Animal model of mania induced by amphetamine as a method of identification of new therapeutic targets for bipolar disorder

Detalhes bibliográficos
Autor(a) principal: Varela, Roger Bitencourt
Data de Publicação: 2014
Outros Autores: Resende , Wilson Rodrigues, Quevedo, João
Tipo de documento: Artigo
Idioma: por
Título da fonte: Debates em Psiquiatria (Online)
Texto Completo: https://revistardp.org.br/revista/article/view/259
Resumo: Bipolar disorder is a severe mood disorder with high morbidity and mortality. Is characterized by recurrent manic and depressive episodes. Little is known about the precise neurobiology of TB, that is essential to the development of specifics therapies that work quickly and be more effective and better tolerable than existing therapies. Given the limitations of actual noninvasive technologies to study the human brain, the animal models of psychiatric disorders are one of the most relevant tools to neurobiological studies. This review focuses in some new therapeutic targets to the treatment of bipolar disorder, discovered through the animal model studies. Studies with animal model of mania induced by amphetamine shows excellent results indicating the involvement os oxidative stress, Protein Kinase C and histones deacetylase on bipolar pathophysiology, as its potential as therapeutics targets, however, these targets should be continuously explored on mood disorders
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spelling Animal model of mania induced by amphetamine as a method of identification of new therapeutic targets for bipolar disorderModelo animal de mania induzido por anfetamina como método de identificação de novos alvos terapêuticos para o transtorno bipolarTranstorno bipolarfisiopatologiaTerapêuticaBipolar disorderPathophysiologyTherapeuticsBipolar disorder is a severe mood disorder with high morbidity and mortality. Is characterized by recurrent manic and depressive episodes. Little is known about the precise neurobiology of TB, that is essential to the development of specifics therapies that work quickly and be more effective and better tolerable than existing therapies. Given the limitations of actual noninvasive technologies to study the human brain, the animal models of psychiatric disorders are one of the most relevant tools to neurobiological studies. This review focuses in some new therapeutic targets to the treatment of bipolar disorder, discovered through the animal model studies. Studies with animal model of mania induced by amphetamine shows excellent results indicating the involvement os oxidative stress, Protein Kinase C and histones deacetylase on bipolar pathophysiology, as its potential as therapeutics targets, however, these targets should be continuously explored on mood disordersO Transtorno Bipolar é um transtorno do humor grave com grande morbidade e mortalidade. É caracterizado por recorrentes episódios de mania e depressão. Pouco se sabe sobre a precisa neurobiologia do TB, que é essencial para o desenvolvimento de terapias específicas que funcionem rapidamente e sejam mais eficazes e toleráveis que as terapias existentes. Dadas as limitações das tecnologias não invasivas atuais para estudar o cérebro humano, os modelos animais de transtornos psiquiátricos são uma das ferramentas mais importantes para os estudos neurobiológicos. Nessa revisão são abordados alguns novos alvos terapêuticos para o tratamento do transtorno bipolar, descobertos através de estudo com modelos animais. Estudos com o modelo animal de mania induzido por anfetamina apresentam excelentes resultados apontando o envolvimento do estresse oxidativo, da Proteína Quinase C e das Histonas Deacetilases na fisiopatologia do transtorno bipolar, assim como seu potencial enquanto alvos terapêuticos, porém, esses alvos devem ser continuamente explorados nos transtornos de humor.Associação Brasileira de Psiquiatria2014-04-30info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionPeer-ReviewedRevisado por ParesAvaliado Pelos Paresapplication/pdfhttps://revistardp.org.br/revista/article/view/25910.25118/2763-9037.2014.v4.259Debates in Psychiatry; Vol. 4 No. 2 (2014); 6-14Debates em Psiquiatria; Vol. 4 Núm. 2 (2014); 6-14Debates em Psiquiatria; v. 4 n. 2 (2014); 6-142763-90372236-918Xreponame:Debates em Psiquiatria (Online)instname:Associação Brasileira de Psiquiatria (ABP)instacron:ABPporhttps://revistardp.org.br/revista/article/view/259/234Copyright (c) 2014 Roger Bitencourt Varela, Wilson Rodrigues Resende , João Quevedohttps://creativecommons.org/licenses/by-nc/4.0info:eu-repo/semantics/openAccessVarela, Roger BitencourtResende , Wilson RodriguesQuevedo, João2022-06-03T01:13:25Zoai:ojs.emnuvens.com.br:article/259Revistahttps://revistardp.org.br/revista/oaiPUBhttps://revistardp.org.br/revista/oairdp@abp.org.br2763-90372236-918Xopendoar:2022-06-03T01:13:25Debates em Psiquiatria (Online) - Associação Brasileira de Psiquiatria (ABP)false
