Fluvoxamine alters the activity of energy metabolism enzymes in the brain
Autor(a) principal: | |
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Data de Publicação: | 2014 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Brazilian Journal of Psychiatry (São Paulo. 1999. Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-44462014000300220 |
Resumo: | Objective: Several studies support the hypothesis that metabolism impairment is involved in the pathophysiology of depression and that some antidepressants act by modulating brain energy metabolism. Thus, we evaluated the activity of Krebs cycle enzymes, the mitochondrial respiratory chain, and creatine kinase in the brain of rats subjected to prolonged administration of fluvoxamine. Methods: Wistar rats received daily administration of fluvoxamine in saline (10, 30, and 60 mg/kg) for 14 days. Twelve hours after the last administration, rats were killed by decapitation and the prefrontal cortex, cerebral cortex, hippocampus, striatum, and cerebellum were rapidly isolated. Results: The activities of citrate synthase, malate dehydrogenase, and complexes I, II-III, and IV were decreased after prolonged administration of fluvoxamine in rats. However, the activities of complex II, succinate dehydrogenase, and creatine kinase were increased. Conclusions: Alterations in activity of energy metabolism enzymes were observed in most brain areas analyzed. Thus, we suggest that the decrease in citrate synthase, malate dehydrogenase, and complexes I, II-III, and IV can be related to adverse effects of pharmacotherapy, but long-term molecular adaptations cannot be ruled out. In addition, we demonstrated that these changes varied according to brain structure or biochemical analysis and were not dose-dependent. |
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Brazilian Journal of Psychiatry (São Paulo. 1999. Online) |
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Fluvoxamine alters the activity of energy metabolism enzymes in the brainBraincreatine kinasefluvoxamineKrebs cyclemitochondrial respiratory chain Objective: Several studies support the hypothesis that metabolism impairment is involved in the pathophysiology of depression and that some antidepressants act by modulating brain energy metabolism. Thus, we evaluated the activity of Krebs cycle enzymes, the mitochondrial respiratory chain, and creatine kinase in the brain of rats subjected to prolonged administration of fluvoxamine. Methods: Wistar rats received daily administration of fluvoxamine in saline (10, 30, and 60 mg/kg) for 14 days. Twelve hours after the last administration, rats were killed by decapitation and the prefrontal cortex, cerebral cortex, hippocampus, striatum, and cerebellum were rapidly isolated. Results: The activities of citrate synthase, malate dehydrogenase, and complexes I, II-III, and IV were decreased after prolonged administration of fluvoxamine in rats. However, the activities of complex II, succinate dehydrogenase, and creatine kinase were increased. Conclusions: Alterations in activity of energy metabolism enzymes were observed in most brain areas analyzed. Thus, we suggest that the decrease in citrate synthase, malate dehydrogenase, and complexes I, II-III, and IV can be related to adverse effects of pharmacotherapy, but long-term molecular adaptations cannot be ruled out. In addition, we demonstrated that these changes varied according to brain structure or biochemical analysis and were not dose-dependent. Associação Brasileira de Psiquiatria2014-09-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-44462014000300220Brazilian Journal of Psychiatry v.36 n.3 2014reponame:Brazilian Journal of Psychiatry (São Paulo. 1999. Online)instname:Associação Brasileira de Psiquiatria (ABP)instacron:ABP10.1590/1516-4446-2013-1202info:eu-repo/semantics/openAccessFerreira,Gabriela K.Cardoso,Mariane R.Jeremias,Isabela C.Gonçalves,Cinara L.Freitas,Karolina V.Antonini,RafaelaScaini,GiselliRezin,Gislaine T.Quevedo,JoãoStreck,Emilio L.eng2014-11-25T00:00:00Zoai:scielo:S1516-44462014000300220Revistahttp://www.bjp.org.br/ahead_of_print.asphttps://old.scielo.br/oai/scielo-oai.php||rbp@abpbrasil.org.br1809-452X1516-4446opendoar:2014-11-25T00:00Brazilian Journal of Psychiatry (São Paulo. 1999. Online) - Associação Brasileira de Psiquiatria (ABP)false |
