Renal changes and acute kidney injury in covid-19: a systematic review
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Revista da Associação Médica Brasileira (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-42302020001400112 |
Resumo: | SUMMARY OBJECTIVE We aimed to present a review of renal changes in patients with COVID-19. METHODS We performed a systematic review of the literature to identify original articles regarding clinical, laboratory, and anatomopathological kidney changes in patients infected with SARS-CoV-2 published until May 7, 2020. The search was carried out across PubMed, Scopus, and Embase using the keywords “COVID-19”, “coronavirus”, “SARS-CoV-2”, “kidney injury” and “kidney disease”. Fifteen studies presented clinical and laboratory renal changes in patients with COVID-19, and three addressed anatomopathological changes. DISCUSSION Acute kidney injury (AKI) was a relevant finding in patients with COVID-19. There were also significant changes in laboratory tests that indicated kidney injury, such as increased serum creatinine and blood urea nitrogen (BUN), proteinuria, and hematuria. The presence of laboratory abnormalities and AKI were significant in severely ill patients. There was a considerable prevalence of AKI among groups of patients who died of COVID-19. Histopathological analysis of the kidney tissue of patients infected with SARS-CoV-2 suggested that the virus may directly affect the kidneys. CONCLUSION Although COVID-19 affects mainly the lungs, it can also impact the kidneys. Increased serum creatinine and BUN, hematuria, proteinuria, and AKI were frequent findings in patients with severe COVID-19 and were related to an increased mortality rate. Further studies focusing on renal changes and their implications for the clinical condition of patients infected with the novel coronavirus are needed. |
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Renal changes and acute kidney injury in covid-19: a systematic reviewCoronavirusCoronavirus InfectionsBetacoronavirusAcute Kidney InjuryRenal InsufficiencySUMMARY OBJECTIVE We aimed to present a review of renal changes in patients with COVID-19. METHODS We performed a systematic review of the literature to identify original articles regarding clinical, laboratory, and anatomopathological kidney changes in patients infected with SARS-CoV-2 published until May 7, 2020. The search was carried out across PubMed, Scopus, and Embase using the keywords “COVID-19”, “coronavirus”, “SARS-CoV-2”, “kidney injury” and “kidney disease”. Fifteen studies presented clinical and laboratory renal changes in patients with COVID-19, and three addressed anatomopathological changes. DISCUSSION Acute kidney injury (AKI) was a relevant finding in patients with COVID-19. There were also significant changes in laboratory tests that indicated kidney injury, such as increased serum creatinine and blood urea nitrogen (BUN), proteinuria, and hematuria. The presence of laboratory abnormalities and AKI were significant in severely ill patients. There was a considerable prevalence of AKI among groups of patients who died of COVID-19. Histopathological analysis of the kidney tissue of patients infected with SARS-CoV-2 suggested that the virus may directly affect the kidneys. CONCLUSION Although COVID-19 affects mainly the lungs, it can also impact the kidneys. Increased serum creatinine and BUN, hematuria, proteinuria, and AKI were frequent findings in patients with severe COVID-19 and were related to an increased mortality rate. Further studies focusing on renal changes and their implications for the clinical condition of patients infected with the novel coronavirus are needed.Associação Médica Brasileira2020-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-42302020001400112Revista da Associação Médica Brasileira v.66 suppl.2 2020reponame:Revista da Associação Médica Brasileira (Online)instname:Associação Médica Brasileira (AMB)instacron:AMB10.1590/1806-9282.66.s2.112info:eu-repo/semantics/openAccessNogueira,Samuel Átila RodriguesOliveira,Samuel Ciríaco Silva deCarvalho,Ana Flávia Moreira deNeves,Julia Moreira CavalcanteSilva,Leila Silveira Vieira daSilva Junior,Geraldo Bezerra daNobre,Maria Elizabeth Pereiraeng2020-11-04T00:00:00Zoai:scielo:S0104-42302020001400112Revistahttps://ramb.amb.org.br/ultimas-edicoes/#https://old.scielo.br/oai/scielo-oai.php||ramb@amb.org.br1806-92820104-4230opendoar:2020-11-04T00:00Revista da Associação Médica Brasileira (Online) - Associação Médica Brasileira (AMB)false |
