A successful case of anti-NMDAR encephalitis without tumor treated with a prolonged regimen of plasmapheresis

Detalhes bibliográficos
Autor(a) principal: Simabukuro,Mateus Mistieri
Data de Publicação: 2014
Outros Autores: Watanabe,Rafael Gustavo Sato, Pinto,Lécio Figueira, Guariglia,Carla, Gonçalves,Daniella Costa de Menezes e, Anghinah,Renato
Tipo de documento: Relatório
Idioma: eng
Título da fonte: Dementia & Neuropsychologia
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1980-57642014000100087
Resumo: ABSTRACT Anti-NMDA receptor encephalitis is a severe but treatable autoimmune disease of the CNS. However, the use of immunotherapy and long-term outcomes have yet to be defined for this disease. We describe a case of an 18-year-old male diagnosed with anti-NMDAR encephalitis not associated with tumor, which did not respond to initial treatment with immunoglobulin, followed by corticosteroids, cyclophosphamide and evolved with significant clinical improvement after a prolonged course of plasmapheresis. Although it is not possible to affirm the good outcome was due solely to the prolonged plasmapheresis regimen, recently published data shows that improvement may take weeks or months to occur. This case discloses another therapeutic possibility for patients with refractory disease who fail to respond to recommended first-line and second-line therapy.
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spelling A successful case of anti-NMDAR encephalitis without tumor treated with a prolonged regimen of plasmapheresisautoimmune diseaseencephalitisanti-NMDA receptorplasmapheresispsychiatric symptomsABSTRACT Anti-NMDA receptor encephalitis is a severe but treatable autoimmune disease of the CNS. However, the use of immunotherapy and long-term outcomes have yet to be defined for this disease. We describe a case of an 18-year-old male diagnosed with anti-NMDAR encephalitis not associated with tumor, which did not respond to initial treatment with immunoglobulin, followed by corticosteroids, cyclophosphamide and evolved with significant clinical improvement after a prolonged course of plasmapheresis. Although it is not possible to affirm the good outcome was due solely to the prolonged plasmapheresis regimen, recently published data shows that improvement may take weeks or months to occur. This case discloses another therapeutic possibility for patients with refractory disease who fail to respond to recommended first-line and second-line therapy.Academia Brasileira de Neurologia, Departamento de Neurologia Cognitiva e Envelhecimento2014-03-01info:eu-repo/semantics/reportinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1980-57642014000100087Dementia & Neuropsychologia v.8 n.1 2014reponame:Dementia & Neuropsychologiainstname:Associação de Neurologia Cognitiva e do Comportamento (ANCC)instacron:ANCC10.1590/S1980-57642014DN81000014info:eu-repo/semantics/openAccessSimabukuro,Mateus MistieriWatanabe,Rafael Gustavo SatoPinto,Lécio FigueiraGuariglia,CarlaGonçalves,Daniella Costa de Menezes eAnghinah,Renatoeng2016-01-06T00:00:00Zoai:scielo:S1980-57642014000100087Revistahttp://www.demneuropsy.com.br/ONGhttps://old.scielo.br/oai/scielo-oai.php||demneuropsy@uol.com.br1980-57641980-5764opendoar:2016-01-06T00:00Dementia & Neuropsychologia - Associação de Neurologia Cognitiva e do Comportamento (ANCC)false
dc.title.none.fl_str_mv A successful case of anti-NMDAR encephalitis without tumor treated with a prolonged regimen of plasmapheresis
title A successful case of anti-NMDAR encephalitis without tumor treated with a prolonged regimen of plasmapheresis
spellingShingle A successful case of anti-NMDAR encephalitis without tumor treated with a prolonged regimen of plasmapheresis
Simabukuro,Mateus Mistieri
autoimmune disease
encephalitis
anti-NMDA receptor
plasmapheresis
psychiatric symptoms
title_short A successful case of anti-NMDAR encephalitis without tumor treated with a prolonged regimen of plasmapheresis
title_full A successful case of anti-NMDAR encephalitis without tumor treated with a prolonged regimen of plasmapheresis
title_fullStr A successful case of anti-NMDAR encephalitis without tumor treated with a prolonged regimen of plasmapheresis
title_full_unstemmed A successful case of anti-NMDAR encephalitis without tumor treated with a prolonged regimen of plasmapheresis
title_sort A successful case of anti-NMDAR encephalitis without tumor treated with a prolonged regimen of plasmapheresis
author Simabukuro,Mateus Mistieri
author_facet Simabukuro,Mateus Mistieri
Watanabe,Rafael Gustavo Sato
Pinto,Lécio Figueira
Guariglia,Carla
Gonçalves,Daniella Costa de Menezes e
Anghinah,Renato
author_role author
author2 Watanabe,Rafael Gustavo Sato
Pinto,Lécio Figueira
Guariglia,Carla
Gonçalves,Daniella Costa de Menezes e
Anghinah,Renato
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Simabukuro,Mateus Mistieri
Watanabe,Rafael Gustavo Sato
Pinto,Lécio Figueira
Guariglia,Carla
Gonçalves,Daniella Costa de Menezes e
Anghinah,Renato
dc.subject.por.fl_str_mv autoimmune disease
encephalitis
anti-NMDA receptor
plasmapheresis
psychiatric symptoms
topic autoimmune disease
encephalitis
anti-NMDA receptor
plasmapheresis
psychiatric symptoms
description ABSTRACT Anti-NMDA receptor encephalitis is a severe but treatable autoimmune disease of the CNS. However, the use of immunotherapy and long-term outcomes have yet to be defined for this disease. We describe a case of an 18-year-old male diagnosed with anti-NMDAR encephalitis not associated with tumor, which did not respond to initial treatment with immunoglobulin, followed by corticosteroids, cyclophosphamide and evolved with significant clinical improvement after a prolonged course of plasmapheresis. Although it is not possible to affirm the good outcome was due solely to the prolonged plasmapheresis regimen, recently published data shows that improvement may take weeks or months to occur. This case discloses another therapeutic possibility for patients with refractory disease who fail to respond to recommended first-line and second-line therapy.
publishDate 2014
dc.date.none.fl_str_mv 2014-03-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/report
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format report
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1980-57642014000100087
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1980-57642014000100087
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S1980-57642014DN81000014
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Academia Brasileira de Neurologia, Departamento de Neurologia Cognitiva e Envelhecimento
publisher.none.fl_str_mv Academia Brasileira de Neurologia, Departamento de Neurologia Cognitiva e Envelhecimento
dc.source.none.fl_str_mv Dementia & Neuropsychologia v.8 n.1 2014
reponame:Dementia & Neuropsychologia
instname:Associação de Neurologia Cognitiva e do Comportamento (ANCC)
instacron:ANCC
instname_str Associação de Neurologia Cognitiva e do Comportamento (ANCC)
instacron_str ANCC
institution ANCC
reponame_str Dementia & Neuropsychologia
collection Dementia & Neuropsychologia
repository.name.fl_str_mv Dementia & Neuropsychologia - Associação de Neurologia Cognitiva e do Comportamento (ANCC)
repository.mail.fl_str_mv ||demneuropsy@uol.com.br
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