Neurocircuit models of obsessive-compulsive disorder: limitations and future directions for research
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Brazilian Journal of Psychiatry (São Paulo. 1999. Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-44462022000200187 |
Resumo: | Obsessive-compulsive disorder (OCD) is a common psychiatric condition classically characterized by obsessions (recurrent, intrusive and unwanted thoughts) and compulsions (excessive, repetitive and ritualistic behaviors or mental acts). OCD is heterogeneous in its clinical presentation and not all patients respond to first-line treatments. Several neurocircuit models of OCD have been proposed with the aim of providing a better understanding of the neural and cognitive mechanisms involved in the disorder. These models use advances in neuroscience and findings from neuropsychological and neuroimaging studies to suggest links between clinical profiles that reflect the symptoms and experiences of patients and dysfunctions in specific neurocircuits. Several models propose that treatments for OCD could be improved if directed to specific neurocircuit dysfunctions, thereby restoring efficient neurocognitive function and ameliorating the symptomatology of each associated clinical profile. Yet, there are several important limitations to neurocircuit models of OCD. The purpose of the current review is to highlight some of these limitations, including issues related to the complexity of brain and cognitive function, the clinical presentation and course of OCD, etiological factors, and treatment methods proposed by the models. We also provide suggestions for future research to advance neurocircuit models of OCD and facilitate translation to clinical application. |
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Brazilian Journal of Psychiatry (São Paulo. 1999. Online) |
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Neurocircuit models of obsessive-compulsive disorder: limitations and future directions for researchObsessive-compulsive disorderclinical presentationneurocircuit modelsneurobiologytreatment advancesObsessive-compulsive disorder (OCD) is a common psychiatric condition classically characterized by obsessions (recurrent, intrusive and unwanted thoughts) and compulsions (excessive, repetitive and ritualistic behaviors or mental acts). OCD is heterogeneous in its clinical presentation and not all patients respond to first-line treatments. Several neurocircuit models of OCD have been proposed with the aim of providing a better understanding of the neural and cognitive mechanisms involved in the disorder. These models use advances in neuroscience and findings from neuropsychological and neuroimaging studies to suggest links between clinical profiles that reflect the symptoms and experiences of patients and dysfunctions in specific neurocircuits. Several models propose that treatments for OCD could be improved if directed to specific neurocircuit dysfunctions, thereby restoring efficient neurocognitive function and ameliorating the symptomatology of each associated clinical profile. Yet, there are several important limitations to neurocircuit models of OCD. The purpose of the current review is to highlight some of these limitations, including issues related to the complexity of brain and cognitive function, the clinical presentation and course of OCD, etiological factors, and treatment methods proposed by the models. We also provide suggestions for future research to advance neurocircuit models of OCD and facilitate translation to clinical application.Associação Brasileira de Psiquiatria2022-04-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-44462022000200187Brazilian Journal of Psychiatry v.44 n.2 2022reponame:Brazilian Journal of Psychiatry (São Paulo. 1999. Online)instname:Associação Brasileira de Psiquiatria (ABP)instacron:ABP10.1590/1516-4446-2020-1709info:eu-repo/semantics/openAccessShephard,ElizabethBatistuzzo,Marcelo C.Hoexter,Marcelo Q.Stern,Emily R.Zuccolo,Pedro F.Ogawa,Carolina Y.Silva,Renata M.Brunoni,Andre R.Costa,Daniel L.Doretto,VictoriaSaraiva,LeonardoCappi,CarolinaShavitt,Roseli G.Simpson,H. Blairvan den Heuvel,Odile A.Miguel,Euripedes C.eng2022-04-25T00:00:00Zoai:scielo:S1516-44462022000200187Revistahttp://www.bjp.org.br/ahead_of_print.asphttps://old.scielo.br/oai/scielo-oai.php||rbp@abpbrasil.org.br1809-452X1516-4446opendoar:2022-04-25T00:00Brazilian Journal of Psychiatry (São Paulo. 1999. Online) - Associação Brasileira de Psiquiatria (ABP)false |
dc.title.none.fl_str_mv |
Neurocircuit models of obsessive-compulsive disorder: limitations and future directions for research |
title |
Neurocircuit models of obsessive-compulsive disorder: limitations and future directions for research |
