Retinol binding protein 4 and incident diabetes – the Atherosclerosis Risk in Communities Study (ARIC Study)
Autor(a) principal: | |
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Data de Publicação: | 2013 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Revista brasileira de epidemiologia (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-790X2013000200388 |
Resumo: | Background: Retinol binding protein 4 (RBP4) has been described as a link between impaired glucose uptake in adipocytes and systemic insulin sensitivity. Objective: To determine whether RBP4 fasting levels predict the development of type 2 diabetes. Methods: Using a case-cohort design, we followed 543 middle-aged individuals who developed diabetes and 537 who did not over ~9 years within the population-based Atherosclerosis Risk in Communities Study. Weighted Cox proportional hazards analyses permitted statistical inference of the RBP4 – incident diabetes associations to the entire cohort. Results: Women in the highest tertile of RBP4 presented greater risk of developing diabetes (HR = 1.74; 95%CI 1.03 – 2.94) in analyses adjusted for age, ethnicity, study center, parental history of diabetes, hypertension, glomerular filtration rate, body mass index, waist-hip ratio, nonesterified fatty acids, adiponectin, leptin, triglycerides and HDL-C. When additionally adjusted for fasting insulin, this association’s significance became borderline (HR = 1.68; 95%CI 1.00 – 2.82). No association between RBP4 levels and incident diabetes was found in men. Conclusion: These findings suggest that RBP4 levels may be directly involved in the pathogenesis of type 2 diabetes in women. |
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Retinol binding protein 4 and incident diabetes – the Atherosclerosis Risk in Communities Study (ARIC Study)DiabetesRetinol-Binding ProteinsRBP4 protein, humanEpidemiologic Studies Background: Retinol binding protein 4 (RBP4) has been described as a link between impaired glucose uptake in adipocytes and systemic insulin sensitivity. Objective: To determine whether RBP4 fasting levels predict the development of type 2 diabetes. Methods: Using a case-cohort design, we followed 543 middle-aged individuals who developed diabetes and 537 who did not over ~9 years within the population-based Atherosclerosis Risk in Communities Study. Weighted Cox proportional hazards analyses permitted statistical inference of the RBP4 – incident diabetes associations to the entire cohort. Results: Women in the highest tertile of RBP4 presented greater risk of developing diabetes (HR = 1.74; 95%CI 1.03 – 2.94) in analyses adjusted for age, ethnicity, study center, parental history of diabetes, hypertension, glomerular filtration rate, body mass index, waist-hip ratio, nonesterified fatty acids, adiponectin, leptin, triglycerides and HDL-C. When additionally adjusted for fasting insulin, this association’s significance became borderline (HR = 1.68; 95%CI 1.00 – 2.82). No association between RBP4 levels and incident diabetes was found in men. Conclusion: These findings suggest that RBP4 levels may be directly involved in the pathogenesis of type 2 diabetes in women. Associação Brasileira de Saúde Coletiva2013-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-790X2013000200388Revista Brasileira de Epidemiologia v.16 n.2 2013reponame:Revista brasileira de epidemiologia (Online)instname:Associação Brasileira de Saúde Coletiva (ABRASCO)instacron:ABRASCO10.1590/S1415-790X2013000200014info:eu-repo/semantics/openAccessLuft,Vivian C.Pereira,MarkPankow,James S.Ballantyne,ChristieCouper,DavidHeiss,GerardoDuncan,Bruce B.eng2015-11-24T00:00:00Zoai:scielo:S1415-790X2013000200388Revistahttp://www.scielo.br/rbepidhttps://old.scielo.br/oai/scielo-oai.php||revbrepi@usp.br1980-54971415-790Xopendoar:2015-11-24T00:00Revista brasileira de epidemiologia (Online) - Associação Brasileira de Saúde Coletiva (ABRASCO)false |
dc.title.none.fl_str_mv |
Retinol binding protein 4 and incident diabetes – the Atherosclerosis Risk in Communities Study (ARIC Study) |