dc.title.none.fl_str_mv |
Renal changes and acute kidney injury in covid-19: a systematic review |
title |
Renal changes and acute kidney injury in covid-19: a systematic review |
spellingShingle |
Renal changes and acute kidney injury in covid-19: a systematic review Nogueira,Samuel Átila Rodrigues Coronavirus Coronavirus Infections Betacoronavirus Acute Kidney Injury Renal Insufficiency |
title_short |
Renal changes and acute kidney injury in covid-19: a systematic review |
title_full |
Renal changes and acute kidney injury in covid-19: a systematic review |
title_fullStr |
Renal changes and acute kidney injury in covid-19: a systematic review |
title_full_unstemmed |
Renal changes and acute kidney injury in covid-19: a systematic review |
title_sort |
Renal changes and acute kidney injury in covid-19: a systematic review |
author |
Nogueira,Samuel Átila Rodrigues |
author_facet |
Nogueira,Samuel Átila Rodrigues Oliveira,Samuel Ciríaco Silva de Carvalho,Ana Flávia Moreira de Neves,Julia Moreira Cavalcante Silva,Leila Silveira Vieira da Silva Junior,Geraldo Bezerra da Nobre,Maria Elizabeth Pereira |
author_role |
author |
author2 |
Oliveira,Samuel Ciríaco Silva de Carvalho,Ana Flávia Moreira de Neves,Julia Moreira Cavalcante Silva,Leila Silveira Vieira da Silva Junior,Geraldo Bezerra da Nobre,Maria Elizabeth Pereira |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Nogueira,Samuel Átila Rodrigues Oliveira,Samuel Ciríaco Silva de Carvalho,Ana Flávia Moreira de Neves,Julia Moreira Cavalcante Silva,Leila Silveira Vieira da Silva Junior,Geraldo Bezerra da Nobre,Maria Elizabeth Pereira |
dc.subject.por.fl_str_mv |
Coronavirus Coronavirus Infections Betacoronavirus Acute Kidney Injury Renal Insufficiency |
topic |
Coronavirus Coronavirus Infections Betacoronavirus Acute Kidney Injury Renal Insufficiency |
description |
SUMMARY OBJECTIVE We aimed to present a review of renal changes in patients with COVID-19. METHODS We performed a systematic review of the literature to identify original articles regarding clinical, laboratory, and anatomopathological kidney changes in patients infected with SARS-CoV-2 published until May 7, 2020. The search was carried out across PubMed, Scopus, and Embase using the keywords “COVID-19”, “coronavirus”, “SARS-CoV-2”, “kidney injury” and “kidney disease”. Fifteen studies presented clinical and laboratory renal changes in patients with COVID-19, and three addressed anatomopathological changes. DISCUSSION Acute kidney injury (AKI) was a relevant finding in patients with COVID-19. There were also significant changes in laboratory tests that indicated kidney injury, such as increased serum creatinine and blood urea nitrogen (BUN), proteinuria, and hematuria. The presence of laboratory abnormalities and AKI were significant in severely ill patients. There was a considerable prevalence of AKI among groups of patients who died of COVID-19. Histopathological analysis of the kidney tissue of patients infected with SARS-CoV-2 suggested that the virus may directly affect the kidneys. CONCLUSION Although COVID-19 affects mainly the lungs, it can also impact the kidneys. Increased serum creatinine and BUN, hematuria, proteinuria, and AKI were frequent findings in patients with severe COVID-19 and were related to an increased mortality rate. Further studies focusing on renal changes and their implications for the clinical condition of patients infected with the novel coronavirus are needed. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-42302020001400112 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-42302020001400112 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/1806-9282.66.s2.112 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Associação Médica Brasileira |
publisher.none.fl_str_mv |
Associação Médica Brasileira |
dc.source.none.fl_str_mv |
Revista da Associação Médica Brasileira v.66 suppl.2 2020 reponame:Revista da Associação Médica Brasileira (Online) instname:Associação Médica Brasileira (AMB) instacron:AMB |
instname_str |
Associação Médica Brasileira (AMB) |
instacron_str |
AMB |
institution |
AMB |
reponame_str |
Revista da Associação Médica Brasileira (Online) |
collection |
Revista da Associação Médica Brasileira (Online) |
repository.name.fl_str_mv |
Revista da Associação Médica Brasileira (Online) - Associação Médica Brasileira (AMB) |
repository.mail.fl_str_mv |
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