spellingShingle |
Neurocircuit models of obsessive-compulsive disorder: limitations and future directions for research Shephard,Elizabeth Obsessive-compulsive disorder clinical presentation neurocircuit models neurobiology treatment advances |
title_short |
Neurocircuit models of obsessive-compulsive disorder: limitations and future directions for research |
title_full |
Neurocircuit models of obsessive-compulsive disorder: limitations and future directions for research |
title_fullStr |
Neurocircuit models of obsessive-compulsive disorder: limitations and future directions for research |
title_full_unstemmed |
Neurocircuit models of obsessive-compulsive disorder: limitations and future directions for research |
title_sort |
Neurocircuit models of obsessive-compulsive disorder: limitations and future directions for research |
author |
Shephard,Elizabeth |
author_facet |
Shephard,Elizabeth Batistuzzo,Marcelo C. Hoexter,Marcelo Q. Stern,Emily R. Zuccolo,Pedro F. Ogawa,Carolina Y. Silva,Renata M. Brunoni,Andre R. Costa,Daniel L. Doretto,Victoria Saraiva,Leonardo Cappi,Carolina Shavitt,Roseli G. Simpson,H. Blair van den Heuvel,Odile A. Miguel,Euripedes C. |
author_role |
author |
author2 |
Batistuzzo,Marcelo C. Hoexter,Marcelo Q. Stern,Emily R. Zuccolo,Pedro F. Ogawa,Carolina Y. Silva,Renata M. Brunoni,Andre R. Costa,Daniel L. Doretto,Victoria Saraiva,Leonardo Cappi,Carolina Shavitt,Roseli G. Simpson,H. Blair van den Heuvel,Odile A. Miguel,Euripedes C. |
author2_role |
author author author author author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Shephard,Elizabeth Batistuzzo,Marcelo C. Hoexter,Marcelo Q. Stern,Emily R. Zuccolo,Pedro F. Ogawa,Carolina Y. Silva,Renata M. Brunoni,Andre R. Costa,Daniel L. Doretto,Victoria Saraiva,Leonardo Cappi,Carolina Shavitt,Roseli G. Simpson,H. Blair van den Heuvel,Odile A. Miguel,Euripedes C. |
dc.subject.por.fl_str_mv |
Obsessive-compulsive disorder clinical presentation neurocircuit models neurobiology treatment advances |
topic |
Obsessive-compulsive disorder clinical presentation neurocircuit models neurobiology treatment advances |
description |
Obsessive-compulsive disorder (OCD) is a common psychiatric condition classically characterized by obsessions (recurrent, intrusive and unwanted thoughts) and compulsions (excessive, repetitive and ritualistic behaviors or mental acts). OCD is heterogeneous in its clinical presentation and not all patients respond to first-line treatments. Several neurocircuit models of OCD have been proposed with the aim of providing a better understanding of the neural and cognitive mechanisms involved in the disorder. These models use advances in neuroscience and findings from neuropsychological and neuroimaging studies to suggest links between clinical profiles that reflect the symptoms and experiences of patients and dysfunctions in specific neurocircuits. Several models propose that treatments for OCD could be improved if directed to specific neurocircuit dysfunctions, thereby restoring efficient neurocognitive function and ameliorating the symptomatology of each associated clinical profile. Yet, there are several important limitations to neurocircuit models of OCD. The purpose of the current review is to highlight some of these limitations, including issues related to the complexity of brain and cognitive function, the clinical presentation and course of OCD, etiological factors, and treatment methods proposed by the models. We also provide suggestions for future research to advance neurocircuit models of OCD and facilitate translation to clinical application. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-04-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-44462022000200187 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-44462022000200187 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/1516-4446-2020-1709 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Associação Brasileira de Psiquiatria |
publisher.none.fl_str_mv |
Associação Brasileira de Psiquiatria |
dc.source.none.fl_str_mv |
Brazilian Journal of Psychiatry v.44 n.2 2022 reponame:Brazilian Journal of Psychiatry (São Paulo. 1999. Online) instname:Associação Brasileira de Psiquiatria (ABP) instacron:ABP |
instname_str |
Associação Brasileira de Psiquiatria (ABP) |
instacron_str |
ABP |
institution |
ABP |
reponame_str |
Brazilian Journal of Psychiatry (São Paulo. 1999. Online) |
collection |
Brazilian Journal of Psychiatry (São Paulo. 1999. Online) |
repository.name.fl_str_mv |
Brazilian Journal of Psychiatry (São Paulo. 1999. Online) - Associação Brasileira de Psiquiatria (ABP) |
repository.mail.fl_str_mv |
||rbp@abpbrasil.org.br |
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