title |
Retinol binding protein 4 and incident diabetes – the Atherosclerosis Risk in Communities Study (ARIC Study) |
spellingShingle |
Retinol binding protein 4 and incident diabetes – the Atherosclerosis Risk in Communities Study (ARIC Study) Luft,Vivian C. Diabetes Retinol-Binding Proteins RBP4 protein, human Epidemiologic Studies |
title_short |
Retinol binding protein 4 and incident diabetes – the Atherosclerosis Risk in Communities Study (ARIC Study) |
title_full |
Retinol binding protein 4 and incident diabetes – the Atherosclerosis Risk in Communities Study (ARIC Study) |
title_fullStr |
Retinol binding protein 4 and incident diabetes – the Atherosclerosis Risk in Communities Study (ARIC Study) |
title_full_unstemmed |
Retinol binding protein 4 and incident diabetes – the Atherosclerosis Risk in Communities Study (ARIC Study) |
title_sort |
Retinol binding protein 4 and incident diabetes – the Atherosclerosis Risk in Communities Study (ARIC Study) |
author |
Luft,Vivian C. |
author_facet |
Luft,Vivian C. Pereira,Mark Pankow,James S. Ballantyne,Christie Couper,David Heiss,Gerardo Duncan,Bruce B. |
author_role |
author |
author2 |
Pereira,Mark Pankow,James S. Ballantyne,Christie Couper,David Heiss,Gerardo Duncan,Bruce B. |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Luft,Vivian C. Pereira,Mark Pankow,James S. Ballantyne,Christie Couper,David Heiss,Gerardo Duncan,Bruce B. |
dc.subject.por.fl_str_mv |
Diabetes Retinol-Binding Proteins RBP4 protein, human Epidemiologic Studies |
topic |
Diabetes Retinol-Binding Proteins RBP4 protein, human Epidemiologic Studies |
description |
Background: Retinol binding protein 4 (RBP4) has been described as a link between impaired glucose uptake in adipocytes and systemic insulin sensitivity. Objective: To determine whether RBP4 fasting levels predict the development of type 2 diabetes. Methods: Using a case-cohort design, we followed 543 middle-aged individuals who developed diabetes and 537 who did not over ~9 years within the population-based Atherosclerosis Risk in Communities Study. Weighted Cox proportional hazards analyses permitted statistical inference of the RBP4 – incident diabetes associations to the entire cohort. Results: Women in the highest tertile of RBP4 presented greater risk of developing diabetes (HR = 1.74; 95%CI 1.03 – 2.94) in analyses adjusted for age, ethnicity, study center, parental history of diabetes, hypertension, glomerular filtration rate, body mass index, waist-hip ratio, nonesterified fatty acids, adiponectin, leptin, triglycerides and HDL-C. When additionally adjusted for fasting insulin, this association’s significance became borderline (HR = 1.68; 95%CI 1.00 – 2.82). No association between RBP4 levels and incident diabetes was found in men. Conclusion: These findings suggest that RBP4 levels may be directly involved in the pathogenesis of type 2 diabetes in women. |
publishDate |
2013 |
dc.date.none.fl_str_mv |
2013-06-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-790X2013000200388 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-790X2013000200388 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S1415-790X2013000200014 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Associação Brasileira de Saúde Coletiva |
publisher.none.fl_str_mv |
Associação Brasileira de Saúde Coletiva |
dc.source.none.fl_str_mv |
Revista Brasileira de Epidemiologia v.16 n.2 2013 reponame:Revista brasileira de epidemiologia (Online) instname:Associação Brasileira de Saúde Coletiva (ABRASCO) instacron:ABRASCO |
instname_str |
Associação Brasileira de Saúde Coletiva (ABRASCO) |
instacron_str |
ABRASCO |
institution |
ABRASCO |
reponame_str |
Revista brasileira de epidemiologia (Online) |
collection |
Revista brasileira de epidemiologia (Online) |
repository.name.fl_str_mv |
Revista brasileira de epidemiologia (Online) - Associação Brasileira de Saúde Coletiva (ABRASCO) |
repository.mail.fl_str_mv |
||revbrepi@usp.br |
_version_ |
1754212953325830144 |