Interferon-induced depression in patients with hepatitis C: an epidemiologic study

Detalhes bibliográficos
Autor(a) principal: Medeiros,Lucas Pereira Jorge de
Data de Publicação: 2014
Outros Autores: Kayo,Monica, Medeiros,Renata Barboza Vianna, Lima,Mario Barreto Correa, Mello,Carlos Eduardo Brandão Mello
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Revista da Associação Médica Brasileira (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-42302014000100035
Resumo: Objective To assess the incidence rate and severity of depressive symptoms in different time points (12, 24 and 48 weeks) in Brazilian patients with HCV treated with PEG IFN plus ribavirin. Methods We conducted an observational prospective study using the Beck Depression Inventory (BDI) and the Center for Epidemiologic Studies Depression Scale (CES-D). Results Fifty patients were included. The assessments with either scale showed the highest score of depressive symptoms in the 24th week of treatment; the mean BDI score before treatment was 6.5 ± 5.3 and the mean CES-D was 10.9 ± 7.8. After 24 weeks, the mean BDI was 16.1 ± 10.2 and mean CES-D was 18.6 ± 13.0; 46% were diagnosed with depression according to combined BDI and CES-D scores. The somatic/psychomotor subscales were highly correlated with overall scale scores . Subjects with history of substance and alcohol abuse had higher risk for IFN-induced depression. Conclusion Treatment with PEG IFN was associated with a high incidence rate of depressive symptoms in this sample of Brazilian patients, as measured by CES-D and BDI. Alcohol and substance abuse increase the risk of PEG IFN-induced depression.
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spelling Interferon-induced depression in patients with hepatitis C: an epidemiologic studyHCVpegylated interferon alpha-2binterferon alphadepressionhepatitis Objective To assess the incidence rate and severity of depressive symptoms in different time points (12, 24 and 48 weeks) in Brazilian patients with HCV treated with PEG IFN plus ribavirin. Methods We conducted an observational prospective study using the Beck Depression Inventory (BDI) and the Center for Epidemiologic Studies Depression Scale (CES-D). Results Fifty patients were included. The assessments with either scale showed the highest score of depressive symptoms in the 24th week of treatment; the mean BDI score before treatment was 6.5 ± 5.3 and the mean CES-D was 10.9 ± 7.8. After 24 weeks, the mean BDI was 16.1 ± 10.2 and mean CES-D was 18.6 ± 13.0; 46% were diagnosed with depression according to combined BDI and CES-D scores. The somatic/psychomotor subscales were highly correlated with overall scale scores . Subjects with history of substance and alcohol abuse had higher risk for IFN-induced depression. Conclusion Treatment with PEG IFN was associated with a high incidence rate of depressive symptoms in this sample of Brazilian patients, as measured by CES-D and BDI. Alcohol and substance abuse increase the risk of PEG IFN-induced depression. Associação Médica Brasileira2014-02-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-42302014000100035Revista da Associação Médica Brasileira v.60 n.1 2014reponame:Revista da Associação Médica Brasileira (Online)instname:Associação Médica Brasileira (AMB)instacron:AMB10.1590/1806-9282.60.01.009info:eu-repo/semantics/openAccessMedeiros,Lucas Pereira Jorge deKayo,MonicaMedeiros,Renata Barboza ViannaLima,Mario Barreto CorreaMello,Carlos Eduardo Brandão Melloeng2015-01-09T00:00:00Zoai:scielo:S0104-42302014000100035Revistahttps://ramb.amb.org.br/ultimas-edicoes/#https://old.scielo.br/oai/scielo-oai.php||ramb@amb.org.br1806-92820104-4230opendoar:2015-01-09T00:00Revista da Associação Médica Brasileira (Online) - Associação Médica Brasileira (AMB)false
dc.title.none.fl_str_mv Interferon-induced depression in patients with hepatitis C: an epidemiologic study
title Interferon-induced depression in patients with hepatitis C: an epidemiologic study
spellingShingle Interferon-induced depression in patients with hepatitis C: an epidemiologic study
Medeiros,Lucas Pereira Jorge de
HCV
pegylated interferon alpha-2b
interferon alpha
depression
hepatitis
title_short Interferon-induced depression in patients with hepatitis C: an epidemiologic study
title_full Interferon-induced depression in patients with hepatitis C: an epidemiologic study
title_fullStr Interferon-induced depression in patients with hepatitis C: an epidemiologic study
title_full_unstemmed Interferon-induced depression in patients with hepatitis C: an epidemiologic study
title_sort Interferon-induced depression in patients with hepatitis C: an epidemiologic study
author Medeiros,Lucas Pereira Jorge de
author_facet Medeiros,Lucas Pereira Jorge de
Kayo,Monica
Medeiros,Renata Barboza Vianna
Lima,Mario Barreto Correa
Mello,Carlos Eduardo Brandão Mello
author_role author
author2 Kayo,Monica
Medeiros,Renata Barboza Vianna
Lima,Mario Barreto Correa
Mello,Carlos Eduardo Brandão Mello
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Medeiros,Lucas Pereira Jorge de
Kayo,Monica
Medeiros,Renata Barboza Vianna
Lima,Mario Barreto Correa
Mello,Carlos Eduardo Brandão Mello
dc.subject.por.fl_str_mv HCV
pegylated interferon alpha-2b
interferon alpha
depression
hepatitis
topic HCV
pegylated interferon alpha-2b
interferon alpha
depression
hepatitis
description Objective To assess the incidence rate and severity of depressive symptoms in different time points (12, 24 and 48 weeks) in Brazilian patients with HCV treated with PEG IFN plus ribavirin. Methods We conducted an observational prospective study using the Beck Depression Inventory (BDI) and the Center for Epidemiologic Studies Depression Scale (CES-D). Results Fifty patients were included. The assessments with either scale showed the highest score of depressive symptoms in the 24th week of treatment; the mean BDI score before treatment was 6.5 ± 5.3 and the mean CES-D was 10.9 ± 7.8. After 24 weeks, the mean BDI was 16.1 ± 10.2 and mean CES-D was 18.6 ± 13.0; 46% were diagnosed with depression according to combined BDI and CES-D scores. The somatic/psychomotor subscales were highly correlated with overall scale scores . Subjects with history of substance and alcohol abuse had higher risk for IFN-induced depression. Conclusion Treatment with PEG IFN was associated with a high incidence rate of depressive symptoms in this sample of Brazilian patients, as measured by CES-D and BDI. Alcohol and substance abuse increase the risk of PEG IFN-induced depression.
publishDate 2014
dc.date.none.fl_str_mv 2014-02-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
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dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-42302014000100035
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-42302014000100035
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/1806-9282.60.01.009
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Associação Médica Brasileira
publisher.none.fl_str_mv Associação Médica Brasileira
dc.source.none.fl_str_mv Revista da Associação Médica Brasileira v.60 n.1 2014
reponame:Revista da Associação Médica Brasileira (Online)
instname:Associação Médica Brasileira (AMB)
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reponame_str Revista da Associação Médica Brasileira (Online)
collection Revista da Associação Médica Brasileira (Online)
repository.name.fl_str_mv Revista da Associação Médica Brasileira (Online) - Associação Médica Brasileira (AMB)
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