Prevalence and multiplicity of HPV in HIV women in Minas Gerais, Brazil

• Autor(a) principal: Corrêa,Christine Miranda
• Data de Publicação: 2011
• Outros Autores: Teixeira,Nara Chartuni Pereira, Araújo,Angela Cristina Labanca de, Carvalho,Nara de Oliveira, Castillo,Dora Mendez Del, Campos,Rachel Rezende, Oliveira,Isaura Vargas, Alves,Antonio Rafael, França,Ana Flávia de Moura, Melo,Victor Hugo
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Revista da Associação Médica Brasileira (Online)
• Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-42302011000400017
• topic: DNA probes, HPV; HIV; polymerase chain reaction; cervix uteri; papillomavirus infections, prevalence

OBJECTIVE: To detect the frequency and subtypes of HPV in the uterine cervix of HIV-infected women. METHODS: Sample consisted of 288 HIV-infected women, recruited from the public health system of five cities of Minas Gerais, Brazil. Women were seen from August 2003 to August 2008. Cervical samples were collected for cytological analysis and for HPV DNA detection, using polymerase chain reaction (PCR). HPV DNA was classified according to its oncogenic potential in low risk (types 6, 11) and high risk (types 16, 18, 31, 33, 35). Colposcopy was performed, followed by cervical biopsy when necessary. Categorical variables were compared using the Chi-squared test, with a significance level established at the 5% level. RESULTS: HPV prevalence was 78.8%. Most frequent genotypes were HPV-6 (63.9%) and HPV-16 (48.5%). High-risk HPV were observed in 70.5% of the women; low-risk in 71.4%; both high and low-risk HPV were detected in 55.1% of the patients. Multiple HPV genotypes were detected in 64.8% of the patients; two genotypes in 23.8%, and three in 18.9%. CONCLUSION: HPV prevalence was high among HIV-infected women. Multiple HPV genotypes were common in samples from the uterine cervix of HIV-infected women