Initial antiretroviral therapy in a 20-year observational cohort of patients followed at a reference center in the City of São Paulo, Brazil

• Autor(a) principal: Ruiz,Emily A. C.
• Data de Publicação: 2011
• Outros Autores: Ramalho,Marta, Tancredi,Mariza V., Moatti,Jean P., Monteiro,Ana L. C., Fonsi,Mylva, Chauveau,Julien
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Revista brasileira de epidemiologia (Online)
• Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-790X2011000100008
• topic: Antiretroviral treatment; Treatment; HIV; Aids; Epidemiology; ART

INTRODUCTION: Production and free universal access to ART for patients with HIV/Aids were responsible for a major fall in morbidity-mortality in Brazil. OBJECTIVE: To describe antiretroviral treatment at the São Paulo STD/Aids Training and Reference Center. METHODS: Cross-sectional analysis of the characteristics of the first treatment with antiretroviral drugs of a retrospective cohort of patients 13 years and over, enrolled at the Reference Center, 1985-2005, described by frequency tables and graphs. RESULTS: 4,191 patients were described. The most frequent initiation period was 1999-2003; 82.7% of patients were treatment naïve. Monotherapy prevailed until 1995, the peak of double therapy was 1996-98, and 1999-2005 was characterized by triple therapy. Regarding triple therapy, regimens with protease inhibitors accounted for 1,462 (34.9%) of all first prescriptions. The combination AZT, 3TC and EFV was the most frequently prescribed regimen (47.4%) in 2005. CONCLUSIONS: This descriptive study may enable more in depth analyses on the factors involved in the treatment patients with HIV/AIDS.