Grade I meningiomas with atypical characteristics: a worse prognosis
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Arquivos de neuro-psiquiatria (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2018001100756 |
Resumo: | ABSTRACT The study reviewed the histology of cases of grade I meningiomas with spontaneous necrosis, grade I without necrosis and grade II meningiomas, to evaluate the histological and immunohistochemical factors of the patients’ prognosis, while correlating the clinicopathological features with the clinical follow-up of the patients. A review of 47 cases from the Department of Pathology of UNIFESP was performed and the samples were submitted to immunohistochemical examination with the p53 protein, Ki-67 cell proliferation factor and progesterone receptor markers. A greater expression was found in the progression of several degrees of aggressiveness for p53 and Ki-67, and a higher frequency of progesterone receptors in the lower degrees. The group of grade I meningiomas with spontaneous necrosis showed histological and immunohistochemical indexes that approximate those of the grade II meningioma. This suggests a worse prognosis for grade I meningiomas with necrosis. |
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Arquivos de neuro-psiquiatria (Online) |
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Grade I meningiomas with atypical characteristics: a worse prognosismeningiomaimmunohistochemistryprognosisnecrosisABSTRACT The study reviewed the histology of cases of grade I meningiomas with spontaneous necrosis, grade I without necrosis and grade II meningiomas, to evaluate the histological and immunohistochemical factors of the patients’ prognosis, while correlating the clinicopathological features with the clinical follow-up of the patients. A review of 47 cases from the Department of Pathology of UNIFESP was performed and the samples were submitted to immunohistochemical examination with the p53 protein, Ki-67 cell proliferation factor and progesterone receptor markers. A greater expression was found in the progression of several degrees of aggressiveness for p53 and Ki-67, and a higher frequency of progesterone receptors in the lower degrees. The group of grade I meningiomas with spontaneous necrosis showed histological and immunohistochemical indexes that approximate those of the grade II meningioma. This suggests a worse prognosis for grade I meningiomas with necrosis.Academia Brasileira de Neurologia - ABNEURO2018-11-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2018001100756Arquivos de Neuro-Psiquiatria v.76 n.11 2018reponame:Arquivos de neuro-psiquiatria (Online)instname:Academia Brasileira de Neurologiainstacron:ABNEURO10.1590/0004-282x20180121info:eu-repo/semantics/openAccessMarcos,Débora S.Paiva Neto,Manoel A.Góes,PedroOshima,Celina T. F.Silva,Marcelo S.Stávale,João N.eng2018-12-10T00:00:00Zoai:scielo:S0004-282X2018001100756Revistahttp://www.scielo.br/anphttps://old.scielo.br/oai/scielo-oai.php||revista.arquivos@abneuro.org1678-42270004-282Xopendoar:2018-12-10T00:00Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologiafalse |
dc.title.none.fl_str_mv |
Grade I meningiomas with atypical characteristics: a worse prognosis |
title |
Grade I meningiomas with atypical characteristics: a worse prognosis |
spellingShingle |
Grade I meningiomas with atypical characteristics: a worse prognosis Marcos,Débora S. meningioma immunohistochemistry prognosis necrosis |
title_short |
Grade I meningiomas with atypical characteristics: a worse prognosis |
title_full |
Grade I meningiomas with atypical characteristics: a worse prognosis |
title_fullStr |
Grade I meningiomas with atypical characteristics: a worse prognosis |
title_full_unstemmed |
Grade I meningiomas with atypical characteristics: a worse prognosis |
title_sort |
Grade I meningiomas with atypical characteristics: a worse prognosis |
author |
Marcos,Débora S. |
author_facet |
Marcos,Débora S. Paiva Neto,Manoel A. Góes,Pedro Oshima,Celina T. F. Silva,Marcelo S. Stávale,João N. |
author_role |
author |
author2 |
Paiva Neto,Manoel A. Góes,Pedro Oshima,Celina T. F. Silva,Marcelo S. Stávale,João N. |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Marcos,Débora S. Paiva Neto,Manoel A. Góes,Pedro Oshima,Celina T. F. Silva,Marcelo S. Stávale,João N. |
dc.subject.por.fl_str_mv |
meningioma immunohistochemistry prognosis necrosis |
topic |
meningioma immunohistochemistry prognosis necrosis |
description |
ABSTRACT The study reviewed the histology of cases of grade I meningiomas with spontaneous necrosis, grade I without necrosis and grade II meningiomas, to evaluate the histological and immunohistochemical factors of the patients’ prognosis, while correlating the clinicopathological features with the clinical follow-up of the patients. A review of 47 cases from the Department of Pathology of UNIFESP was performed and the samples were submitted to immunohistochemical examination with the p53 protein, Ki-67 cell proliferation factor and progesterone receptor markers. A greater expression was found in the progression of several degrees of aggressiveness for p53 and Ki-67, and a higher frequency of progesterone receptors in the lower degrees. The group of grade I meningiomas with spontaneous necrosis showed histological and immunohistochemical indexes that approximate those of the grade II meningioma. This suggests a worse prognosis for grade I meningiomas with necrosis. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-11-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2018001100756 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2018001100756 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/0004-282x20180121 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Academia Brasileira de Neurologia - ABNEURO |
publisher.none.fl_str_mv |
Academia Brasileira de Neurologia - ABNEURO |
dc.source.none.fl_str_mv |
Arquivos de Neuro-Psiquiatria v.76 n.11 2018 reponame:Arquivos de neuro-psiquiatria (Online) instname:Academia Brasileira de Neurologia instacron:ABNEURO |
instname_str |
Academia Brasileira de Neurologia |
instacron_str |
ABNEURO |
institution |
ABNEURO |
reponame_str |
Arquivos de neuro-psiquiatria (Online) |
collection |
Arquivos de neuro-psiquiatria (Online) |
repository.name.fl_str_mv |
Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologia |
repository.mail.fl_str_mv |
||revista.arquivos@abneuro.org |
_version_ |
1754212784502996992 |