dc.title.none.fl_str_mv |
Fluvoxamine alters the activity of energy metabolism enzymes in the brain |
title |
Fluvoxamine alters the activity of energy metabolism enzymes in the brain |
spellingShingle |
Fluvoxamine alters the activity of energy metabolism enzymes in the brain Ferreira,Gabriela K. Brain creatine kinase fluvoxamine Krebs cycle mitochondrial respiratory chain |
title_short |
Fluvoxamine alters the activity of energy metabolism enzymes in the brain |
title_full |
Fluvoxamine alters the activity of energy metabolism enzymes in the brain |
title_fullStr |
Fluvoxamine alters the activity of energy metabolism enzymes in the brain |
title_full_unstemmed |
Fluvoxamine alters the activity of energy metabolism enzymes in the brain |
title_sort |
Fluvoxamine alters the activity of energy metabolism enzymes in the brain |
author |
Ferreira,Gabriela K. |
author_facet |
Ferreira,Gabriela K. Cardoso,Mariane R. Jeremias,Isabela C. Gonçalves,Cinara L. Freitas,Karolina V. Antonini,Rafaela Scaini,Giselli Rezin,Gislaine T. Quevedo,João Streck,Emilio L. |
author_role |
author |
author2 |
Cardoso,Mariane R. Jeremias,Isabela C. Gonçalves,Cinara L. Freitas,Karolina V. Antonini,Rafaela Scaini,Giselli Rezin,Gislaine T. Quevedo,João Streck,Emilio L. |
author2_role |
author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Ferreira,Gabriela K. Cardoso,Mariane R. Jeremias,Isabela C. Gonçalves,Cinara L. Freitas,Karolina V. Antonini,Rafaela Scaini,Giselli Rezin,Gislaine T. Quevedo,João Streck,Emilio L. |
dc.subject.por.fl_str_mv |
Brain creatine kinase fluvoxamine Krebs cycle mitochondrial respiratory chain |
topic |
Brain creatine kinase fluvoxamine Krebs cycle mitochondrial respiratory chain |
description |
Objective: Several studies support the hypothesis that metabolism impairment is involved in the pathophysiology of depression and that some antidepressants act by modulating brain energy metabolism. Thus, we evaluated the activity of Krebs cycle enzymes, the mitochondrial respiratory chain, and creatine kinase in the brain of rats subjected to prolonged administration of fluvoxamine. Methods: Wistar rats received daily administration of fluvoxamine in saline (10, 30, and 60 mg/kg) for 14 days. Twelve hours after the last administration, rats were killed by decapitation and the prefrontal cortex, cerebral cortex, hippocampus, striatum, and cerebellum were rapidly isolated. Results: The activities of citrate synthase, malate dehydrogenase, and complexes I, II-III, and IV were decreased after prolonged administration of fluvoxamine in rats. However, the activities of complex II, succinate dehydrogenase, and creatine kinase were increased. Conclusions: Alterations in activity of energy metabolism enzymes were observed in most brain areas analyzed. Thus, we suggest that the decrease in citrate synthase, malate dehydrogenase, and complexes I, II-III, and IV can be related to adverse effects of pharmacotherapy, but long-term molecular adaptations cannot be ruled out. In addition, we demonstrated that these changes varied according to brain structure or biochemical analysis and were not dose-dependent. |
publishDate |
2014 |
dc.date.none.fl_str_mv |
2014-09-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-44462014000300220 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-44462014000300220 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/1516-4446-2013-1202 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Associação Brasileira de Psiquiatria |
publisher.none.fl_str_mv |
Associação Brasileira de Psiquiatria |
dc.source.none.fl_str_mv |
Brazilian Journal of Psychiatry v.36 n.3 2014 reponame:Brazilian Journal of Psychiatry (São Paulo. 1999. Online) instname:Associação Brasileira de Psiquiatria (ABP) instacron:ABP |
instname_str |
Associação Brasileira de Psiquiatria (ABP) |
instacron_str |
ABP |
institution |
ABP |
reponame_str |
Brazilian Journal of Psychiatry (São Paulo. 1999. Online) |
collection |
Brazilian Journal of Psychiatry (São Paulo. 1999. Online) |
repository.name.fl_str_mv |
Brazilian Journal of Psychiatry (São Paulo. 1999. Online) - Associação Brasileira de Psiquiatria (ABP) |
repository.mail.fl_str_mv |
||rbp@abpbrasil.org.br |
_version_ |
1754212556466028544 |