Júlio César
Santos,Manoel Antônio dos
author_role author
author2 Oliveira-Cardoso,Érika Arantes de
Mastropietro,Ana Paula
Voltarelli,Júlio César
Santos,Manoel Antônio dos
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Guimarães,Fabio Augusto Bronzi
Oliveira-Cardoso,Érika Arantes de
Mastropietro,Ana Paula
Voltarelli,Júlio César
Santos,Manoel Antônio dos
dc.subject.por.fl_str_mv quality of life
multiple sclerosis
bone marrow transplantation
topic quality of life
multiple sclerosis
bone marrow transplantation
description OBJECTIVE: To evaluate the impact of autologous hematopoetic stem cell transplantation (autoHSCT) in the health related quality of life (HRQL) in patients with multiple sclerosis. METHOD: The sample consisted of 34 patients, over 18 years old, treated at a University Hospital in the state of São Paulo, Brazil. For data collection MOS SF-36 and EDSS scales were applied at three time points: admission of the patient, hospital discharge and 1 year posttransplantation. RESULTS: 27 patients (79%) showed stabilization or neurological improvement 1 year posttransplantation. At this time point, there was statistically significant improvement in all domains of the HRQoL. When EDSS scores were correlated with the domains of the MOS SF-36 scale, statistically significant correlations were found with physical functioning at the three time points analysed. CONCLUSION: In spite of the high risk of complications of the procedure, the HSCT had positive impact in the health related quality of life.
publishDate 2010
dc.date.none.fl_str_mv 2010-08-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2010000400009
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2010000400009
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0004-282X2010000400009
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Academia Brasileira de Neurologia - ABNEURO
publisher.none.fl_str_mv Academia Brasileira de Neurologia - ABNEURO
dc.source.none.fl_str_mv Arquivos de Neuro-Psiquiatria v.68 n.4 2010
reponame:Arquivos de neuro-psiquiatria (Online)
instname:Academia Brasileira de Neurologia
instacron:ABNEURO
instname_str Academia Brasileira de Neurologia
instacron_str ABNEURO
institution ABNEURO
reponame_str Arquivos de neuro-psiquiatria (Online)
collection Arquivos de neuro-psiquiatria (Online)
repository.name.fl_str_mv Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologia
repository.mail.fl_str_mv ||revista.arquivos@abneuro.org
_version_ 1754212768906477568

Registros relacionados