dc.title.none.fl_str_mv Animal model of mania induced by amphetamine as a method of identification of new therapeutic targets for bipolar disorder
Modelo animal de mania induzido por anfetamina como método de identificação de novos alvos terapêuticos para o transtorno bipolar
title Animal model of mania induced by amphetamine as a method of identification of new therapeutic targets for bipolar disorder
spellingShingle Animal model of mania induced by amphetamine as a method of identification of new therapeutic targets for bipolar disorder
Varela, Roger Bitencourt
Transtorno bipolar
fisiopatologia
Terapêutica
Bipolar disorder
Pathophysiology
Therapeutics
title_short Animal model of mania induced by amphetamine as a method of identification of new therapeutic targets for bipolar disorder
title_full Animal model of mania induced by amphetamine as a method of identification of new therapeutic targets for bipolar disorder
title_fullStr Animal model of mania induced by amphetamine as a method of identification of new therapeutic targets for bipolar disorder
title_full_unstemmed Animal model of mania induced by amphetamine as a method of identification of new therapeutic targets for bipolar disorder
title_sort Animal model of mania induced by amphetamine as a method of identification of new therapeutic targets for bipolar disorder
author Varela, Roger Bitencourt
author_facet Varela, Roger Bitencourt
Resende , Wilson Rodrigues
Quevedo, João
author_role author
author2 Resende , Wilson Rodrigues
Quevedo, João
author2_role author
author
dc.contributor.author.fl_str_mv Varela, Roger Bitencourt
Resende , Wilson Rodrigues
Quevedo, João
dc.subject.por.fl_str_mv Transtorno bipolar
fisiopatologia
Terapêutica
Bipolar disorder
Pathophysiology
Therapeutics
topic Transtorno bipolar
fisiopatologia
Terapêutica
Bipolar disorder
Pathophysiology
Therapeutics
description Bipolar disorder is a severe mood disorder with high morbidity and mortality. Is characterized by recurrent manic and depressive episodes. Little is known about the precise neurobiology of TB, that is essential to the development of specifics therapies that work quickly and be more effective and better tolerable than existing therapies. Given the limitations of actual noninvasive technologies to study the human brain, the animal models of psychiatric disorders are one of the most relevant tools to neurobiological studies. This review focuses in some new therapeutic targets to the treatment of bipolar disorder, discovered through the animal model studies. Studies with animal model of mania induced by amphetamine shows excellent results indicating the involvement os oxidative stress, Protein Kinase C and histones deacetylase on bipolar pathophysiology, as its potential as therapeutics targets, however, these targets should be continuously explored on mood disorders
publishDate 2014
dc.date.none.fl_str_mv 2014-04-30
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-Reviewed
Revisado por Pares
Avaliado Pelos Pares
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://revistardp.org.br/revista/article/view/259
10.25118/2763-9037.2014.v4.259
url https://revistardp.org.br/revista/article/view/259
identifier_str_mv 10.25118/2763-9037.2014.v4.259
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://revistardp.org.br/revista/article/view/259/234
dc.rights.driver.fl_str_mv Copyright (c) 2014 Roger Bitencourt Varela, Wilson Rodrigues Resende , João Quevedo
https://creativecommons.org/licenses/by-nc/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2014 Roger Bitencourt Varela, Wilson Rodrigues Resende , João Quevedo
https://creativecommons.org/licenses/by-nc/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Associação Brasileira de Psiquiatria
publisher.none.fl_str_mv Associação Brasileira de Psiquiatria
dc.source.none.fl_str_mv Debates in Psychiatry; Vol. 4 No. 2 (2014); 6-14
Debates em Psiquiatria; Vol. 4 Núm. 2 (2014); 6-14
Debates em Psiquiatria; v. 4 n. 2 (2014); 6-14
2763-9037
2236-918X
reponame:Debates em Psiquiatria (Online)
instname:Associação Brasileira de Psiquiatria (ABP)
instacron:ABP
instname_str Associação Brasileira de Psiquiatria (ABP)
instacron_str ABP
institution ABP
reponame_str Debates em Psiquiatria (Online)
collection Debates em Psiquiatria (Online)
repository.name.fl_str_mv Debates em Psiquiatria (Online) - Associação Brasileira de Psiquiatria (ABP)
repository.mail.fl_str_mv rdp@abp.org.br
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