A review of pesticide exposure and cancer incidence in the agricultural health study cohort
Autor(a) principal: | |
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Data de Publicação: | 2012 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Ciência & Saúde Coletiva (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-81232012000100028 |
Resumo: | We reviewed epidemiologic evidence related to occupational pesticide exposures and cancer incidence in the Agricultural Health Study (AHS) cohort. Studies were identified from the AHS publication list available on a Medline/PubMed database search in March 2009. Findings related to lifetime-days and/or intensity-weighted lifetime-days of pesticide use are the primary focus of this review, because these measures allow for the evaluation of potential exposureresponse relationships. Most of the 32 pesticides examined were not strongly associated with cancer incidence in pesticide applicators. Increased rate ratios and positive exposureresponse patterns were reported for 12 pesticides currently registered in Canada and/or the United States. Exposure misclassification is also a concern in the AHS and may limit the analysis of exposureresponse patterns. Epidemiologic evidence outside the AHS remains limited with respect to most of the observed associations, but animal toxicity data support the biological plausibility of relationships observed six pesticides. Continued follow-up is needed to clarify associations reported to date. In particular, further evaluation of registered pesticides is warranted. |
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A review of pesticide exposure and cancer incidence in the agricultural health study cohortAgricultural health studyCancerPesticidesReviewWe reviewed epidemiologic evidence related to occupational pesticide exposures and cancer incidence in the Agricultural Health Study (AHS) cohort. Studies were identified from the AHS publication list available on a Medline/PubMed database search in March 2009. Findings related to lifetime-days and/or intensity-weighted lifetime-days of pesticide use are the primary focus of this review, because these measures allow for the evaluation of potential exposureresponse relationships. Most of the 32 pesticides examined were not strongly associated with cancer incidence in pesticide applicators. Increased rate ratios and positive exposureresponse patterns were reported for 12 pesticides currently registered in Canada and/or the United States. Exposure misclassification is also a concern in the AHS and may limit the analysis of exposureresponse patterns. Epidemiologic evidence outside the AHS remains limited with respect to most of the observed associations, but animal toxicity data support the biological plausibility of relationships observed six pesticides. Continued follow-up is needed to clarify associations reported to date. In particular, further evaluation of registered pesticides is warranted.ABRASCO - Associação Brasileira de Saúde Coletiva2012-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-81232012000100028Ciência & Saúde Coletiva v.17 n.1 2012reponame:Ciência & Saúde Coletiva (Online)instname:Associação Brasileira de Saúde Coletiva (ABRASCO)instacron:ABRASCO10.1590/S1413-81232012000100028info:eu-repo/semantics/openAccessWeichenthal,ScottMoase,ConnieChan,Petereng2012-01-24T00:00:00Zoai:scielo:S1413-81232012000100028Revistahttp://www.cienciaesaudecoletiva.com.brhttps://old.scielo.br/oai/scielo-oai.php||cienciasaudecoletiva@fiocruz.br1678-45611413-8123opendoar:2012-01-24T00:00Ciência & Saúde Coletiva (Online) - Associação Brasileira de Saúde Coletiva (ABRASCO)false |
dc.title.none.fl_str_mv |
A review of pesticide exposure and cancer incidence in the agricultural health study cohort |
title |
A review of pesticide exposure and cancer incidence in the agricultural health study cohort |
spellingShingle |
A review of pesticide exposure and cancer incidence in the agricultural health study cohort Weichenthal,Scott Agricultural health study Cancer Pesticides Review |
title_short |
A review of pesticide exposure and cancer incidence in the agricultural health study cohort |
title_full |
A review of pesticide exposure and cancer incidence in the agricultural health study cohort |
title_fullStr |
A review of pesticide exposure and cancer incidence in the agricultural health study cohort |
title_full_unstemmed |
A review of pesticide exposure and cancer incidence in the agricultural health study cohort |
title_sort |
A review of pesticide exposure and cancer incidence in the agricultural health study cohort |
author |
Weichenthal,Scott |
author_facet |
Weichenthal,Scott Moase,Connie Chan,Peter |
author_role |
author |
author2 |
Moase,Connie Chan,Peter |
author2_role |
author author |
dc.contributor.author.fl_str_mv |
Weichenthal,Scott Moase,Connie Chan,Peter |
dc.subject.por.fl_str_mv |
Agricultural health study Cancer Pesticides Review |
topic |
Agricultural health study Cancer Pesticides Review |
description |
We reviewed epidemiologic evidence related to occupational pesticide exposures and cancer incidence in the Agricultural Health Study (AHS) cohort. Studies were identified from the AHS publication list available on a Medline/PubMed database search in March 2009. Findings related to lifetime-days and/or intensity-weighted lifetime-days of pesticide use are the primary focus of this review, because these measures allow for the evaluation of potential exposureresponse relationships. Most of the 32 pesticides examined were not strongly associated with cancer incidence in pesticide applicators. Increased rate ratios and positive exposureresponse patterns were reported for 12 pesticides currently registered in Canada and/or the United States. Exposure misclassification is also a concern in the AHS and may limit the analysis of exposureresponse patterns. Epidemiologic evidence outside the AHS remains limited with respect to most of the observed associations, but animal toxicity data support the biological plausibility of relationships observed six pesticides. Continued follow-up is needed to clarify associations reported to date. In particular, further evaluation of registered pesticides is warranted. |
publishDate |
2012 |
dc.date.none.fl_str_mv |
2012-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-81232012000100028 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-81232012000100028 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S1413-81232012000100028 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
ABRASCO - Associação Brasileira de Saúde Coletiva |
publisher.none.fl_str_mv |
ABRASCO - Associação Brasileira de Saúde Coletiva |
dc.source.none.fl_str_mv |
Ciência & Saúde Coletiva v.17 n.1 2012 reponame:Ciência & Saúde Coletiva (Online) instname:Associação Brasileira de Saúde Coletiva (ABRASCO) instacron:ABRASCO |
instname_str |
Associação Brasileira de Saúde Coletiva (ABRASCO) |
instacron_str |
ABRASCO |
institution |
ABRASCO |
reponame_str |
Ciência & Saúde Coletiva (Online) |
collection |
Ciência & Saúde Coletiva (Online) |
repository.name.fl_str_mv |
Ciência & Saúde Coletiva (Online) - Associação Brasileira de Saúde Coletiva (ABRASCO) |
repository.mail.fl_str_mv |
||cienciasaudecoletiva@fiocruz.br |
_version_ |
1754213032224882688 |